Výsledky vyhledávání - "Anne O. Watts"

Identification and profiling of CXCR3-CXCR4 chemokine receptor heteromer complexes

Autor: Werner C. Jaeger, Rob Leurs, Ruth M. Seeber, Martine J. Smit, Hendrikus Boddeke, M. M. H van Lipzig, Jonathan Vinet, Anne O. Watts, Kevin D. G. Pfleger, M. van Zwam, M. M. C van der Lee, Henry F. Vischer, G.J.R. Zaman, Marco Siderius

Publikováno v: British Journal of Pharmacology. 168:1662-1674

BACKGROUND AND PURPOSE The C-X-C chemokine receptors 3 (CXCR3) and C-X-C chemokine receptors 4 (CXCR4) are involved in various autoimmune diseases and cancers. Small antagonists have previously been shown to cross-inhibit chemokine binding to CXCR4,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bda692355ccd7dfa6c86ee95a0e722cb
https://doi.org/10.1111/bph.12064

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Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR

Autor: Hendrikus Boddeke, Nieske Brouwer, Michiel R. Fokkens, Michel Meijer, Anne O. Watts, Jonathan Vinet, Dennis Verzijl, I. M. Dijkstra, van Hilmar Weering, Martine J. Smit, Vishnu Kannan, M. van Zwam, Rob Leurs, Henry F. Vischer, Knut Biber

Publikováno v: British Journal of Pharmacology. 168:1375-1387

Background and Purpose Induction of cellular migration is the primary effect of chemokine receptor activation. However, several chemokine receptor-like proteins bind chemokines without subsequent induction of intracellular signalling and chemotaxis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9970035fa6373644e1b654218e70707
https://doi.org/10.1111/bph.12042

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G protein‐coupled receptors: walking hand‐in‐hand, talking hand‐in‐hand?

Autor: Anne O. Watts, Saskia Nijmeijer, Rob Leurs, Henry F. Vischer

Publikováno v: Vischer, H F, Watts, A O, Nijmeijer, S & Leurs, R 2011, ' G-protein-coupled receptors: walking hand-in-hand, talking hand-in-hand? ', British Journal of Pharmacology, pp. 163-246 . https://doi.org/10.1111/j.1476-5381.2011.01229.x
British Journal of Pharmacology, 163-246. Wiley-Blackwell
STARTPAGE=163;ENDPAGE=246;ISSN=0007-1188;TITLE=British Journal of Pharmacology

Most cells express a panel of different G protein-coupled receptors (GPCRs) allowing them to respond to at least a corresponding variety of extracellular ligands. In order to come to an integrative well-balanced functional response these ligand-recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0fc204a3fda98864d73b49beea68cfe
https://doi.org/10.1111/j.1476-5381.2011.01229.x

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Chemokine cooperativity is caused by competitive glycosaminoglycan binding

Autor: Johan van der Vlag, Tracy M. Handel, Miranda M. C. van der Lee, Martine J. Smit, Joshua J. Ziarek, Guido J.R. Zaman, Henry F. Vischer, David C. Aguilar, Folkert Verkaar, Anne O. Watts, Jody van Offenbeek, Brian F. Volkman, Angelique L.W.M.M. Rops, Lambertus H. C. J. van Lith, Amanda E. I. Proudfoot

Publikováno v: Journal of Immunology. American Association of Immunologists
Verkaar, F, van Offenbeek, J, van der Lee, M M, Lith, L H, Watts, A O, Rops, A L, Aguilar, D C, Ziarek, J J, van der Vlag, J, Handel, T M, Volkman, B F, Proudfoot, A E, Vischer, H F, Zaman, G J & Smit, M J 2014, ' Chemokine cooperativity is caused by competitive glycosaminoglycan binding. ', Journal of Immunology . https://doi.org/10.4049/jimmunol.1302159
Journal of Immunology, 192, 3908-14
Journal of Immunology, 192, 8, pp. 3908-14

Chemokines comprise a family of secreted proteins that activate G protein-coupled chemokine receptors and thereby control the migration of leukocytes during inflammation or immune surveillance. The positional information required for such migratory b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d1df94c599bdc4c2980cf6001a99e2
https://research.vu.nl/en/publications/f10e7b35-6797-4ab4-a77d-bb082ef3ad0c

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β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR

Autor: Claudia A. W. Timmerman, Martine J. Smit, Martien Kuijer, Jody van Offenbeek, Folkert Verkaar, Lambertus H. C. J. van Lith, Anne O. Watts, Guido J.R. Zaman, Henry F. Vischer, Miranda M. C. van der Lee, Rob Leurs

Publikováno v: Watts, A O, Verkaar, F, van der Lee, M M C, Timmerman, C A W, Kuijer, M, van Offenbeek, J, van Lith, L H J C, Smit, M J, Leurs, R, Zaman, G J R & Vischer, H F 2013, ' β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR ', Journal of Biological Chemistry, vol. 288, no. 10, pp. 7169-7181 . https://doi.org/10.1074/jbc.M112.406108
Journal of Biological Chemistry, 288(10), 7169-7181. American Society for Biochemistry and Molecular Biology Inc.

Chemokine receptors form a large subfamily of G protein-coupled receptors that predominantly activate heterotrimeric Gi proteins and are involved in immune cell migration. CCX-CKR is an atypical chemokine receptor with high affinity for CCL19, CCL21,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355690808a39bb9f8637a779dd43195d
https://hdl.handle.net/1871.1/d2ad5443-82eb-4ccd-98c4-e60875664cce

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Label-free impedance responses of endogenous and synthetic chemokine receptor CXCR3 agonists correlate with G(i)-protein pathway activation

Autor: Laura H. Heitman, Anne O. Watts, Henry F. Vischer, Rob Leurs, Danny J. Scholten

Publikováno v: Watts, A O, Scholten, D J, Heitman, L H, Vischer, H F & Leurs, R 2012, ' Label-free impedance responses of endogenous and synthetic chemokine receptor CXCR3 agonists correlate with G(i)-protein pathway activation ', Biochemical and Biophysical Research Communications, vol. 419, pp. 412-418 . https://doi.org/10.1016/j.bbrc.2012.02.036
Biochemical and Biophysical Research Communications, 419, 412-418. Academic Press Inc.

The chemokine receptor CXCR3 is a G-protein-coupled receptor that signals through the Gα(i) class of heterotrimeric G-proteins. CXCR3 is highly expressed on activated T cells and has been proposed to be a therapeutic target in autoimmune disease. CX

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2660bd489090921b66f13f7452429b47
https://research.vu.nl/en/publications/a75132b4-b178-4d1a-b8b6-861508c81bf6

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