Computationally designed Spike antigens induce neutralising responses against the breadth of SARS-COV-2 variants

Autor: Sneha Vishwanath, George William Carnell, Martina Billmeier, Luis Ohlendorf, Patrick Neckermann, Benedikt Asbach, Charlotte George, Maria Suau Sans, Andrew Chan, Joey Olivier, Angalee Nadesalingam, Sebastian Einhauser, Nigel Temperton, Diego Cantoni, Joe Grove, Ingo Jordan, Volker Sandig, Paul Tonks, Johannes Geiger, Christian Dohmen, Verena Mummert, Anne Rosalind Samuel, Christian Plank, Rebecca Kinsley, Ralf Wagner, Jonathan Luke Heeney

Publikováno v: npj Vaccines, Vol 9, Iss 1, Pp 1-9 (2024)

Abstract Updates of SARS-CoV-2 vaccines are required to generate immunity in the population against constantly evolving SARS-CoV-2 variants of concerns (VOCs). Here we describe three novel in-silico designed spike-based antigens capable of inducing n

Externí odkaz: https://doaj.org/article/82ef274560d34dc98c35687c198efcf5

Development and validation of a pre-hospital 'Red Flag' alert for activation of intra-hospital haemorrhage control response in blunt trauma

Autor: Anatole Harrois, Tobias Gauss, Mathieu Raux, Olivier Langeron, Arié Attias, Mathieu Boutonnet, Fabrice Cook, Arnaud Follin, Guillaume de St Maurice, Romain Pirracchio, Catherine Paugam-Burtz, Sophie Hamada, Gilles Dhonneur, Sylvain Ausset, Alexandra Rouquette, Bernard Vigué, Jacques Duranteau, Anne Rosa, Jean-Philippe Desclefs, Bruno Riou

Publikováno v: Critical Care, Vol 22, Iss 1, Pp 1-12 (2018)
Critical Care

Background Haemorrhagic shock is the leading cause of early preventable death in severe trauma. Delayed treatment is a recognized prognostic factor that can be prevented by efficient organization of care. This study aimed to develop and validate Red

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f30d48bbc6a74a0d23ad36d8d4849e8
http://link.springer.com/article/10.1186/s13054-018-2026-9

Implementation of a non-invasive oxygenation support strategy during the COVID-19 pandemic in an ephemeral Respiratory Intermediate Care Unit

Autor: Bénédicte Jeannin, Frédéric J. Mercier, Anne Rosa, Charles Damoisel, Tsipora N Guenancia

Publikováno v: Anaesthesia, Critical Care & Pain Medicine
Anaesthesia Critical Care & Pain Medicine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ec0f32832c67d3e1edb50a759e044f
https://doi.org/10.1016/j.accpm.2020.06.009

pH driven precipitation of quisinostat onto PLA-PEG nanoparticles enables treatment of intracranial glioblastoma

Autor: Kyle T. Householder, Anne Rosa Luning, Eugene P. Chung, Rachael W. Sirianni, Shwetal Mehta, Sarah E. Stabenfeldt, Duong T. Nguyen, Danielle M. DiPerna

Publikováno v: Colloids and surfaces. B, Biointerfaces

Histone deacetylases (HDACs) are known to be key enzymes in cancer development and progression through their modulation of chromatin structure and the expression and post-translational modification of numerous proteins. Aggressive dedifferentiated tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31dce41664748726abb5ef05940755cc
https://pubmed.ncbi.nlm.nih.gov/29533842

Incidence, risk factors and prediction of post-operative acute kidney injury following cardiac surgery for active infective endocarditis: an observational study

Autor: Isabelle Podglajen, Mark J. van der Laan, Jean-Luc Mainardi, Maya L. Petersen, Anne Rosa, Jean-Noël Fabiani, Romain Pirracchio, Matthieu Legrand, D. Safran, Bernard Cholley, Marie-Paule Fernandez-Gerlinger

Publikováno v: Legrand, Matthieu; Pirracchio, Romain; Rosa, Anne; Petersen, Maya L; Van der Laan, Mark; Fabiani, Jean-Noël; et al.(2013). Incidence, risk factors and prediction of post-operative acute kidney injury following cardiac surgery for active infective endocarditis: an observational study. Critical Care, 17(5), R220. doi: http://dx.doi.org/10.1186/cc13041. Retrieved from: http://www.escholarship.org/uc/item/7772k7cj
Critical Care
Critical Care, BioMed Central, 2013, 17 (5), pp.R220. ⟨10.1186/cc13041⟩
Critical Care, BioMed Central, 2013, 17 (5), pp.R220. 〈10.1186/cc13041〉

Introduction Cardiac surgery is frequently needed in patients with infective endocarditis (IE). Acute kidney injury (AKI) often complicates IE and is associated with poor outcomes. The purpose of the study was to determine the risk factors for post-o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21db616f6eb22eb79eb8796deced2990
http://www.escholarship.org/uc/item/7772k7cj