Supplementary Figures 1-9 from Telomere Targeting with a New G4 Ligand Enhances Radiation-Induced Killing of Human Glioblastoma Cells

Autor: Andreï Tchirkov, Pierre Verrelle, Jean-Louis Mergny, Phong Lan Thao Tran, Lionel Guittat, Anne De Cian, Emmanuel Chautard, Marie-Paule Teulade-Fichou, Jean-Marie Lehn, Anne Petitjean, Bertrand Evrard, Patrick Merle

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2f063260d3a8d034598a8e25299e5c
https://doi.org/10.1158/1535-7163.22496886.v1

Data from Telomere Targeting with a New G4 Ligand Enhances Radiation-Induced Killing of Human Glioblastoma Cells

Autor: Andreï Tchirkov, Pierre Verrelle, Jean-Louis Mergny, Phong Lan Thao Tran, Lionel Guittat, Anne De Cian, Emmanuel Chautard, Marie-Paule Teulade-Fichou, Jean-Marie Lehn, Anne Petitjean, Bertrand Evrard, Patrick Merle

The aim of this study was to test in vitro the efficacy of TAC, an original G-quadruplex ligand, as a potential radiosensitizing agent for glioblastoma multiforme (GBM). Two human radioresistant telomerase-positive GBM cell lines (SF763 and SF767) we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::893d5c5098816cb838f7a5a6f683ce3e
https://doi.org/10.1158/1535-7163.c.6535419

Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution‐ and Solid‐State Investigations

Autor: Alana M. M. Rangaswamy, Zongchao Jia, Caitlin E. Miron, Laura M. van Staalduinen, Mickey Chen, Yushi Liang, Anne Petitjean, Jean-Louis Mergny

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2020, Online ahead of print. ⟨10.1002/anie.202012520⟩
Angewandte Chemie International Edition, 2020, Online ahead of print. ⟨10.1002/anie.202012520⟩

International audience; Guanine quadruplex recognition has gained increasing attention, inspired by the growing awareness of the key roles played by these non-canonical nucleic acid architectures in cellular regulatory processes. We report here the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a9718f4deff99e8008f6ac17534b62
https://www.hal.inserm.fr/inserm-02976985

To Loop or Not to Loop: Influence of Hinge Flexibility on Self-Assembly Outcomes for Acridine-Based Triazolylpyridine Chelates with Zinc(II), Iron(II), and Copper(II)

Autor: Caitlin E. Miron, Anne Petitjean, Olivier Fleischel

Publikováno v: Chemistry - A European Journal. 24:17318-17326

Coordination-driven self-assembly has been established as an effective strategy for the efficient construction of intricate architectures in both natural and artificial systems, for applications ranging from gene regulation to metal-organic framework

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::431c957fa96acebeaf9c6663a2ec5222
https://doi.org/10.1002/chem.201803732

Fac vs Mer Selection in Octahedral Complexes of the N-Benzyl-Substituted Triazolylpyridine Diad with Labile Metal Ions (Zinc(II), Iron(II), and Nickel(II))

Autor: Gabriele Schatte, Nan Wu, Mona AshrafKhorasani, Anne Petitjean, Olivier Fleischel

Publikováno v: Crystal Growth & Design. 18:1517-1525

Pseudo-octahedral complexes built on chelating ligands offer valuable isomeric properties such as the formation of fac vs mer isomers, and Λ vs Δ enantiomers. This article discusses factors guiding the fac vs mer selection of complexes built from t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01bc1179a6ca8be57d470b898ad55e00
https://doi.org/10.1021/acs.cgd.7b01495