Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Anne Marie F. Salapatek"'
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 82:1006-1017
We hypothesized that regional differences in electrophysiological properties exist within the musculature of the feline lower esophageal sphincter (LES) and that they may potentially contribute to functional asymmetry within the LES. Freshly isolated
Autor:
Joan C. Krepinsky, James W. Scholey, Anne Marie F. Salapatek, Damu Tang, Alistair J. Ingram, Kerri Thai, Richard C. Austin, Leighton R. James
Publikováno v:
Kidney International. 66(2):733-745
Activation of mesangial cell MAPK in response to homocys- teine. Background. Alteration in mesangial cell function is central to the progression of glomerular disease in numerous models of chronic renal failure (CRF). Animal models of chronic glomeru
Autor:
Fang Cai, Lulzim Shkreta, Denise D. Belsham, Hong Cui, Anne Marie F. Salapatek, Simon R. Smukler
Publikováno v:
Endocrinology. 145:393-400
Knowledge of how the brain achieves its diverse central control of basic physiology is severely limited by the virtual absence of appropriate cell models. Isolation of clonal populations of unique peptidergic neurons from the hypothalamus will facili
Exogenous Nitric Oxide and Endogenous Glucose-Stimulated β-Cell Nitric Oxide Augment Insulin Release
Publikováno v:
Diabetes. 51:3450-3460
The role nitric oxide (NO) plays in physiological insulin secretion has been controversial. Here we present evidence that exogenous NO stimulates insulin secretion, and that endogenous NO production occurs and is involved in the regulation of insulin
Publikováno v:
Diabetes. 51:S443-S447
Glucagon-like peptide-1 (GLP-1) acts through its G-protein-coupled receptor to enhance glucose-stimulated insulin secretion from pancreatic beta-cells. This is believed to result from modulation of at least two ion channels: ATP-sensitive K(+) (K(ATP
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 282:G288-G299
We have characterized ion-channel identity and density differences along the feline smooth muscle esophagus using patch-clamp recording. Current clamp recording revealed that the resting membrane potential (RMP) of esophageal smooth muscle cells (SMC
Autor:
Peter S. Pennefather, Robert G. Tsushima, Jamie W. Joseph, Anne Marie F. Salapatek, Michael B. Wheeler, Catherine B. Chan, Fang Xu, Domenica De Leo, Timothy S. McQuaid, