MicroRNA Profiling in the Medial and Lateral Habenula of Rats Exposed to the Learned Helplessness Paradigm: Candidate Biomarkers for Susceptibility and Resilience to Inescapable Shock.

Autor: Katrine Svenningsen, Morten T Venø, Kim Henningsen, Anne S Mallien, Line Jensen, Trine Christensen, Jørgen Kjems, Barbara Vollmayr, Ove Wiborg

Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0160318 (2016)

Depression is a highly heterogeneous disorder presumably caused by a combination of several factors ultimately causing the pathological condition. The genetic liability model of depression is likely to be of polygenic heterogeneity. miRNAs can regula

Externí odkaz: https://doaj.org/article/abffb60e380a42fb9d06be5452013edf

The continued need for animals to advance brain research

Autor: Paul J. Lucassen, Kate Jeffrey, Antonis Asiminas, Heidi M. B. Lesscher, Jos Prickaerts, Gertjan van Dijk, Amanda J. Kiliaan, Daniela Jezova, Carlos P. Fitzsimons, Klaus-Peter Lesch, S. Mechiel Korte, Ulrich L. M. Eisel, Roger A.H. Adan, Tamas Kozicz, Liset Menendez de la Prida, Joanes Grandjean, Marloes J. A. G. Henckens, Corette J. Wierenga, Vladyslav V. Vyazovskiy, Cyriel M. A. Pennartz, Marten P. Smidt, Ype Elgersma, Anne S. Mallien, Sharon M. Kolk, Liya Ma, Kirk Leech, Ingo Willuhn, Jorge F. Mejias, Maximilian Wiesmann, Frank J. Meye, Louk J. M. J. Vanderschuren, Marilise Escobar Burger, Sidarta Ribeiro, August B. Smit, Peter Meerlo, Robbert Havekes, Eddy A. van der Zee, Rixt van der Veen, Regien G. Schoemaker, Massimo Pasqualetti, Andries Kalsbeek, Martien J H Kas, Michael Bader, Joram D. Mul, Bernhard Englitz, Janine I. Rossato, Denovan P. Begg, Tomonori Takeuchi, Markus Wöhr, Antonio Fernández-Ruiz, Bella Williams, Nael Nadif Kasri, Aniko Korosi, Judith R. Homberg, Tom Beckers, Maarten Kamermans, Piotr Popik, Peter Gass, Umberto Olcese, Anna S. Mitchell, Christiane Herden, Jocelien D A Olivier, Monique Wolvekamp, Arjan Blokland, Azahara Oliva González, Natalia Alenina, Lisa Genzel, Wendy Jarrett, Ali-Akbar Salari, Roelof A. Hut, Anne-Marie van Dam, Anita Lüthi, Benno Roozendaal, Steven A. Kushner

