Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Anne Pak"'
Autor:
Y. Anne Pak, Maria M. Posada, James Bacon, Amanda Long, William Annes, Jennifer Witcher, Malcolm Mitchell, Rommel G. Tirona, Stephen D. Hall, Kathleen M. Hillgren
Publikováno v:
Pharmaceutical Research.
Autor:
James A. Bacon, Palaniappan Kulanthaivel, Joseph V. Bonventre, Alan Y. Chiang, Y. Anne Pak, Stephen D. Hall, Jane Royalty, P. Kellie Turner, Jill Chappell
Publikováno v:
Clinical Pharmacology and Therapeutics
Abemaciclib, an inhibitor of cyclin dependent kinases 4 and 6, is indicated for metastatic breast cancer treatment. Reversible increases in serum creatinine levels of ~15-40% over baseline have been observed following abemaciclib dosing. This study a
Autor:
Maria M. Posada, Christopher D. Payne, Xin Zhang, Stephen D. Hall, J. William Higgins, Ellen A. Cannady, Y. Anne Pak, Nazila Shahri, Kathleen M. Hillgren, James A. Bacon
Publikováno v:
Clinical and Translational Science
Baricitinib, an oral selective Janus kinase 1 and 2 inhibitor, undergoes active renal tubular secretion. Baricitinib was not predicted to inhibit hepatic and renal uptake and efflux drug transporters, based on the ratio of the unbound maximum elimina
Autor:
Jayakumar Surendradoss, Kathleen M. Hillgren, Jiabin Qiu, Anthony Borel, Richard Moulton, Lisa Chen, Jeff Alberts, Cydney M. Martell, Anne Pak, Yingyin Guo, Michael A. Mohutsky, Celia Ochoa
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S63-S64
Autor:
Mary Pat Knadler, William F. Annes, Amanda J. Long, Kathleen M. Hillgren, Jennifer Witcher, Y. Anne Pak, Malcolm I. Mitchell, Phillip Leese, Mosun Ayan-Oshodi
Publikováno v:
Drug Metabolism and Disposition
Despite peptide transporter 1 (PEPT1) being responsible for the bioavailability for a variety of drugs, there has been little study of its potential involvement in drug-drug interactions. Pomaglumetad methionil, a metabotropic glutamate 2/3 receptor
Autor:
Joseph W. Polli, Jonathan Maher, Kunal S Taskar, A. David Rodrigues, Christoph Funk, Michael J. Hafey, Robert W. Yucha, Kim L. R. Brouwer, Y. Anne Pak, Paul B. Watkins, David Dai, Jenny M. Pedersen, David L. Bourdet, Kyunghee Yang, Christina Battista, J. Gerry Kenna, Yurong Lai, Kenneth R. Brouwer
Publikováno v:
Clinical Pharmacology and Therapeutics
Bile salt export pump (BSEP) inhibition has emerged as an important mechanism that may contribute to the initiation of human drug-induced liver injury (DILI). Proactive evaluation and understanding of BSEP inhibition is recommended in drug discovery
Autor:
J. William Higgins, Rommel G. Tirona, Karen B. Schneck, Stephen D. Hall, Maria M. Posada, Richard B. Kim, Y. Anne Pak, Kathleen M. Hillgren, James A. Bacon
Publikováno v:
Drug Metabolism and Disposition. 43:325-334
Pemetrexed, an anionic anticancer drug with a narrow therapeutic index, is eliminated mainly by active renal tubular secretion. The in vitro to in vivo extrapolation approach used in this work was developed to predict possible drug-drug interactions
Autor:
Laurent Salphati, Eric Sands, Praveen Balimane, Caroline A. Lee, Johan E. Palm, Joe Bentz, Lalitha Podila, Jesse Taur, Tetsuo Yamagata, Lei K. Zhang, Kathleen M. Hillgren, Eric L. Reyner, Marie Brännström, Dietmar Weitz, Emile Plise, Jocelyn Yabut, Masoud Jamei, Harma Ellens, Anne Pak, Dallas Bednarczyk, Guangqing Xiao, Mitchell E. Taub, Libin Li, Heleen M. Wortelboer, Elke S Perloff, Andrew K Mason, Michael P. O'Connor, Krisztina Herédi-Szabó, Aarti Patel, Ganesh Rajaraman, Xiaoyan Chu, Evelyn Hollnack-Pusch, Christoph Funk, Joann Coleman, Cindy Q. Xia, Xuena Lin, Imad Hanna, Ailan Guo, Sibylle Neuhoff
Publikováno v:
Drug Metabolism and Disposition. 41:1347-1366
A P-glycoprotein (P-gp) IC₅₀ working group was established with 23 participating pharmaceutical and contract research laboratories and one academic institution to assess interlaboratory variability in P-gp IC₅₀ determinations. Each laboratory
Publikováno v:
Pharmaceutical Research. 15:706-711
Purpose. Drug disposition is often altered in inflammatory disease. Although the influence of inflammation on hepatic drug metabolism and protein binding has been well studied, its impact on drug transport has largely been overlooked. The multidrug r
Publikováno v:
MILCOM 2009 - 2009 IEEE Military Communications Conference.
Link margin specification based on worst case link conditions is conservative and virtually guarantees increased costs and over-design of satellite hardware just to ensure that the worst case link meets requirements. One approach to optimize performa