Prolonged insulin-induced hypoglycaemia reduces ß-cell activity rather than number in pancreatic islets in non-diabetic rats

Autor: Vivi F. H. Jensen, Anne-Marie Mølck, Jette Nowak, Johannes J. Fels, Jens Lykkesfeldt, Ingrid B. Bøgh

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Abstract Pancreatic β-cells have an extraordinary ability to adapt to acute fluctuations in glucose levels by rapid changing insulin production to meet metabolic needs. Although acute changes have been characterised, effects of prolonged metabolic s

Externí odkaz: https://doaj.org/article/e3de2ad81ff644939436faa21a79b44b

Chronic Hyperinsulinaemic Hypoglycaemia in Rats Is Accompanied by Increased Body Weight, Hyperleptinaemia, and Decreased Neuronal Glucose Transporter Levels in the Brain

Autor: Vivi F. H. Jensen, Anne-Marie Mølck, Melissa Chapman, Lene Alifrangis, Lene Andersen, Jens Lykkesfeldt, Ingrid B. Bøgh

Publikováno v: International Journal of Endocrinology, Vol 2017 (2017)

The brain is vulnerable to hypoglycaemia due to a continuous need of energy substrates to meet its high metabolic demands. Studies have shown that severe acute insulin-induced hypoglycaemia results in oxidative stress in the rat brain, when neuroglyc

Externí odkaz: https://doaj.org/article/e70575f29fa044dc8a5932cf5841bac9

Evaluation of Cell Proliferation in Rat Mammary Glands Is Not Predictive of the Carcinogenic Potential of Insulin In Vivo

Autor: Anne-Marie Mølck, Ingrid Sjögren, Jette Nowak, Vivi F. H. Jensen, Inger Thorup, Peter R. Brinck

Publikováno v: International Journal of Toxicology. 39:560-576

For nonclinical safety-assessment of insulin analogues in vivo, mitogenic effects are compared to that of human insulin. Besides histopathologic evaluation, this usually includes assessment of cell proliferation (CP) in mammary glands. Insulin analog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a354a664c636addf55ba41b1319f3c0
https://doi.org/10.1177/1091581820941776

Inner histopathologic changes and disproportionate zone volumes in foetal growth plates following gestational hypoglycaemia in rats

Autor: Louise Pedersen, Jette Nowak, Pernille Tveden-Nyborg, Anne Marie Mølck, Birgitte M. Viuff, Jens Lykkesfeldt, Vivi F. H. Jensen, Suzi H. Madsen, Kristina Åkesson, Johannes Josef Fels, Ingrid Brück Bøgh, Fiona E. McGuigan, Charlotte Lund Rasmussen

Publikováno v: Scientific Reports
Jensen, V F H, Mølck, A-M, Bøgh, I B, Nowak, J, Viuff, B M, Rasmussen, C L M, Pedersen, L, Fels, J J, Madsen, S H, McGuigan, F E, Tveden-Nyborg, P, Lykkesfeldt, J & Akesson, K E 2020, ' Inner histopathologic changes and disproportionate zone volumes in foetal growth plates following gestational hypoglycaemia in rats ', Scientific Reports, vol. 10, no. 1, 5609 . https://doi.org/10.1038/s41598-020-62554-2
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)

Maternal hypoglycaemia throughout gestation until gestation day (GD)20 delays foetal growth and skeletal development. While partially prevented by return to normoglycaemia after completed organogenesis (GD17), underlying mechanisms are not fully unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05d0a741441758b801d4c3c944bb825
https://doi.org/10.1038/s41598-020-62554-2

Proximal Neuropathy and Associated Skeletal Muscle Changes Resembling Denervation Atrophy in Hindlimbs of Chronic Hypoglycaemic Rats

Autor: Anne-Marie Mølck, Vivi F. H. Jensen, Jette Nowak, Ingrid Brück Bøgh, Henrik Søeborg, Melissa Chapman, Jens Lykkesfeldt

Publikováno v: Basic & Clinical Pharmacology & Toxicology. 122:165-175

Peripheral neuropathy is one of the most common complications of diabetic hyperglycaemia. Insulin-induced hypoglycaemia (IIH) might potentially exacerbate or contribute to neuropathy as hypoglycaemia also causes peripheral neuropathy. In rats, IIH in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f91c466e1c64d736cda93b36d501c87
https://doi.org/10.1111/bcpt.12870