Lack of topoisomerase copy number changes in patients with de novo and relapsed diffuse large B-cell lymphoma

Autor: Peter Nørgaard, Michael Pedersen, Anne F. Lauritzen, Estrid Høgdall, Anne O. Gang, Peter de Nully Brown, Helle Charlotte Knudsen, Mette Ø. Pedersen, Signe Ledou Nielsen, Tim Svenstrup Poulsen

Publikováno v: Experimental Hematology. 43:534-536

Topoisomerase (TOP) gene copy number changes may predict response to treatment with TOP-targeting drugs in cancer treatment. This was first described in patients with breast cancer and is currently being investigated in other malignant diseases. TOP-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76532c2fb5c6b313eee8bddc0c6f2353
https://doi.org/10.1016/j.exphem.2015.04.006

A clinically based prognostic index for diffuse large B-cell lymphoma with a cut-off at 70 years of age significantly improves prognostic stratification:population-based analysis from the Danish Lymphoma Registry

Autor: Michael Pedersen, Michael Boe Møller, Hans Torben Mourits-Andersen, Anne O. Gang, Peter N. Brown, Bo Amdi Jensen, Francesco d'Amore, Paw Jensen, Tobias Wirenfeldt Klausen, Lars Møller Pedersen, Robert Smith Pedersen

Publikováno v: Gang, A O, Pedersen, M, d'Amore, F, Pedersen, L M, Jensen, B A, Jensen, P, Møller, M B, Mourits-Andersen, H T, Pedersen, R S, Klausen, T W & de N Brown, P 2015, ' A clinically based prognostic index for diffuse large B-cell lymphoma with a cut-off at 70 years of age significantly improves prognostic stratification : population-based analysis from the Danish Lymphoma Registry ', Leukemia and Lymphoma, vol. 56, no. 9, pp. 2556-2562 . https://doi.org/10.3109/10428194.2015.1010078
Gang, A O, Pedersen, M, d'Amore, F, Pedersen, L M, Jensen, B A, Jensen, P, Moller, M B, Mourits-Andersen, H T, Pedersen, R S, Klausen, T W & De, N B P 2015, ' A clinically based prognostic index for diffuse large B-cell lymphoma with a cut-off at 70 years of age significantly improves prognostic stratification : Population-based analysis from the Danish Lymphoma Registry ', Leukemia and Lymphoma, vol. 56, no. 9, pp. 2556-2562 . https://doi.org/10.3109/10428194.2015.1010078

The introduction of rituximab and generally improved health among elderly patients have increased the survival of patients with diffuse large B-cell lymphoma (DLBCL). The International Prognostic Index (IPI) from 1992 is based on pre-rituximab data f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53fe296ae55ebfc74e41b3dfbcd76e4
https://pure.au.dk/portal/da/publications/a-clinically-based-prognostic-index-for-diffuse-large-bcell-lymphoma-with-a-cutoff-at-70-years-of-age-significantly-improves-prognostic-stratification(81189750-9f11-47ed-b80d-ff3d5d508d6d).html

Cell of origin predicts outcome to treatment with etoposide-containing chemotherapy in young patients with high-risk diffuse large B-cell lymphoma

Autor: Michael Pedersen, Peter Nørgaard, Anne O. Gang, Tobias Wirenfeldt Klausen, Peter de Nully Brown, Mette Ø. Pedersen, Helle Charlotte Knudsen, Anne F. Lauritzen, Estrid Høgdall, Signe Ledou Nielsen

Publikováno v: Leukemialymphoma. 56(7)

Addition of etoposide to the R-CHOP chemotherapy regimen with cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab (R-CHOEP) has resulted in improved survival in young patients with high-risk diffuse large B-cell lymphoma (DLBCL). It

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c103cf88a0b03de840402a118304603
https://pubmed.ncbi.nlm.nih.gov/25379621

Genetic variants in the P2RX7gene are associated with risk of multiple myeloma

Autor: Henrik Gregersen, Morten Orebo Holmström, Niels Frost Andersen, Niklas Rye Jørgensen, Tobias Wirenfeldt Klausen, Peter Schwarz, Ulla Vogel, Niels Abildgaard, Peter Gimsing, Anne O. Gang, Annette Juul Vangsted

Publikováno v: Vangsted, A, Klausen, T, Gimsing, P, Abildgaard, N, Andersen, N F, Gang, A O, Holmström, M, Gregersen, H, Vogel, U, Schwarz, P & Jørgensen, N R 2014, ' Genetic variants in the P2RX7gene are associated with risk of multiple myeloma ', European Journal of Haematology, vol. 93, no. 2, pp. 172-174 . https://doi.org/10.1111/ejh.12353
Vangsted, A J, Klausen, T W, Gimsing, P, Abildgaard, N, Andersen, N F, Gang, A O, Holmström, M, Gregersen, H, Vogel, U, Schwarz, P & Jørgensen, N R 2014, ' Genetic variants in the P2RX7 gene are associated with risk of multiple myeloma ', European Journal of Haematology, vol. 93, no. 2, pp. 172-174 . https://doi.org/10.1111/ejh.12353

The P2 purinoreceptors are proteins that have nucleotides as their natural ligands. The P2RX7 receptor is involved in immune function bone remodelling and stimulation of the receptor induces apoptosis in myeloma cells (1;2). In a population-based stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca694def4d1a54f4a0824e169aa76ce
https://vbn.aau.dk/da/publications/7e32be2b-1ed4-4653-aafc-b1cca1b80f72

Double-hit BCL2/MYC translocations in a consecutive cohort of patients with large B-cell lymphoma - a single centre's experience

Autor: Tim Svenstrup Poulsen, Anne O. Gang, Helle Charlotte Knudsen, Anne F. Lauritzen, Peter Nørgaard, Mette Ø. Pedersen, Uffe O. Gang, Signe Ledou Nielsen

Publikováno v: European journal of haematology. 89(1)

Concurrent BCL2 and MYC translocations, so called double hit (DH), are a rare finding in large B-cell lymphoma (LBCL). Based on data from retrospective series, DH has been correlated with aggressive clinical behaviour and poor outcome. We conducted a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a391fce0a37d4629ad4f7bcab2c85a1e
https://pubmed.ncbi.nlm.nih.gov/22510149