Výsledky vyhledávání - "Anne Marie Sims"

The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis

Autor: B. Paul Wordsworth, Gordon W. Duff, Andrei Calin, Owen Beynon, Aaron Abbott, Anne Marie Sims, A. M. Crane, Linda A. Bradbury, Ibi Herzberg, Heather J. Cordell, Andrew E. Timms, Lon R. Cardon, Matthew A. Brown, Mark R.E. Coyne

Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy. Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone is not sufficient to explain the pattern of familial recurrence of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ea5a91180a015f6cc2d73742819a86
https://doi.org/10.1086/424695

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ADRB2 polymorphisms and budesonide/formoterol responses in COPD

Autor: William C. Bailey, Sarah R. Bujac, Ubaldo J. Martin, Eugene R. Bleecker, Deborah A. Meyers, Anne-Marie Sims, M. Goldman

Publikováno v: Chest. 142(2)

Background Effects of β 2 -adrenergic receptor gene ( ADRB2 ) polymorphism on therapeutic responses to long-acting β 2 -adrenergic agonists have not been evaluated in long-term COPD trials. We aimed to investigate the effects of the ADRB2 Gly16Arg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc376e6b011cb87eee0a8c05b2090d86
https://pubmed.ncbi.nlm.nih.gov/22383665

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Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns

Autor: Jennifer J, Pointon, Kay, Chapman, David, Harvey, Anne-Marie, Sims, Linda, Bradbury, Kari, Laiho, Markku, Kauppi, Kalevi, Kaarela, Jaakko, Tuomilehto, Matthew A, Brown, B Paul, Wordsworth

Publikováno v: The Journal of rheumatology. 35(8)

To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS).A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5da9e4bff3a51d5a2ea868240450a27c
https://pubmed.ncbi.nlm.nih.gov/18634146

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Dissection of class III major histocompatibility complex haplotypes associated with rheumatoid arthritis

Autor: Kirk A. Rockett, Andrew E. Timms, Anne Marie Sims, C. Darke, B. Paul Wordsworth, J Newton, Dominic P. Kwiatkowski, Sinead Harney, Matthew A. Brown

Publikováno v: Arthritis and rheumatism. 50(7)

Objective. We have previously identified a single-nucleotide polymorphism (SNP) haplotype involving the lymphotoxin alpha (LTA) and tumor necrosis factor (TNF) loci (termed haplotype LTA-TNF2) on chromosome 6 that shows differential association with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8061973f66fc6b94b6e9af466b2280fc
https://pubmed.ncbi.nlm.nih.gov/15248209

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Characterization of components of the mismatch repair machinery in Trypanosoma brucei

Autor: Joanna S, Bell, Timothy I, Harvey, Anne-Marie, Sims, Richard, McCulloch

Publikováno v: Molecular microbiology. 51(1)

Mismatch repair is one of a number of DNA repair pathways that cells possess to deal with damage to their genome. Mismatch repair is concerned with the recognition and correction of incorrectly paired bases, which can be base-base mismatches or inser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::900951b8310d05094c88fb11aac28ac3
https://pubmed.ncbi.nlm.nih.gov/14651619

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