Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Anne Mette G. Jensen"'
Autor:
Giulia Monti, Mads Kjolby, Anne Mette G. Jensen, Mariet Allen, Juliane Reiche, Peter L. Møller, Raquel Comaposada-Baró, Bartlomiej E. Zolkowski, Cármen Vieira, Margarita Melnikova Jørgensen, Ida E. Holm, Paul N. Valdmanis, Niels Wellner, Christian B. Vægter, Sarah J. Lincoln, Anders Nykjær, Nilüfer Ertekin-Taner, Jessica E. Young, Mette Nyegaard, Olav M. Andersen
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract SORL1 is strongly associated with both sporadic and familial forms of Alzheimer’s disease (AD), but a lack of information about alternatively spliced transcripts currently limits our understanding of the role of SORL1 in AD. Here, we descr
Externí odkaz:
https://doaj.org/article/6593f8c6612a4dd48b7424bbb99fda5f
Autor:
Olav M. Andersen, Giulia Monti, Anne Mette G. Jensen, Matthijs de Waal, Marc Hulsman, Johan G. Olsen, Henne Holstege
SORL1encodes the retromer-associated receptor SORLA that functions in endosomal recycling. Rare variants inSORL1have been associated with Alzheimer’s disease (AD) and rare pathogenic variants are estimated to occur in up to 2.75% of early onset AD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e9fc8b6497ff8835ade4f6bd1b938dc
https://doi.org/10.1101/2023.02.27.524103
https://doi.org/10.1101/2023.02.27.524103
Autor:
Anne Mette G. Jensen, Yu Kitago, Elnaz Fazeli, Christian B. Vægter, Scott A. Small, Gregory A. Petsko, Olav M. Andersen
Publikováno v:
Jensen, A M G, Kitago, Y, Fazeli, E, Vægter, C B, Small, S A, Petsko, G A & Andersen, O M 2023, ' Dimerization of the Alzheimer's disease pathogenic receptor SORLA regulates its association with retromer ', Proceedings of the National Academy of Sciences, vol. 120, no. 4, e2212180120 . https://doi.org/10.1073/pnas.2212180120
SORL1 , the gene encoding the large multidomain SORLA protein, has emerged as only the fourth gene that when mutated can by itself cause Alzheimer’s disease (AD), and as a gene reliably linked to both the early- and late-onset forms of the disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789be2709cc6de06e9087452c46e1ba1
https://pure.au.dk/portal/da/publications/dimerization-of-the-alzheimers-disease-pathogenic-receptor-sorla-regulates-its-association-with-retromer(4cd16520-6b3c-4451-acc7-b0fd6b8859e4).html
https://pure.au.dk/portal/da/publications/dimerization-of-the-alzheimers-disease-pathogenic-receptor-sorla-regulates-its-association-with-retromer(4cd16520-6b3c-4451-acc7-b0fd6b8859e4).html
Autor:
Olav M. Andersen, Nikolaj Bøgh, Anne M. Landau, Gro G. Pløen, Anne Mette G. Jensen, Giulia Monti, Benedicte P. Ulhøi, Jens R. Nyengaard, Kirsten R. Jacobsen, Margarita M. Jørgensen, Ida E. Holm, Marianne L. Kristensen, Aage Kristian O. Alstrup, Esben S.S. Hansen, Charlotte E. Teunissen, Laura Breidenbach, Mathias Droescher, Ying Liu, Hanne S. Pedersen, Henrik Callesen, Yonglun Luo, Lars Bolund, David J. Brooks, Christoffer Laustsen, Scott A. Small, Lars F. Mikkelsen, Charlotte B. Sørensen
Publikováno v:
Andersen, O M, Bøgh, N, Landau, A M, Pløen, G G, Jensen, A M G, Monti, G, Ulhøi, B P, Nyengaard, J R, Jacobsen, K R, Jørgensen, M M, Holm, I E, Kristensen, M L, Alstrup, A K O, Hansen, E S S, Teunissen, C E, Breidenbach, L, Droescher, M, Liu, Y, Pedersen, H S, Callesen, H, Luo, Y, Bolund, L, Brooks, D J, Laustsen, C, Small, S A, Mikkelsen, L F & Sørensen, C B 2022, ' A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency ', Cell reports. Medicine, vol. 3, no. 9, 100740 . https://doi.org/10.1016/j.xcrm.2022.100740
Andersen, O M, Bøgh, N, Landau, A M, Pløen, G G, Jensen, A M G, Monti, G, Ulhøi, B P, Nyengaard, J R, Jacobsen, K R, Jørgensen, M M, Holm, I E, Kristensen, M L, Alstrup, A K O, Hansen, E S S, Teunissen, C E, Breidenbach, L, Droescher, M, Liu, Y, Pedersen, H S, Callesen, H, Luo, Y, Bolund, L, Brooks, D J, Laustsen, C, Small, S A, Mikkelsen, L F & Sørensen, C B 2022, ' A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency ', Cell Reports Medicine, vol. 3, no. 9, 100740 . https://doi.org/10.1016/j.xcrm.2022.100740
Cell Reports Medicine, 3(9):100740. Cell Press
Andersen, O M, Bøgh, N, Landau, A M, Pløen, G G, Jensen, A M G, Monti, G, Ulhøi, B P, Nyengaard, J R, Jacobsen, K R, Jørgensen, M M, Holm, I E, Kristensen, M L, Alstrup, A K O, Hansen, E S S, Teunissen, C E, Breidenbach, L, Droescher, M, Liu, Y, Pedersen, H S, Callesen, H, Luo, Y, Bolund, L, Brooks, D J, Laustsen, C, Small, S A, Mikkelsen, L F & Sørensen, C B 2022, ' A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency ', Cell Reports Medicine, vol. 3, no. 9, 100740 . https://doi.org/10.1016/j.xcrm.2022.100740
