Výsledky vyhledávání - "Anne Neuenfeldt"

An inhibitory C-terminal region dictates the specificity of A-adding enzymes

Autor: Mario Mörl, Sandy Tretbar, Anne Neuenfeldt, Heike Betat

Publikováno v: Proceedings of the National Academy of Sciences. 108:21040-21045

For efficient aminoacylation, tRNAs carry the conserved 3′-terminal sequence C-C-A, which is synthesized by highly specific tRNA nucleotidyltransferases (CCA-adding enzymes). In several prokaryotes, this function is accomplished by separate enzymes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b154707be0fbde3dedc5ef90fd63a995
https://doi.org/10.1073/pnas.1116117108

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Thermodynamic properties distinguish human mitochondrial aspartyl-tRNA synthetase from bacterial homolog with same 3D architecture

Autor: Eric Ennifar, Anne Neuenfeldt, Agnès Gaudry, Marie Sissler, Claude Sauter, Catherine Florentz, Bernard Lorber

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2013, 41 (4), pp.2698-2708. ⟨10.1093/nar/gks1322⟩

International audience; In the mammalian mitochondrial translation apparatus, the proteins and their partner RNAs are coded by two genomes. The proteins are nuclear-encoded and resemble their homologs, whereas the RNAs coming from the rapidly evolvin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8517ea6125ead3f83c89eba4fccc8a31
https://hal.archives-ouvertes.fr/hal-03366337

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Re-designed N-terminus enhances expression, solubility and crystallizability of mitochondrial protein

Autor: Claude Sauter, Bernard Lorber, Anne Neuenfeldt, Marie Sissler, Agnès Gaudry, Catherine Florentz

Publikováno v: Protein Engineering, Design and Selection
Protein Engineering, Design and Selection, Oxford University Press (OUP), 2012, 25 (9), pp.473-481. ⟨10.1093/protein/gzs046⟩

International audience; Mitochondrial aminoacyl-tRNA synthetases are key enzymes in translation. They are encoded by the nuclear genome, synthesized as precursors in the cytosol and imported. Most are matured by cleavage of their N-terminal targeting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffc24d9d1e0e46412f43e54cff300d6
https://pubmed.ncbi.nlm.nih.gov/22871419

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Evolution of tRNA nucleotidyltransferases: a small deletion generated CC-adding enzymes

Autor: Andrea Just, Heike Betat, Mario Mörl, Anne Neuenfeldt

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 105(23)

CCA-adding enzymes are specialized polymerases that add a specific sequence (C-C-A) to tRNA 3′ ends without requiring a nucleic acid template. In some organisms, CCA synthesis is accomplished by the collaboration of evolutionary closely related enz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a47ffa4bca30f86f21e8781f78345c
https://pubmed.ncbi.nlm.nih.gov/18523015

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