Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Anne Quesnel-Hellmann"'
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43266 (2012)
Bacillus anthracis, the agent of anthrax, produces two main virulence factors: a capsule and two toxins. Both lethal toxin (LT) and edema toxin (ET) paralyze the immune defense system. Here, we analyze the effects of LT and ET on the capacity of huma
Externí odkaz:
https://doaj.org/article/947c082d161f4eaa854fd2a3bd078e1e
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39831 (2012)
Dendritic Cells (DC) represent a key lung immune cell population, which play a critical role in the antigen presenting process and initiation of the adaptive immune response. The study of DCs has largely benefited from the joint development of fluore
Externí odkaz:
https://doaj.org/article/b3e2b509bf564077a19116313b5f0820
Publikováno v:
PLoS Pathogens, Vol 2, Iss 5, p e44 (2006)
Externí odkaz:
https://doaj.org/article/7160973eeecb4221aff18883e642dc48
Autor:
Jacques Mathieu, Jean-Nicolas Tournier, Kévin Garraud, Daniel Fiole, Yves P. Gauthier, Anne Quesnel-Hellmann, Aurélie Cleret
Publikováno v:
Infection and Immunity. 80:131-142
The roles of interleukin-17 (IL-17) and neutrophils in the lung have been described as those of two intricate but independent players. Here we identify neutrophils as the primary IL-17-secreting subset of cells in a model of inhalation anthrax using
Autor:
Mansour Mohamadzadeh, Jean-Nicolas Tournier, Bradley G. Stiles, Robert G. Ulrich, Anne Quesnel-Hellmann
Publikováno v:
Expert Review of Anti-infective Therapy. 7:219-236
Bacillus anthracis is the causative agent of anthrax, a disease that plagues both humans and various animal species. Effective vaccines are available, but those approved for human use are crude culture supernatants that require multiple injections an
Autor:
Jacques Mathieu, Steffen Jung, Jean-Nicolas Tournier, Bernard Verrier, Anne Quesnel-Hellmann, Aurélie Cleret, Alexandra Vallon-Eberhard, Dominique R. Vidal
Publikováno v:
The Journal of Immunology. 178:7994-8001
Inhalational anthrax is a life-threatening infectious disease of considerable concern, especially because anthrax is an emerging bioterrorism agent. The exact mechanisms leading to a severe clinical form through the inhalational route are still uncle
Publikováno v:
Cellular Microbiology. 9:555-565
Summary Inhalational anthrax is a life-threatening infectious disease of considerable concern, especially as a potential bioterrorism agent. Progress is gradually being made towards understanding the mechanisms used by Bacillus anthracis to escape th
Autor:
Jacques Mathieu, Jean-Nicolas Tournier, Anne Quesnel-Hellmann, Dominique R. Vidal, Aurélie Cleret
Publikováno v:
The Journal of Infectious Diseases. 194:86-94
Bacillus anthracis secretes 2 toxins: lethal toxin (LT) and edema toxin (ET). We investigated their role in the physiopathologic mechanisms of inhalational anthrax by evaluating murine lung dendritic cell (LDC) functions after infection with B. anthr
Publikováno v:
Vaccine. 24:699-702
Bacillus anthracis edema factor (EF) is an adenylate cyclase that increases intracellular cAMP concentrations. Since EF is present as a contaminant in the licensed protective antigen(PA)-based vaccines, we investigated its effect on anti-PA humoral i
Autor:
Jacques Mathieu, Pierre L. Goossens, Michèle Mock, Anne Quesnel-Hellmann, Dominique R. Vidal, Jean-Nicolas Tournier, Aurélie Cleret
Publikováno v:
Bulletin de l'Académie Nationale de Médecine. 190:155-167
RESUME L’utilisation de spores de Bacillus anthracis lors des attaques bioterroristes recentes a ete a l’origine de plusieurs cas de charbon d’inhalation, soulignant les besoins croissant dans la comprehension de la physiopathologie de la malad