Cell Reports Medicine, 3(9):100740. Cell Press
The established causal genes in Alzheimer's disease (AD), APP, PSEN1, and PSEN2, are functionally characterized using biomarkers, capturing an in vivo profile reflecting the disease's initial preclinical phase. Mutations in SORL1, encoding the endoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692217e27d26c70f47e5caa412c77719
https://vbn.aau.dk/da/publications/871f36d7-57e4-414a-9919-50f1b6541ce5
https://vbn.aau.dk/da/publications/871f36d7-57e4-414a-9919-50f1b6541ce5
Autor:
Sarah Lincoln, Peter L. Møller, Juliane Reiche, Anne Mette G. Jensen, Margarita Melnikova Jørgensen, Bartlomiej E. Zolkowski, Niels Wellner, Mads Kjolby, Anders Nykjaer, Jessica E. Young, Ida E. Holm, Nilufer Ertekin-Taner, Giulia Monti, Mariet Allen, Christian Bjerggaard Vaegter, Olav M. Andersen, Raquel Comaposada-Baró, Paul N. Valdmanis, Cármen Vieira, Mette Nyegaard
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Acta Neuropathologica Communications
Monti, G, Kjolby, M, Jensen, A M G, Allen, M, Reiche, J, Møller, P L, Comaposada-Baró, R, Zolkowski, B E, Vieira, C, Jørgensen, M M, Holm, I E, Valdmanis, P N, Wellner, N, Vægter, C B, Lincoln, S J, Nykjær, A, Ertekin-Taner, N, Young, J E, Nyegaard, M & Andersen, O M 2021, ' Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer's disease ', Acta Neuropathologica Communications, vol. 9, 43 . https://doi.org/10.1186/s40478-021-01140-7
Acta Neuropathologica Communications
Monti, G, Kjolby, M, Jensen, A M G, Allen, M, Reiche, J, Møller, P L, Comaposada-Baró, R, Zolkowski, B E, Vieira, C, Jørgensen, M M, Holm, I E, Valdmanis, P N, Wellner, N, Vægter, C B, Lincoln, S J, Nykjær, A, Ertekin-Taner, N, Young, J E, Nyegaard, M & Andersen, O M 2021, ' Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer's disease ', Acta Neuropathologica Communications, vol. 9, 43 . https://doi.org/10.1186/s40478-021-01140-7
SORL1 is strongly associated with both sporadic and familial forms of Alzheimer’s disease (AD), but a lack of information about alternatively spliced transcripts currently limits our understanding of the role of SORL1 in AD. Here, we describe a SOR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ad653f92bf542e720982592384a034
https://doaj.org/article/6593f8c6612a4dd48b7424bbb99fda5f
https://doaj.org/article/6593f8c6612a4dd48b7424bbb99fda5f
Autor:
Christoffer Laustsen, Anne M. Landau, Margarita Melnikova Joergensen, Marianne Lundsgaard Kristensen, Olav M. Andersen, Ida Elisabeth Holm, Lars Friis Mikkelsen, Nikolaj Boegh, Mathias Droescher, Giulia Monti, Hanne Skovsgaard Pedersen, Lars Bolund, Henrik Callesen, Benedicte Parm Ulhoei, Charlotte Brandt Soerensen, Kirsten Rosenmay Jacobsen, Scott A. Small, Laura Breidenbach, Anne Mette G. Jensen, Jens R. Nyengaard, Gro Grunnet Ploeen, Esben Søvsø Szocska Hansen, David J. Brooks, Ying Liu, Charlotte E. Teunissen, Yonglun Luo
The few established causal genes in Alzheimer’s disease (AD), mutations in APP and PSENs, have been functionally characterized using biomarkers, capturing an in vivo profile reflecting the disease’s initial preclinical phase. SORL1, a gene encodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f87bb3d517054a38de8863ae1ace630b
https://doi.org/10.1101/2021.07.13.452149
https://doi.org/10.1101/2021.07.13.452149
Autor:
Giulia Monti, Lars Friis Mikkelsen, Marianne Lundsgaard Kristensen, Kirsten R Jacobsen, Charlotte E. Teunissen, David J. Brooks, Lars Bolund, Anne M. Landau, Christoffer Laustsen, Scott A. Small, Yonglun Luo, Anne Mette G. Jensen, Laura Breidenbach, Gro Grunnet Pløen, Jens R. Nyengaard, Margarita Melnikova Jørgensen, Hanne Skovsgaard Pedersen, Esben Søvsø Szocska Hansen, Charlotte S. Sørensen, Nikolaj Bøgh, Ying Liu, Mathias Droescher, Henrik Callesen, Benedicte Parm Ulhøi, Ida Elisabeth Holm, Olav M. Andersen
Publikováno v:
SSRN Electronic Journal.
The few established causal genes in Alzheimer’s disease (AD), mutations in APP and PSENs, have been functionally characterized using biomarkers, capturing an in vivo profile reflecting the disease’s initial preclinical phase. SORL1, a gene encodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c889777cc95690fcd8e7edfc98005a51
https://doi.org/10.2139/ssrn.3911555
https://doi.org/10.2139/ssrn.3911555