Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Anne Marie Lefrançois-Martinez"'
Autor:
Damien Dufour, Typhanie Dumontet, Isabelle Sahut-Barnola, Aude Carusi, Méline Onzon, Eric Pussard, James Jr Wilmouth, Julie Olabe, Cécily Lucas, Adrien Levasseur, Christelle Damon-Soubeyrand, Jean-Christophe Pointud, Florence Roucher-Boulez, Igor Tauveron, Guillaume Bossis, Edward T. Yeh, David T. Breault, Pierre Val, Anne-Marie Lefrançois-Martinez, Antoine Martinez
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
SUMOylation is a mechanism of posttranslational modification involved in eukaryotic cell homeostasis. Here the authors report that mice unable to control SUMOylation in the adrenal cortex develop a selective defect in glucocorticoid production due to
Externí odkaz:
https://doaj.org/article/94675fdf0b57490d98010c427e95a3d3
Autor:
Coralie Drelon, Annabel Berthon, Isabelle Sahut-Barnola, Mickaël Mathieu, Typhanie Dumontet, Stéphanie Rodriguez, Marie Batisse-Lignier, Houda Tabbal, Igor Tauveron, Anne-Marie Lefrançois-Martinez, Jean-Christophe Pointud, Celso E. Gomez-Sanchez, Seppo Vainio, Jingdong Shan, Sonia Sacco, Andreas Schedl, Constantine A. Stratakis, Antoine Martinez, Pierre Val
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The adrenal cortex undergoes functional zonation to generate an outer zona glomerulosa (ZG) and inner zona fasciculata (ZF), but how this is regulated at a molecular level is unclear. Here, the authors show that ZG differentiation is stimulated by WN
Externí odkaz:
https://doaj.org/article/47e9d947aff442c7b85b4848141ee1ea
Autor:
James J. Wilmouth, Julie Olabe, Diana Garcia-Garcia, Cécily Lucas, Rachel Guiton, Florence Roucher-Boulez, Damien Dufour, Christelle Damon-Soubeyrand, Isabelle Sahut-Barnola, Jean-Christophe Pointud, Yoan Renaud, Adrien Levasseur, Igor Tauveron, Anne-Marie Lefrançois-Martinez, Antoine Martinez, Pierre Val
Publikováno v:
Science Advances
Science Advances, 2022, 8 (41), ⟨10.1126/sciadv.add0422⟩
Science Advances, 2022, 8 (41), ⟨10.1126/sciadv.add0422⟩
SummaryIn contrast with most cancers, adrenocortical carcinomas (ACC) are more frequent in women than men, but the underlying mechanisms of this sexual dimorphism remain elusive. Homozygous deletion of the negative WNT pathway regulator ZNRF3 is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa770a0a84d3d41c96cad1df1fd90a1
https://cnrs.hal.science/hal-03864625
https://cnrs.hal.science/hal-03864625
Autor:
Isabelle Sahut-Barnola, Anne-Marie Lefrançois-Martinez, Damien Dufour, Jean-Marie Botto, Crystal Kamilaris, Fabio R. Faucz, Constantine A. Stratakis, Pierre Val, Antoine Martinez
Publikováno v:
Journal of Investigative Dermatology
Journal of Investigative Dermatology, 2022, 142 (11), pp.2949-2957.e9. ⟨10.1016/j.jid.2022.04.019⟩
Journal of Investigative Dermatology, 2022, ⟨10.1016/j.jid.2022.04.019⟩
Journal of Investigative Dermatology, 2022, 142 (11), pp.2949-2957.e9. ⟨10.1016/j.jid.2022.04.019⟩
Journal of Investigative Dermatology, 2022, ⟨10.1016/j.jid.2022.04.019⟩
Carney complex (CNC) is a rare familial multi-neoplastic syndrome predisposing to endocrine and non-endocrine tumors due to inactivating mutations of PRKAR1A leading to perturbations of the cAMP protein kinase A (PKA) signaling pathway. Skin lesions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18308f2b0c45bb111d2bcd74af0683c
https://doi.org/10.1101/2022.01.26.477839
https://doi.org/10.1101/2022.01.26.477839
Autor:
Anne-Marie Lefrançois-Martinez, Amandine Septier, Amanda Swain, Jean-Christophe Pointud, Constantine A. Stratakis, Fabio R. Faucz, Florian Guillou, James Wilmouth, Antoine-Guy Lopez, Adrien Levasseur, Ingrid Plotton, Cyril Djari, Seppo Vainio, Crystal Kamilaris, Isabelle Sahut-Barnola, Hervé Lefebvre, Damien Dufour, Pierre Val, Nathanaëlle Montanier, Antoine Martinez, Igor Tauveron
Publikováno v:
The Journal of clinical investigation
The Journal of clinical investigation, 2021, 131 (23), ⟨10.1172/JCI146910⟩
J Clin Invest
The Journal of clinical investigation, 2021, 131 (23), pp.1-18. ⟨10.1172/JCI146910⟩
The Journal of clinical investigation, 2021, 131 (23), ⟨10.1172/JCI146910⟩
J Clin Invest
The Journal of clinical investigation, 2021, 131 (23), pp.1-18. ⟨10.1172/JCI146910⟩
International audience; Large-cell calcifying Sertoli cell tumors (LCCSCTs) are among the most frequent lesions occurring in male Carney complex (CNC) patients. Although they constitute a key diagnostic criterion for this rare multiple neoplasia synd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa42b91af6fe83aa0f6186699768eadc
