Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Anne Op de beeck"'
Autor:
Maikel L. Colli, Jessica L.E. Hill, Laura Marroquí, Jessica Chaffey, Reinaldo S. Dos Santos, Pia Leete, Alexandra Coomans de Brachène, Flavia M.M. Paula, Anne Op de Beeck, Angela Castela, Lorella Marselli, Lars Krogvold, Knut Dahl-Jorgensen, Piero Marchetti, Noel G. Morgan, Sarah J. Richardson, Décio L. Eizirik
Publikováno v:
EBioMedicine, Vol 36, Iss , Pp 367-375 (2018)
Background: Antibodies targeting PD-1 and its ligand PDL1 are used in cancer immunotherapy but may lead to autoimmune diseases, including type 1 diabetes (T1D). It remains unclear whether PDL1 is expressed in pancreatic islets of people with T1D and
Externí odkaz:
https://doaj.org/article/d2c64acf75394175ae0f41916579e6da
Autor:
Laura Marroqui, Miguel Lopes, Reinaldo S dos Santos, Fabio A Grieco, Merja Roivainen, Sarah J Richardson, Noel G Morgan, Anne Op de beeck, Decio L Eizirik
Publikováno v:
eLife, Vol 4 (2015)
Type 1 diabetes (T1D) is an autoimmune disease caused by loss of pancreatic β cells via apoptosis while neighboring α cells are preserved. Viral infections by coxsackieviruses (CVB) may contribute to trigger autoimmunity in T1D. Cellular permissive
Externí odkaz:
https://doaj.org/article/6614f4cf216b4fbd8648d890b4621aae
Autor:
Maikel L Colli, Tatiane C Nogueira, Florent Allagnat, Daniel A Cunha, Esteban N Gurzov, Alessandra K Cardozo, Merja Roivainen, Anne Op de Beeck, Decio L Eizirik
Publikováno v:
PLoS Pathogens, Vol 7, Iss 9, p e1002267 (2011)
The rise in type 1 diabetes (T1D) incidence in recent decades is probably related to modifications in environmental factors. Viruses are among the putative environmental triggers of T1D. The mechanisms regulating beta cell responses to viruses, howev
Externí odkaz:
https://doaj.org/article/01163dd383094d78971f37957700a520
Autor:
Florian Szymczak, Maria Inês Alvelos, Sandra Marín-Cañas, Ângela Castela, Stéphane Demine, Maikel Luis Colli, Anne Op de Beeck, Sofia Thomaidou, Lorella Marselli, Arnaud Zaldumbide, Piero Marchetti, Décio L. Eizirik
Publikováno v:
Science advances.
IFNα is a key regulator of the dialogue between pancreatic β cells and the immune system in early type 1 diabetes (T1D). IFNα up-regulates HLA class I expression in human β cells, fostering autoantigen presentation to the immune system. We observ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1937f3936f46cb2509af0ffef887b3
Autor:
Raghavendra G. Mirmira, Piero Marchetti, Wenyan Miao, Anne Op De Beeck, Lorella Marselli, Decio L. Eizirik, Craig Masse, Carmella Evans-Molina, Silvana Leit, Angela Castela, Alexandra Coomans de Brachène
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11f6f5b055279c0d9b90e054ff7e4e64
https://doi.org/10.1111/dom.14104/v2/response1
https://doi.org/10.1111/dom.14104/v2/response1
Autor:
Anne Op De Beeck, Jessica L. E. Hill, Sarah J. Richardson, Reinaldo Sousa Dos Santos, Piero Marchetti, Flavia M.M. Paula, Maikel Luis Colli, Lorella Marselli, Noel G. Morgan, Laura Marroquí, Decio L. Eizirik, Alexandra Coomans de Brachène
Publikováno v:
SSRN Electronic Journal.
Antibodies targeting PD-1 and its ligand PDL1 are used in cancer immunotherapy but may lead to autoimmune diseases, including type 1 diabetes (T1D). PD-1/PDL1 expression is probably important for maintaining tolerance, but it remains unclear whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac1936fb8cd8f9f2f1add9b9752950f5
https://doi.org/10.2139/ssrn.3188385
https://doi.org/10.2139/ssrn.3188385
Autor:
Anne Op De Beeck, Sarah J. Richardson, Piero Marchetti, Lorella Marselli, Decio L. Eizirik, Pia Leete, Maikel Luis Colli, Knut Dahl-Jørgensen, Reinaldo Sousa Dos Santos, Alexandra Coomans de Brachène, Lars Krogvold, Jessica R. Chaffey, Noel G. Morgan, Flavia M.M. Paula, Angela Castela, Jessica L. E. Hill, Laura Marroquí
Publikováno v:
EBioMedicine
EBioMedicine, 36
EBioMedicine, 36
Antibodies targeting PD-1 and its ligand PDL1 are used in cancer immunotherapy but may lead to autoimmune diseases, including type 1 diabetes (T1D). It remains unclear whether PDL1 is expressed in pancreatic islets of people with T1D and how is it re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532b503e1c6269c32493d5a32cecb8cc
Autor:
Decio L. Eizirik, Anne Op De Beeck
Publikováno v:
Trends in endocrinology and metabolism: TEM. 29(3)
Enteroviruses are important environmental contributors to islet inflammation (insulitis) in type 1 diabetes mellitus (T1DM). A recent study characterized the proteomic alterations induced by Coxsackievirus type B (CVB) infection of human islets. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35955129d4c20237eb7c0d62f386a183
https://pubmed.ncbi.nlm.nih.gov/29326001
https://pubmed.ncbi.nlm.nih.gov/29326001
Autor:
Fabio Arturo Grieco, Flemming Pociot, Piero Marchetti, Lorella Marselli, Izortze Santin, Laura Marroquí, Reinaldo Sousa Dos Santos, Anne Op De Beeck, Decio L. Eizirik, Tina Fløyel
Publikováno v:
Diabetes. 64:3808-3817
Pancreatic β-cells are destroyed by an autoimmune attack in type 1 diabetes. Linkage and genome-wide association studies point to >50 loci that are associated with the disease in the human genome. Pathway analysis of candidate genes expressed in hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60559c0f5ac8aa228db71c6dd56d5708
https://doi.org/10.2337/db15-0362
https://doi.org/10.2337/db15-0362
Autor:
Lorella Marselli, Decio L. Eizirik, Reinaldo Sousa Dos Santos, Piero Marchetti, Laura Marroquí, Anne Op De Beeck, Alexandra Coomans de Brachène
Publikováno v:
Diabetologia
Diabetologia, 60 (4
Diabetologia, 60 (4
Aims/hypothesis: Three hallmarks of the pancreatic islets in early human type 1 diabetes are overexpression of HLA class I, endoplasmic reticulum (ER) stress and beta cell apoptosis. The mediators of these phenomena remain to be defined. The type I i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a235641df9a8529e464d59133f218d1