Výsledky vyhledávání - "Anne Quillet-Mary"

Akademický článek

New pharmacodynamic parameters linked with ibrutinib responses in chronic lymphocytic leukemia: Prospective study in real-world patients and mathematical modeling.

Autor: Sarah Cadot, Chloe Audebert, Charlotte Dion, Soleakhena Ken, Loic Dupré, Laetitia Largeaud, Camille Laurent, Loic Ysebaert, Fabien Crauste, Anne Quillet-Mary

Publikováno v: PLoS Medicine, Vol 21, Iss 7, p e1004430 (2024)

BackgroundOne of the first clinical observations of ibrutinib activity in the treatment of chronic lymphocytic leukemia (CLL) is a rapid decline in lymph nodes size. This phenomenon is accompanied by an hyperlymphocytosis, either transient or prolong

Externí odkaz: https://doaj.org/article/f17d8dafc0d34daa9927d03be3be13de

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Akademický článek

Lymphocyte migration and retention properties affected by ibrutinib in chronic lymphocytic leukemia

Autor: Javier Rey-Barroso, Alice Munaretto, Nelly Rouquié, Aurélie Mougel, Malika Chassan, Sébastien Gadat, Océane Dewingle, Renaud Poincloux, Sarah Cadot, Loïc Ysebaert, Anne Quillet-Mary, Loïc Dupré

Publikováno v: Haematologica, Vol 109, Iss 3 (2023)

The Bruton tyrosine kinase (BTK) inhibitor ibrutinib is widely used for treatment of patients with relapsed/refractory or treatment-naïve chronic lymphocytic leukemia (CLL). A prominent effect of ibrutinib is to disrupt the retention of CLL cells fr

Externí odkaz: https://doaj.org/article/29c100f1121c45a9b80d70916791602f

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Akademický článek

Longitudinal CITE-Seq profiling of chronic lymphocytic leukemia during ibrutinib treatment: evolution of leukemic and immune cells at relapse

Autor: Sarah Cadot, Carine Valle, Marie Tosolini, Frederic Pont, Laetitia Largeaud, Camille Laurent, Jean Jacques Fournie, Loic Ysebaert, Anne Quillet-Mary

Publikováno v: Biomarker Research, Vol 8, Iss 1, Pp 1-13 (2020)

Abstract Background Ibrutinib, an irreversible Bruton Tyrosine Kinase (BTK) inhibitor, has revolutionized Chronic Lymphocytic Leukemia (CLL) treatment, but resistances to ibrutinib have emerged, whether related or not to BTK mutations. Patterns of CL

Externí odkaz: https://doaj.org/article/e2fc737158c04f7ba4a2fdea4933707f

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Akademický článek

Lymphoma Heterogeneity Unraveled by Single-Cell Transcriptomics

Autor: Loic Ysebaert, Anne Quillet-Mary, Marie Tosolini, Frederic Pont, Camille Laurent, Jean-Jacques Fournié

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

High-definition transcriptomic studies through single-cell RNA sequencing (scRNA-Seq) have revealed the heterogeneity and functionality of the various microenvironments across numerous solid tumors. Those pioneer studies have highlighted different ce

Externí odkaz: https://doaj.org/article/5381e4055ad240e4af7ab5295a907b0c

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Akademický článek

Phased differentiation of γδ T and T CD8 tumor-infiltrating lymphocytes revealed by single-cell transcriptomics of human cancers

Autor: Juan-Pablo Cerapio, Marion Perrier, Camille-Charlotte Balança, Pauline Gravelle, Fréderic Pont, Christel Devaud, Don-Marc Franchini, Virginie Féliu, Marie Tosolini, Carine Valle, Fréderic Lopez, Anne Quillet-Mary, Loic Ysebaert, Alejandra Martinez, Jean Pierre Delord, Maha Ayyoub, Camille Laurent, Jean-Jacques Fournie

Publikováno v: OncoImmunology, Vol 10, Iss 1 (2021)

γδ T lymphocytes diverge from conventional T CD8 lymphocytes for ontogeny, homing, and antigen specificity, but whether their differentiation in tumors also deviates was unknown. Using innovative analyses of our original and ~150 published single-c

Externí odkaz: https://doaj.org/article/78cd3c370634474b9f9993cdc250af9f

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Akademický článek

DNA polymerase ν gene expression influences fludarabine resistance in chronic lymphocytic leukemia independently of p53 status

