Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Anne R. Gocke"'
Autor:
Lina Hu, Tongguang Wang, Anne R Gocke, Avindra Nath, Hao Zhang, Joseph B Margolick, Katharine A Whartenby, Peter A Calabresi
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54267 (2013)
Increased expression of the voltage-gated potassium channel Kν1.3 on activated effector memory T cells (T(EM)) is associated with pathology in multiple sclerosis (MS). To date, most studies of Kν1.3 channels in MS have focused on CD4+ T(EM) cells.
Externí odkaz:
https://doaj.org/article/b1b3d33c05f240149ec6d3c82d1de096
Publikováno v:
PPAR Research, Vol 2008 (2008)
Externí odkaz:
https://doaj.org/article/f4e57f757e84497d98a99a22434caec7
Autor:
Anne R. Gocke, Jasenka Borzan, Peter A. Calabresi, Aniqa Tasnim, Lijuan Liu, John A. Fissel, Mohamed H. Farah
Publikováno v:
Neurobiology of Disease, Vol 93, Iss, Pp 21-27 (2016)
Hematogenous macrophages remove myelin debris from injured peripheral nerves to provide a micro-environment conducive to axonal regeneration. Previously, we observed that injured peripheral nerves from Beta-site APP Cleaving Enzyme 1 (BACE1) knockout
Autor:
Christopher Eckstein, Ellen M. Mowry, Lawrence Steinman, Moira Baynes, Achilles Ntranos, Peter A. Calabresi, Elias S. Sotirchos, Anne R. Gocke, Pavan Bhargava, Keith Van Haren
Publikováno v:
Neurology. 86:382-390
Objective: To study the safety profile and characterize the immunologic effects of high- vs low-dose cholecalciferol supplementation in patients with multiple sclerosis (MS). Methods: In this double-blind, single-center randomized pilot study, 40 pat
Publikováno v:
Journal of Neuroimmunology. 279:20-24
Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studi
Autor:
Inna V. Grishkan, Dominique M. Tosi, Achilles Ntranos, Dionne P. Robinson, Anne R. Gocke, Sabra L. Klein, Peter A. Calabresi, Olivia J. Hall, Jason T. Schott
Publikováno v:
Journal of Neuroimmunology. 270:13-21
Fingolimod (FTY720) is a multiple sclerosis (MS) therapeutic that upon phosphorylation causes the internalization of sphingosine-1-phosphate receptors (S1PR) and traps CCR7+ T-cells in lymph nodes but relatively spares CCR7-effector T-cells. Nonethel
Publikováno v:
Proceedings of the National Academy of Sciences. 110:21101-21106
Pharmacologic targeting of T helper (TH) cell trafficking poses an attractive opportunity for amelioration of autoimmune diseases such as multiple sclerosis (MS). MS risk is associated with vitamin D deficiency, and its bioactive form, 1,25-dihydroxy
Autor:
Lori Lebson, Hai M. Nguyen, Katharine A. Whartenby, Inna V. Grishkan, Peter A. Calabresi, K. George Chandy, Anne R. Gocke, Lina Hu
Publikováno v:
The Journal of Immunology. 188:5877-5886
Increasing evidence suggests ion channels have critical functions in the differentiation and plasticity of T cells. Kv1.3, a voltage-gated K+ channel, is a functional marker and a pharmacological target for activated effector memory T cells. Selectiv
Autor:
Christina Kellerer, Susanne Feil, Ivana Glocova, Jürgen Brück, Nadejda Valtcheva, Rehana Z. Hussain, Annedore Respa, Amy E. Lovett-Racke, Kamran Ghoreschi, Michael K. Racke, Ralf Dringen, Eva Alexander, Klaus Schulze-Osthoff, Martin Röcken, Anne R. Gocke, Caishu Deng, Robert Feil, Oliver Rothfuss, Rudolf A. Rupec, Haiyan Peng
Publikováno v:
Journal of Experimental Medicine; Vol 208
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Fumarates suppress Th1 responses by blocking IL-12 and IL-23 production by dendritic cells via distinct pathways.
Fumarates improve multiple sclerosis (MS) and psoriasis, two diseases in which both IL-12 and IL-23 promote pathogenic T helper (Th
Fumarates improve multiple sclerosis (MS) and psoriasis, two diseases in which both IL-12 and IL-23 promote pathogenic T helper (Th
Autor:
Katharine A. Whartenby, Jason M. Rosenzweig, Peter A. Calabresi, Jonathan K. Alder, Curt I. Civin, Anne R. Gocke, Lori Lebson
Publikováno v:
The Journal of Immunology. 185:7161-7164
Th17 cells play a significant role in inflammatory and autoimmune responses. Although a number of molecular pathways that contribute to the lineage differentiation of T cells have been discovered, the mechanisms by which lineage commitment occurs are