Did Homocysteine Take Part in the Start of the Synthesis of Peptides on the Early Earth?

Autor: Sparta Youssef-Saliba, Anne Milet, Yannick Vallée

Publikováno v: Biomolecules, Vol 12, Iss 4, p 555 (2022)

Unlike its shorter analog, cysteine, and its methylated derivative, methionine, homocysteine is not today a proteinogenic amino acid. However, this thiol containing amino acid is capable of forming an activated species intramolecularly. Its thiolacto

Externí odkaz: https://doaj.org/article/7370da1bb08e4ddba2a13bb13dd3fc13

The Reaction of Aminonitriles with Aminothiols: A Way to Thiol-Containing Peptides and Nitrogen Heterocycles in the Primitive Earth Ocean

Autor: Ibrahim Shalayel, Seydou Coulibaly, Kieu Dung Ly, Anne Milet, Yannick Vallée

Publikováno v: Life, Vol 8, Iss 4, p 47 (2018)

The Strecker reaction of aldehydes with ammonia and hydrogen cyanide first leads to α-aminonitriles, which are then hydrolyzed to α-amino acids. However, before reacting with water, these aminonitriles can be trapped by aminothiols, such as cystein

Externí odkaz: https://doaj.org/article/cf2a63ca4fbb4c3396dda965a5041072

DFT and TDDFT Study of 4-((Furan-2-Ylmethyl)Sulfonyl)-Substituted ZINC(II) Phthalocyanine: Importance of Grimme Dispersion with A Becke–Johnson Damping Correction and the Substituent Effect

Autor: M. Khazri, K. Sahra, S. Messaoudi, B. Jamoussi, Anne Milet

Publikováno v: Journal of Structural Chemistry. 61:844-851

In this work, we report a theoretical study on the structural, vibrational, and electronic properties of 4-((furan-2-ylmethyl)sulfonyl)-substituted zinc(II) phthalocyanine. We start to study the performance of DFT functionals for the unsubstituted sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc16639d5bac95fd4f0e0e257f3c0deb
https://doi.org/10.1134/s0022476620060025

Ion Pairing in HCl–Water Clusters: From Electronic Structure Investigations to Multiconfigurational Force-Field Development

Autor: Rolf David, Revati Kumar, Anne Milet, Caitlin G. Bresnahan

Publikováno v: The Journal of Physical Chemistry A. 123:9371-9381

In the bulk, condensed-phase HCl exists as a dissociated Cl- ion and a proton that is delocalized over solvating water molecules. However, in the gas phase, HCl is covalent, and even on the introduction of hydrating water molecules, the HCl covalent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c38b4c4077ec38d6b958f71a51e904
https://doi.org/10.1021/acs.jpca.9b07775

A way to thioacetate esters compatible with non-oxidative prebiotic conditions

Autor: Yannick Vallée, Naoual Leqraa, Yvain Nicolet, Anne Milet

Publikováno v: Scientific Reports
Scientific Reports, 2020, 10 (1), pp.14488. ⟨10.1038/s41598-020-71524-7⟩
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.14488. ⟨10.1038/s41598-020-71524-7⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)

The centrality of pyruvate oxidative decarboxylation into acetyl-CoA in current biochemistry is a strong argument for proposing that a similar reaction have been necessary for the development of an effective protometabolism on the primitive Earth. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b04de7cff680998e00d8d007e46a79
https://hal.univ-grenoble-alpes.fr/hal-02934448