Publikováno v: Neuron, 109(15), 2374-2379. Cell Press
Neuron, 109(15), 2374. Cell Press
Neuron, 109, 15, pp. 2374-2379
Neuron, 109, 2374-2379
Homberg, J R, Adan, R A H, Alenina, N, Asiminas, A, Bader, M, Beckers, T, Begg, D P, Blokland, A, Burger, M E, van Dijk, G, Eisel, U L M, Elgersma, Y, Englitz, B, Fernandez-Ruiz, A, Fitzsimons, C P, van Dam, A M, Gass, P, Grandjean, J, Havekes, R, Henckens, M J A G, Herden, C, Hut, R A, Jarrett, W, Jeffrey, K, Jezova, D, Kalsbeek, A, Kamermans, M, Kas, M J, Kasri, N N, Kiliaan, A J, Kolk, S M, Korosi, A, Korte, S M, Kozicz, T, Kushner, S A, Leech, K, Lesch, K P, Lesscher, H, Lucassen, P J, Luthi, A, Ma, L, Mallien, A S, Meerlo, P, Mejias, J F, Meye, F J, Mitchell, A S, Mul, J D, Olcese, U, González, A O, Olivier, J D A, Pasqualetti, M, Pennartz, C M A, Popik, P, Prickaerts, J, de la Prida, L M, Ribeiro, S, Roozendaal, B, Rossato, J I, Salari, A A, Schoemaker, R G, Smit, A B, Vanderschuren, L J M J, Takeuchi, T, van der Veen, R, Smidt, M P, Vyazovskiy, V V, Wiesmann, M, Wierenga, C J, Williams, B, Willuhn, I, Wöhr, M, Wolvekamp, M, van der Zee, E A & Genzel, L 2021, ' The continued need for animals to advance brain research ', Neuron, vol. 109, no. 15, pp. 2374-2379 . https://doi.org/10.1016/j.neuron.2021.07.015
Homberg, J R, Adan, R A H, Alenina, N, Asiminas, A, Bader, M, Beckers, T, Begg, D P, Blokland, A, Burger, M E, van Dijk, G, Eisel, U L M, Elgersma, Y, Englitz, B, Fernandez-Ruiz, A, Fitzsimons, C P, van Dam, A-M, Gass, P, Grandjean, J, Havekes, R, Henckens, M J A G, Herden, C, Hut, R A, Jarrett, W, Jeffrey, K, Jezova, D, Kalsbeek, A, Kamermans, M, Kas, M J, Kasri, N N, Kiliaan, A J, Kolk, S M, Korosi, A, Korte, S M, Kozicz, T, Kushner, S A, Leech, K, Lesch, K-P, Lesscher, H, Lucassen, P J, Luthi, A, Ma, L, Mallien, A S, Meerlo, P, Mejias, J F, Meye, F J, Mitchell, A S, Mul, J D, Olcese, U, González, A O, Olivier, J D A, Pasqualetti, M, Pennartz, C M A, Popik, P, Prickaerts, J, de la Prida, L M, Ribeiro, S, Roozendaal, B, Rossato, J I, Salari, A-A, Schoemaker, R G, Smit, A B, Vanderschuren, L J M J, Takeuchi, T, van der Veen, R, Smidt, M P, Vyazovskiy, V V, Wiesmann, M, Wierenga, C J, Williams, B, Willuhn, I, Wöhr, M, Wolvekamp, M, van der Zee, E A & Genzel, L 2021, ' The continued need for animals to advance brain research ', Neuron, vol. 109, no. 15, pp. 2374-2379 . https://doi.org/10.1016/j.neuron.2021.07.015
Neuron, 109(15), 2374-2379. CELL PRESS
Digital.CSIC. Repositorio Institucional del CSIC
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Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2bfd05a12c81a1cd11d8bb8178a0953
https://doi.org/10.1016/j.neuron.2021.07.015

Common Pathways in Depression and Obesity: The Role of Gut Microbiome and Diets

Autor: Marie-Ève Tremblay, Astrid M. Westendorf, Dragos Inta, André Schmidt, Andrei-Nicolae Vasilescu, Undine E. Lang, Elisabeth Lang, Alexander Sartorius, Bettina K. Wölnerhanssen, Stefan Borgwardt, Anne S. Mallien, Nina Schweinfurth, Anne Christin Meyer-Gerspach, Peter Gass, Kieran Rea, John F. Cryan

Publikováno v: Current Behavioral Neuroscience Reports. 7:15-21

This paper aims to review data regarding two determinants of comorbidity between depression and obesity, i.e., the role of disturbed gut microbiome in their genesis and of diets in their treatment. Obesity and major depressive disorders (MDD) are hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebb69b1174893010aff45b3e9d2a1a3
https://doi.org/10.1007/s40473-020-00199-1

Cre-activation in ErbB4-positive neurons of floxed Grin1/NMDA receptor mice is not associated with major behavioral impairment

Autor: Peter Gass, Rolf Sprengel, Dragos Inta, Sabine Chourbaji, Miriam A. Vogt, Anne S. Mallien, Natascha Pfeiffer

Publikováno v: Frontiers in Psychiatry
Frontiers in Psychiatry, Vol 12 (2021)

Extensive evidence suggests a dysfunction of the glutamate NMDA receptor (NMDAR) in schizophrenia, a severe psychiatric disorder with putative early neurodevelopmental origins, but clinical onset mainly during late adolescence. On the other hand, pha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7390ed85aa11536d2a34d0a765b25a
https://hdl.handle.net/21.11116/0000-0009-8855-E21.11116/0000-0009-8857-C21.11116/0000-0009-8858-B

Systematic analysis of severity in a widely used cognitive depression model for mice

Autor: Christine Häger, Miriam A. Vogt, Birgitta Struve, Steven R. Talbot, Barbara Vollmayr, Natascha Pfeiffer, Christiane Brandwein, Anne S. Mallien, André Bleich, Peter Gass, Dragos Inta, Rainer Hellweg, Sabine Chourbaji, Rupert Palme

Animal models in psychiatric research are indispensable for insights into mechanisms of behaviour and mental disorders. Distress is an important aetiological factor in psychiatric diseases, especially depression, and is often used to mimic the human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5272c0096b8659994c4a4fb0e56a78eb
http://archiv.ub.uni-heidelberg.de/volltextserver/28468/