Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Anne Pharo"'
Autor:
Bernt Christian Hellerud, Morten Harboe, Kristina Nilsson Ekdahl, Christina Johnson, Stig Haugset Nymo, Karin Ekholt, Anne Pharo, Camilla Schjalm, Julie Katrine Lindstad, Tom Eirik Mollnes, Per H. Nilsson
Publikováno v:
E534-E539
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Source at https://doi.org/10.1073/pnas.1612385114. Two functions have been assigned to properdin; stabilization of the alternative convertase, C3bBb, is well accepted, whereas the role of properdin as pattern recognition molecule is controversial. Th
Autor:
Kjetil H. Egge, Tom Eirik Mollnes, Julie Katrine Lindstad, Anne Pharo, Ebbe Billmann Thorgersen, John D. Lambris, Andreas Barratt-Due
Publikováno v:
Innate Immunity. 20:68-77
Combined inhibition of CD14 and complement, two main inducers of the inflammatory response, have proved particularly effective in attenuating Gram-negative bacteria-induced inflammation. Approaching possible clinical relevance, we investigated the ef
Autor:
Ebbe Billmann Thorgersen, Andrey Sokolov, Kjetil H. Egge, Bernt Christian Hellerud, Anne Pharo, Julie Katrine Lindstad, Alice Gustavsen, Soeren Erik Pischke, Tom Eirik Mollnes, Albert Castellheim, Andreas Barratt-Due
Publikováno v:
Immunobiology. 218:683-689
Evidence suggests that adjunctive treatment with intravenous immunoglobulin preparations enriched with IgA and IgM reduce mortality in sepsis. The mode of action of polyvalent immunoglobulin is complex, including neutralization of toxins and modulati
Autor:
Tor Inge Tønnessen, Håkon Haugaa, Kirsten Muri Boberg, Guro Grindheim, Pål-Dag Line, Soeren Erik Pischke, Aksel Foss, Lars Wælgaard, Ebbe Billmann Thorgersen, Runar Almaas, Tom Eirik Mollnes, Anne Pharo, Truls Sanengen
Publikováno v:
Liver Transplantation. 18:1421-1429
Rejection and ischemia are serious complications after liver transplantation. Early detection is mandatory, but specific markers are largely missing, particularly for rejection. The objective of this study was to explore the ability of microdialysis
Autor:
Gregory L. Stahl, Anne Pharo, Peter Garred, Julie Katrine Lindstad, John D. Lambris, Morten Harboe, Fredrik Müller, Tom Eirik Mollnes
Publikováno v:
The Journal of Immunology. 189:2606-2613
Properdin is well known as an enhancer of the alternative complement amplification loop when C3 is activated, whereas its role as a recognition molecule of exogenous pathogen-associated molecular patterns and initiator of complement activation is les
Autor:
Håkon Haugaa, Guro Grindheim, Tor Inge Tønnessen, Kirsten Muri Boberg, Ebbe Billmann Thorgersen, Anne Pharo, Pål-Dag Line, Tom Eirik Mollnes, Truls Sanengen, Runar Almaas, Soeren Erik Pischke, Aksel Foss
Publikováno v:
Liver Transplantation. 18:839-849
This study was performed to explore whether lactate, pyruvate, glucose, and glycerol levels sampled via microdialysis catheters in the transplanted liver could be used to detect ischemia and/or rejection. The metabolites were measured at the bedside
Autor:
Petter Brandtzaeg, Dorte Christiansen, Bernt Christian Hellerud, Julie Katrine Lindstad, Ole-Lars Brekke, John D. Lambris, Graham Leslie, Grethe Bergseth, Albert Castellheim, Tom Eirik Mollnes, Erik Waage Nielsen, Hilde Fure, Anne Pharo
Publikováno v:
Brekke, O L, Hellerud, B C, Christiansen, D, Fure, H, Castellheim, A, Nielsen, E W, Pharo, A, Lindstad, J K, Bergseth, G, Leslie, G, Lambris, J D, Brandtzaeg, P & Mollnes, T E 2011, ' Neisseria meningitidis and Escherichia coli are protected from leukocyte phagocytosis by binding to erythrocyte complement receptor 1 in human blood ', Molecular Immunology, vol. 48, no. 15-16, pp. 2159-2169 . https://doi.org/10.1016/j.molimm.2011.07.011
The initial interaction of Gram-negative bacteria with erythrocytes and its implications on leukocyte phagocytosis and oxidative burst in human whole blood were examined. Alexa-labeled Escherichia coli, wild-type H44/76 N. meningitidis and the H44/76
Autor:
Tom Eirik Mollnes, Ebbe Billmann Thorgersen, Andreas Barratt-Due, Anne Pharo, Julie Katrine Lindstad, John D. Lambris, Dorte Christiansen, Ole-Lars Brekke
Publikováno v:
Molecular Immunology. 47:1774-1782
Inhibition of the inappropriate and excessive inflammatory response has been a main issue in sepsis-related research. Historically, TNF-alpha and IL-1 beta have been postulated as key mediators in sepsis, but selective inhibition of these cytokines h
Autor:
Georgia Sfyroera, Peter Gaustad, Anne Pharo, Ebbe Billmann Thorgersen, Tom Eirik Mollnes, Girish J. Kotwal, Karin Haverson, Anne K. Axelsen
Publikováno v:
Infection and Immunity. 77:725-732
The innate immune response is a double-edged sword in systemic inflammation and sepsis. Uncontrolled or inappropriate activation can damage and be lethal to the host. Several studies have investigated inhibition of downstream mediators, including tum
Autor:
Anne Pharo, Dorte Christiansen, Johan Riesenfeld, Tom Eirik Mollnes, Michael Fung, Hilde Fure, Ole-Lars Brekke
Publikováno v:
Molecular Immunology. 45:3804-3813
The relative role of complement and CD14 in E. coli-induced cytokine synthesis in an in vitro human whole blood model of sepsis was examined. Fresh lepirudin-anticoagulated whole blood was incubated with E. coli for 2h. Monoclonal antibodies or a C5a