https://hal.inrae.fr/hal-03462738
https://hal.inrae.fr/hal-03462738
Autor:
Cyril Djari, Iabelle Sahut-Barnola, Constantine Stratakis, Hervé Lefèbvre, Florian Guillou, Amanda Swain, Antoine Martinez, Anne-Marie Lefrançois-Martinez
Publikováno v:
Annales d'Endocrinologie. 83:457
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f9a182feae744a213a14450ffde7cac
https://doi.org/10.1016/j.ando.2022.09.012
https://doi.org/10.1016/j.ando.2022.09.012
Autor:
Bruno Ragazzon, Jean-Christophe Pointud, Houda Tabbal, Pierre Val, Igor Tauveron, Coralie Drelon, M. Batisse-Lignier, Cyril Djari, Stéphanie Rodriguez, Anne-Marie Lefrançois-Martinez, Amandine Septier, Jérôme Bertherat, Guillaume Assié, Isabelle Sahut-Barnola, Mickael Mathieu, Antoine Martinez
Publikováno v:
British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 2019, 121 (5), pp.384-394. ⟨10.1038/s41416-019-0538-y⟩
British Journal of Cancer, 2019, 121 (5), pp.384-394. ⟨10.1038/s41416-019-0538-y⟩
British Journal of Cancer, Cancer Research UK, 2019, 121 (5), pp.384-394. ⟨10.1038/s41416-019-0538-y⟩
British Journal of Cancer, 2019, 121 (5), pp.384-394. ⟨10.1038/s41416-019-0538-y⟩
International audience; BACKGROUND: EZH2 is overexpressed and associated with poor prognosis in adrenocortical carcinoma (ACC) and its inhibition reduces growth and aggressiveness of ACC cells in culture. Although EZH2 was identified as the methyltra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e8aeb4b82b5deb9b1796239f7afa18
https://doi.org/10.1038/s41416-019-0538-y
https://doi.org/10.1038/s41416-019-0538-y
Autor:
Gianni D Angelini, Antoine Martinez, Stafford L. Lightman, Anne-Marie Lefrançois-Martinez, Francesca Spiga, George Horn, Georgina G J Hazell, Daniel Fudulu
Publikováno v:
Fudulu, D P, Horn, G, Hazell, G G J & Angelini, G D & Lightman, S L & Spiga, F 2021, ' Co-culture of monocytes and zona fasciculata adrenal cells : An in vitro model to study the immune-adrenal cross-talk ', Molecular and Cellular Endocrinology, vol. 526, 111195 . https://doi.org/10.1016/j.mce.2021.111195
Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology
The hypothalamic-pituitary-adrenal axis is the primary neuroendocrine system activated to re-establish homeostasis during periods of stress, including critical illness and major surgery. During critical illness, evidence suggests that locally induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc3564720b410cdc31df285bbf296e4
https://research-information.bris.ac.uk/en/publications/263de9c3-1b27-4705-8a2a-17301ccff4b3
https://research-information.bris.ac.uk/en/publications/263de9c3-1b27-4705-8a2a-17301ccff4b3
The role of Znrf3 and the immune microenvironment in the development of adrenocortical tumorigenesis
Autor:
Antoine Martinez, C. Lucas-Rodrigues, L. Pucheu, Florence Roucher-Boulez, J. Olabe, Christelle Damon-Soubeyrand, Gary D. Hammer, Anne-Marie Lefrançois-Martinez, K.J. Basham, Pierre Val, J. Wilmouth
Publikováno v:
Annales d'Endocrinologie. 82:243-244
Objective Adrenocortical carcinoma (ACC) is an aggressive cancer that originates from steroidogenic cells within the adrenal cortex. The most common alteration in ACC patients is inactivation of the transmembrane E3 ubiquitin-ligase Zinc and Ring Fin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ecab75ea7c036c0a2e2cc9f44cb3931
https://doi.org/10.1016/j.ando.2021.07.069
https://doi.org/10.1016/j.ando.2021.07.069
HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours
Autor:
Amanda Swain, Yacob Weinstein, Pierre Val, Jeffrey C. Francis, Jennifer R. Gardiner, Yoan Renaud, Celso E. Gomez-Sanchez, Anne-Marie Lefrançois-Martinez, Ritika Chauhan, Jérôme Bertherat
Publikováno v:
British Journal of Cancer
British Journal of Cancer, Cancer Research UK, In press, ⟨10.1038/s41416-020-01166-z⟩
British Journal of Cancer, In press, ⟨10.1038/s41416-020-01166-z⟩
British Journal of Cancer, Cancer Research UK, In press, ⟨10.1038/s41416-020-01166-z⟩
British Journal of Cancer, In press, ⟨10.1038/s41416-020-01166-z⟩
BackgroundUnderstanding the pathways that drive adrenocortical carcinoma (ACC) is essential to the development of more effective therapies. This study investigates the role of the transcription factor HOXB9 and other HOX factors in ACC and its treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1ddaad4a11ba093aaa6c90f167387f
https://hal.archives-ouvertes.fr/hal-03100390
https://hal.archives-ouvertes.fr/hal-03100390