Autor: Srdana Grgurevic, Patricia Montilla-Perez, Alice Bradbury, Julia Gilhodes, Sophie Queille, Sandrine Pelofy, Aurélien Bancaud, Thomas Filleron, Loïc Ysebaert, Christian Récher, Guy Laurent, Jean-Jacques Fournié, Christophe Cazaux, Anne Quillet-Mary, Jean-Sébastien Hoffmann

Publikováno v: Haematologica, Vol 103, Iss 6 (2018)

Alteration in the DNA replication, repair or recombination processes is a highly relevant mechanism of genomic instability. Despite genomic aberrations manifested in hematologic malignancies, such a defect as a source of biomarkers has been underexpl

Externí odkaz: https://doaj.org/article/fb475d78aec04e248a296855f47de9e2

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Akademický článek

Prognostic role of CD4 T-cell depletion after frontline fludarabine, cyclophosphamide and rituximab in chronic lymphocytic leukaemia

Autor: Martin Gauthier, Françoise Durrieu, Elodie Martin, Michael Peres, François Vergez, Thomas Filleron, Lucie Obéric, Fontanet Bijou, Anne Quillet Mary, Loic Ysebaert

Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019)

Abstract Background Eradication of minimal residual disease (MRD), at the end of Fludarabine-Cyclophosphamide-Rituximab (FCR) treatment, is a validated surrogate marker for progression-free and overall survival in chronic lymphocytic leukaemia. But s

Externí odkaz: https://doaj.org/article/ca51332e1168470592babd22abe18c80

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Phased differentiation of γδ T and T CD8 tumorinfiltrating lymphocytes revealed by single-cell transcriptomics of human cancers

Autor: Pauline Gravelle, Marie Tosolini, Juan-Pablo Cerapio, Frédéric Pont, Maha Ayyoub, Camille Laurent, Virginie Féliu, Carine Valle, Anne Quillet-Mary, Alejandra Martinez, Loic Ysebaert, Camille-Charlotte Balança, Christel Devaud, Jean-Jacques Fournié, Don-Marc Franchini, Frédéric Lopez, Marion Perrier, Jean Pierre Delord

Publikováno v: OncoImmunology
OncoImmunology, Taylor & Francis, In press, ⟨10.1080/2162402X.2021.1939518⟩
OncoImmunology, 2021, 10 (1), ⟨10.1080/2162402X.2021.1939518⟩
OncoImmunology, Taylor & Francis, 2021, 10 (1), ⟨10.1080/2162402X.2021.1939518⟩
OncoImmunology, Vol 10, Iss 1 (2021)
OncoImmunology, In press, ⟨10.1080/2162402X.2021.1939518⟩
Oncoimmunology
article-version (VoR) Version of Record

International audience; γδ T lymphocytes diverge from conventional T CD8 lymphocytes for ontogeny, homing, and antigen specificity, but whether their differentiation in tumors also deviates was unknown. Using innovative analyses of our original and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa0d5a3a131f13bd759f5f6c38604df
https://hal.archives-ouvertes.fr/hal-03365502/document

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Population Pharmacokinetics of Ibrutinib and Its Dihydrodiol Metabolite in Patients with Lymphoid Malignancies

Autor: Caroline Protin, Fanny Gallais, Ben Allal, Sandra De Barros, Fabienne Thomas, Anne Quillet-Mary, Melanie White-Koning, Etienne Chatelut, Lucie Oberic, Loïc Dupré, Fabien Despas, Loïc Ysebaert

Publikováno v: Clinical Pharmacokinetics
Clinical Pharmacokinetics, 2020, 59 (9), pp.1171-1183. ⟨10.1007/s40262-020-00884-0⟩
Clinical Pharmacokinetics, Springer Verlag, 2020, 59 (9), pp.1171-1183. ⟨10.1007/s40262-020-00884-0⟩

Ibrutinib is used for the treatment of chronic lymphocytic leukemia and other lymphoid malignancies. The aim of this work is to develop a population pharmacokinetic model for ibrutinib and its dihydrodiol metabolite to quantify pharmacokinetic inter-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18466632280bd56f9f163b49b4fa5076
https://hal.science/hal-02989879/document

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