The GPR120 agonist TUG‐891 promotes metabolic health by stimulating mitochondrial respiration in brown fat

Autor: Maaike Schilperoort, Andrea D van Dam, Geerte Hoeke, Irina G Shabalina, Anthony Okolo, Aylin C Hanyaloglu, Lea H Dib, Isabel M Mol, Natarin Caengprasath, Yi‐Wah Chan, Sami Damak, Anne Reifel Miller, Tamer Coskun, Bharat Shimpukade, Trond Ulven, Sander Kooijman, Patrick CN Rensen, Mark Christian

Publikováno v: EMBO Molecular Medicine, Vol 10, Iss 3, Pp 1-18 (2018)

Abstract Brown adipose tissue (BAT) activation stimulates energy expenditure in human adults, which makes it an attractive target to combat obesity and related disorders. Recent studies demonstrated a role for G protein‐coupled receptor 120 (GPR120

Externí odkaz: https://doaj.org/article/435be6144c2f46c4be6f9f0833c44ebc

High Fat Diet Increases Circulating Endocannabinoids Accompanied by Increased Synthesis Enzymes in Adipose Tissue

Autor: Eline N. Kuipers, Vasudev Kantae, Boukje C. Eveleens Maarse, Susan M. van den Berg, Robin van Eenige, Kimberly J. Nahon, Anne Reifel-Miller, Tamer Coskun, Menno P. J. de Winther, Esther Lutgens, Sander Kooijman, Amy C. Harms, Thomas Hankemeier, Mario van der Stelt, Patrick C. N. Rensen, Mariëtte R. Boon

Publikováno v: Frontiers in physiology, 10(JAN):1913. Frontiers Media S.A.
Frontiers in Physiology
Frontiers in Physiology, 9, 1913
Frontiers in Physiology, 9
Frontiers in Physiology, Vol 9 (2019)

The endocannabinoid system (ECS) controls energy balance by regulating both energy intake and energy expenditure. Endocannabinoid levels are elevated in obesity suggesting a potential causal relationship. This study aimed to elucidate the rate of dys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbfd74f64ce4acd3f685d7867f02c4c

The GPR120 agonist TUG‐891 promotes metabolic health by stimulating mitochondrial respiration in brown fat

Autor: Geerte Hoeke, Anne Reifel Miller, Patrick C.N. Rensen, Lea H. Dib, Bharat Shimpukade, Trond Ulven, Tamer Coskun, Anthony Okolo, Sander Kooijman, Maaike Schilperoort, Natarin Caengprasath, Mark Christian, Yi-Wah Chan, Aylin C. Hanyaloglu, Andrea D. van Dam, Sami Damak, Isabel M. Mol, Irina G. Shabalina

Publikováno v: EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 10, Iss 3, Pp n/a-n/a (2018)
EMBO Molecular Medicine, 10(3)
Schilperoort, M, van Dam, A D, Hoeke, G, Shabalina, I G, Okolo, A, Hanyaloglu, A C, Dib, L H, Mol, I M, Caengprasath, N, Chan, Y-W, Damak, S, Miller, A R, Coskun, T, Shimpukade, B, Ulven, T, Kooijman, S, Rensen, P C & Christian, M 2018, ' The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat ', EMBO Molecular Medicine, vol. 10, no. 3, e8047 . https://doi.org/10.15252/emmm.201708047

Brown adipose tissue (BAT) activation stimulates energy expenditure in human adults, which makes it an attractive target to combat obesity and related disorders. Recent studies demonstrated a role for G protein‐coupled receptor 120 (GPR120) in BAT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e500a414f38fbfef93af89f8a97f0493
http://wrap.warwick.ac.uk/97936/1/GPR120-agonist-TUG-391-promotes-Christian-2018.pdf

Short-term cooling increases serum triglycerides and small high-density lipoprotein levels in humans

Autor: Geerte Hoeke, Tamer Coskun, Donna Lee M. Dinnes, Sabine S.C. Norkauer, Philipp Pagel, Jimmy F.P. Berbée, Laurent O. Martinez, Kimberly J. Nahon, Ingrid M. Jazet, Anne Reifel-Miller, Fred P.H.T.M. Romijn, Patrick C.N. Rensen, Maaike Kockx, Mariëtte R. Boon, Christa M. Cobbaert, Leontine E. H. Bakker, Diana Drettwan, Leonard Kritharides, Laeticia Lichtenstein

Publikováno v: Journal of Clinical Lipidology
Journal of Clinical Lipidology, 11(4), 920-928

Background Cold exposure and β3-adrenergic receptor agonism, which both activate brown adipose tissue, markedly influence lipoprotein metabolism by enhancing lipoprotein lipase–mediated catabolism of triglyceride-rich lipoproteins and increasing p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7f86946a712d14b2f96b5373313675
https://hdl.handle.net/1887/115000

The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470)

Autor: Anne Reifel Miller, Marialuisa C. Marcelo, Qi Chen, Ruth Belin, Pranab Maiti, Joseph V. Haas, Jared L. Piper, Ellen A. Cannady, Steven D. Kahl, Anjana Patel Lewis, Guemalli R. Cardona, Jason T. Johnson, D. Scott Coffey, Dawn A. Brooks, James Ficorilli, Xiaosu Ma, Sweetana Stephanie Ann, Chafiq Hamdouchi, Yanyun Chen, Edward J. Pratt, Keyue Chen, Richard W. Zink, Kelly L. Wilbur, Keith A. Otto, Mark A. Deeg, Nathan Yumibe, Jayana Pankaj Lineswala, Thomas E Eessalu, Chahrzad Montrose-Rafizadeh

Publikováno v: Journal of medicinal chemistry. 59(24)

The G protein-coupled receptor 40 (GPR40) also known as free fatty acid receptor 1 (FFAR1) is highly expressed in pancreatic, islet β-cells and responds to endogenous fatty acids, resulting in amplification of insulin secretion only in the presence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e874164fca96fc6edd42ba967fc574b
https://pubmed.ncbi.nlm.nih.gov/27749056