Involvement of TLR2–TLR4, NLRP3, and IL-17 in pain induced by a novel Sprague-Dawley rat model of experimental autoimmune encephalomyelitis

Autor: Andrew J. Kwilasz, Madison A. Clements, Tracey A. Larson, Kevin M. Harris, Scott T. Litwiler, Brodie J. Woodall, Laurel S. Todd, Anouk E. W. Schrama, Eric H. Mitten, Steven F. Maier, Anne-Marie Van Dam, Kenner C. Rice, Linda R. Watkins

Publikováno v: Frontiers in Pain Research, Vol 3 (2022)

Up to 92% of patients suffering from multiple sclerosis (MS) experience pain, most without adequate treatment, and many report pain long before motor symptoms associated with MS diagnosis. In the most commonly studied rodent model of MS, experimental

Externí odkaz: https://doaj.org/article/f69561aa0381439c90004b4abc048684

Toll-like Receptor 4 Is Upregulated in Parkinson’s Disease Patients and Co-Localizes with pSer129αSyn: A Possible Link with the Pathology

Autor: Carmela Conte, Angela Ingrassia, John Breve, John J. Bol, Evelien Timmermans-Huisman, Anne-Marie van Dam, Tommaso Beccari, Wilma D. J. van de Berg

Publikováno v: Cells, Vol 12, Iss 10, p 1368 (2023)

Growing evidence suggests a crucial role of neuroinflammation in the pathophysiology of Parkinson’s disease (PD). Neuroinflammation is linked to the accumulation and aggregation of a-synuclein (αSyn), the primary pathological hallmark of PD. Toll-

Externí odkaz: https://doaj.org/article/2f4bfa8a5ba84b5c88f41d35838df315

In vivo assessment of neuroinflammation in progressive multiple sclerosis: a proof of concept study with [18F]DPA714 PET

Autor: Marloes H. J. Hagens, Sandeep V. Golla, Martijn T. Wijburg, Maqsood Yaqub, Dennis Heijtel, Martijn D. Steenwijk, Patrick Schober, John J. P. Brevé, Robert C. Schuit, Tristan A. Reekie, Michael Kassiou, Anne-Marie van Dam, Albert D. Windhorst, Joep Killestein, Frederik Barkhof, Bart N. M. van Berckel, Adriaan A. Lammertsma

Publikováno v: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-10 (2018)

Abstract Background Over the past decades, positron emission tomography (PET) imaging has become an increasingly useful research modality in the field of multiple sclerosis (MS) research, as PET can visualise molecular processes, such as neuroinflamm

Externí odkaz: https://doaj.org/article/2093b350138a428a80c3cf2c7276144c

Tissue transglutaminase in astrocytes is enhanced by inflammatory mediators and is involved in the formation of fibronectin fibril-like structures

Autor: Nathaly Espitia Pinzón, John J. P. Brevé, John G. J. M. Bol, Benjamin Drukarch, Wia Baron, Anne-Marie van Dam

Publikováno v: Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-13 (2017)

Abstract Background During multiple sclerosis (MS) lesion formation, inflammatory mediators are produced by microglial cells and invading leukocytes. Subsequently, hypertrophic astrocytes fill the lesion and produce extracellular matrix (ECM) protein

Externí odkaz: https://doaj.org/article/5439e290a360424b93f60c75943997ea

Exploring reported genes of microglia RNA-sequencing data

Autor: Emma Gerrits, Inge Huitinga, Sara Palacin i Bonson, Anne-Marie van Dam, Thecla A. van Wageningen, Bart J. L. Eggen

Publikováno v: GLIA, 69, 2933-2946. John Wiley and Sons Inc.
van Wageningen, T A, Gerrits, E, Palacin i Bonson, S, Huitinga, I, Eggen, B J L & van Dam, A-M 2021, ' Exploring reported genes of microglia RNA-sequencing data: Uses and considerations ', GLIA, vol. 69, no. 12, pp. 2933-2946 . https://doi.org/10.1002/glia.24078
Glia, 69(12), 2933-2946. Wiley
GLIA, 69(12), 2933-2946. John Wiley and Sons Inc.

The advent of RNA-sequencing techniques has made it possible to generate large, unbiased gene expression datasets of tissues and cell types. Several studies describing gene expression data of microglia from Alzheimer's disease or multiple sclerosis h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c810c011843ba8a57f22961325434e7e
https://hdl.handle.net/11370/78c96de1-96f6-4d4b-b888-ce5472c8e463