Výsledky vyhledávání - "Anne P Beigneux"

Akademický článek

Quantification of lipoprotein lipase in mouse plasma with a sandwich enzyme-linked immunosorbent assay

Autor: Takao Kimura, Kazuya Miyashita, Isamu Fukamachi, Kumiko Fukamachi, Kazumi Ogura, Erina Yokoyama, Katsuhiko Tsunekawa, Takumi Nagasawa, Michael Ploug, Ye Yang, Wenxin Song, Stephen G. Young, Anne P. Beigneux, Katsuyuki Nakajima, Masami Murakami

Publikováno v: Journal of Lipid Research, Vol 65, Iss 4, Pp 100532- (2024)

To support in vivo and in vitro studies of intravascular triglyceride metabolism in mice, we created rat monoclonal antibodies (mAbs) against mouse LPL. Two mAbs, mAbs 23A1 and 31A5, were used to develop a sandwich ELISA for mouse LPL. The detection

Externí odkaz: https://doaj.org/article/7bb09355127f4c74a78df72318b9d2fc

Zobrazit plný text záznamu

Akademický článek

Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)

GPIHBP1, an endothelial cell (EC) protein, captures lipoprotein lipase (LPL) within the interstitial spaces (where it is secreted by myocytes and adipocytes) and transports it across ECs to its site of action in the capillary lumen. GPIHBP1’s 3-fin

Externí odkaz: https://doaj.org/article/4780a6e489eb4eb2947f3a57c5c18c7c

Zobrazit plný text záznamu

Akademický článek

Chylomicronemia from GPIHBP1 autoantibodies

Autor: Kazuya Miyashita, Jens Lutz, Lisa C. Hudgins, Dana Toib, Ambika P. Ashraf, Wenxin Song, Masami Murakami, Katsuyuki Nakajima, Michael Ploug, Loren G. Fong, Stephen G. Young, Anne P. Beigneux

Publikováno v: Journal of Lipid Research, Vol 61, Iss 11, Pp 1365-1376 (2020)

Some cases of chylomicronemia are caused by autoantibodies against glycosylphosphatidylinositol-anchored HDL binding protein 1 (GPIHBP1), an endothelial cell protein that shuttles LPL to the capillary lumen. GPIHBP1 autoantibodies prevent binding and

Externí odkaz: https://doaj.org/article/04b8654d456140aca80ec46a6659c392

Zobrazit plný text záznamu

Akademický článek

The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase

Autor: John G. Luz, Anne P. Beigneux, DeeAnn K. Asamoto, Cuiwen He, Wenxin Song, Christopher M. Allan, Jazmin Morales, Yiping Tu, Adam Kwok, Thomas Cottle, Muthuraman Meiyappan, Loren G. Fong, Judy E. Kim, Michael Ploug, Stephen G. Young, Gabriel Birrane

Publikováno v: Journal of Lipid Research, Vol 61, Iss 10, Pp 1347-1359 (2020)

For three decades, the LPL–specific monoclonal antibody 5D2 has been used to investigate LPL structure/function and intravascular lipolysis. 5D2 has been used to measure LPL levels, block the triglyceride hydrolase activity of LPL, and prevent the

Externí odkaz: https://doaj.org/article/a080c819825b4d84b63608de28505ec2

Zobrazit plný text záznamu

Akademický článek

An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner[S]

Autor: Christopher M. Allan, Patrick J. Heizer, Yiping Tu, Norma P. Sandoval, Rachel S. Jung, Jazmin E. Morales, Eniko Sajti, Ty D. Troutman, Thomas L. Saunders, Darren A. Cusanovich, Anne P. Beigneux, Casey E. Romanoski, Loren G. Fong, Stephen G. Young

Publikováno v: Journal of Lipid Research, Vol 60, Iss 4, Pp 869-879 (2019)

Glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1 (GPIHBP1), the protein that shuttles LPL to the capillary lumen, is essential for plasma triglyceride metabolism. When GPIHBP1 is absent, LPL remains stranded within t

Externí odkaz: https://doaj.org/article/24c19b72c23b4571b22124accec34bdf

Zobrazit plný text záznamu

Akademický článek

Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure

Autor: Mikael Larsson, Christopher M. Allan, Patrick J. Heizer, Yiping Tu, Norma P. Sandoval, Rachel S. Jung, Rosemary L. Walzem, Anne P. Beigneux, Stephen G. Young, Loren G. Fong

Publikováno v: Journal of Lipid Research, Vol 59, Iss 4, Pp 706-713 (2018)

Glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1 (GPIHBP1), an endothelial cell protein, binds LPL in the subendothelial spaces and transports it to the capillary lumen. In Gpihbp1−/− mice, LPL remains stranded i

Externí odkaz: https://doaj.org/article/569656b46a0e4a599c457cb73d1d2ee4

Zobrazit plný text záznamu

Akademický článek

Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL[S]

Autor: Mikael Larsson, Christopher M. Allan, Rachel S. Jung, Patrick J. Heizer, Anne P. Beigneux, Stephen G. Young, Loren G. Fong

Publikováno v: Journal of Lipid Research, Vol 58, Iss 9, Pp 1893-1902 (2017)

ApoC-III is often assumed to retard the intravascular processing of triglyceride-rich lipoproteins (TRLs) by inhibiting LPL, but that view is based largely on studies of free LPL. We now recognize that intravascular LPL is neither free nor loosely bo

Externí odkaz: https://doaj.org/article/da10f122d15a40adafea921b2e4f8132

Zobrazit plný text záznamu

Akademický článek

Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding

Autor: Christopher M. Allan, Cris J. Jung, Mikael Larsson, Patrick J. Heizer, Yiping Tu, Norma P. Sandoval, Tiffany Ly P. Dang, Rachel S. Jung, Anne P. Beigneux, Pieter J. de Jong, Loren G. Fong, Stephen G. Young

Publikováno v: Journal of Lipid Research, Vol 58, Iss 7, Pp 1453-1461 (2017)

Mutation of conserved cysteines in proteins of the Ly6 family cause human disease—chylomicronemia in the case of glycosylphosphatidylinositol-anchored HDL binding protein 1 (GPIHBP1) and paroxysmal nocturnal hemoglobinuria in the case of CD59. A mu

Externí odkaz: https://doaj.org/article/a2e86bfa1c6e411aac0c3ca83c2b4f34

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání