Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Anne P. Ferguson"'
Autor:
Risha Amarsi, Samuel Furse, Mary A. M. Cleaton, Sarah Maurel, Alice L. Mitchell, Anne C. Ferguson-Smith, Nicolas Cenac, Catherine Williamson, Albert Koulman, Marika Charalambous
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The long and very long chain polyunsaturated fatty acids (LC-PUFAs) are preferentially transported by the mother to the fetus. Failure to supply LC-PUFAs is strongly linked with stillbirth, fetal growth restriction, and impaired neurodevelop
Externí odkaz:
https://doaj.org/article/3576b3f3545c494289c5656af0cfc34b
Autor:
Coby Viner, Charles A. Ishak, James Johnson, Nicolas J. Walker, Hui Shi, Marcela K. Sjöberg-Herrera, Shu Yi Shen, Santana M. Lardo, David J. Adams, Anne C. Ferguson-Smith, Daniel D. De Carvalho, Sarah J. Hainer, Timothy L. Bailey, Michael M. Hoffman
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-46 (2024)
Abstract Background Transcription factors bind DNA in specific sequence contexts. In addition to distinguishing one nucleobase from another, some transcription factors can distinguish between unmodified and modified bases. Current models of transcrip
Externí odkaz:
https://doaj.org/article/e7bb424ddc9949f19963f6d42c94377b
Autor:
Amir D. Hay, Noah J. Kessler, Daniel Gebert, Nozomi Takahashi, Hugo Tavares, Felipe K. Teixeira, Anne C. Ferguson-Smith
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract DNA methylation at the CpG dinucleotide is considered a stable epigenetic mark due to its presumed long-term inheritance through clonal expansion. Here, we perform high-throughput bisulfite sequencing on clonally derived somatic cell lines t
Externí odkaz:
https://doaj.org/article/e2316b0d639a469ead1b7754816be313
Autor:
Geula Hanin, Anne C. Ferguson‐Smith
Publikováno v:
FEBS Open Bio, Vol 13, Iss 7, Pp 1218-1227 (2023)
The mammary gland is a vital exocrine organ that has evolved in mammals to secrete milk and provide nutrition to ensure the growth and survival of the neonate The mouse mammary gland displays extraordinary plasticity each time the female undergoes pr
Externí odkaz:
https://doaj.org/article/71d0b8e3e10c4562b3d7ea6e72e5a0f2
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Genomic imprinting is an epigenetic process whereby genes are monoallelically expressed in a parent-of-origin-specific manner. Imprinted genes are frequently found clustered in the genome, likely illustrating their need for both shared regulatory con
Externí odkaz:
https://doaj.org/article/830e3195b57543f98f3c604b36e574b8
Autor:
Ariella Weinberg-Shukron, Raz Ben-Yair, Nozomi Takahashi, Marko Dunjić, Alon Shtrikman, Carol A. Edwards, Anne C. Ferguson-Smith, Yonatan Stelzer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Here the authors investigate whether for imprinted genes the parent-of-origin of the expressed allele or rather appropriate gene dosage is more important for normal development. Using the differentially methylated region of Dlk1-Dio3 gene involved in
Externí odkaz:
https://doaj.org/article/3c2e572b6cb84eb0b0fe93786cb692ef
Autor:
Carol A Edwards, William MD Watkinson, Stephanie B Telerman, Lisa C Hulsmann, Russell S Hamilton, Anne C Ferguson-Smith
Publikováno v:
eLife, Vol 12 (2023)
In mouse and human, genes subjected to genomic imprinting have been shown to function in development, behavior, and post-natal adaptations. Failure to correctly imprint genes in human is associated with developmental syndromes, adaptive, and metaboli
Externí odkaz:
https://doaj.org/article/13033a2ac6d44daebe192428a6bf7da2
Autor:
Mathew Van de Pette, Andrew Dimond, António M. Galvão, Steven J. Millership, Wilson To, Chiara Prodani, Gráinne McNamara, Ludovica Bruno, Alessandro Sardini, Zoe Webster, James McGinty, Paul M. W. French, Anthony G. Uren, Juan Castillo-Fernandez, William Watkinson, Anne C. Ferguson-Smith, Matthias Merkenschlager, Rosalind M. John, Gavin Kelsey, Amanda G. Fisher
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Here the authors show that a high-fat diet in pregnant mice can release silencing of the imprinted Dlk1 locus in multiple generations of offspring. They found that this occurs via changes in microRNA expression at the locus of interest, as well as tr
Externí odkaz:
https://doaj.org/article/21c5cdaf517b495e8f2f75239a9fefc7
Autor:
Georgina E. T. Blake, Xiaohui Zhao, Hong wa Yung, Graham J. Burton, Anne C. Ferguson-Smith, Russell S. Hamilton, Erica D. Watson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Abnormal folate metabolism in mice results in transgenerational epigenetic inheritance of congenital malformations. Here, the authors provide evidence that defective folate metabolism causes germline epigenetic instability and observe multigeneration
Externí odkaz:
https://doaj.org/article/a2b6f87964694b4bad4140b486ce7efe
Autor:
Jessica L. Elmer, Amir D. Hay, Noah J. Kessler, Tessa M. Bertozzi, Eve A. C. Ainscough, Anne C. Ferguson-Smith
Publikováno v:
Mobile DNA, Vol 12, Iss 1, Pp 1-16 (2021)
Abstract Background Transposable elements (TEs) are enriched in cytosine methylation, preventing their mobility within the genome. We previously identified a genome-wide repertoire of candidate intracisternal A particle (IAP) TEs in mice that exhibit
Externí odkaz:
https://doaj.org/article/adf7dc0066924ceb83c4919b87a03967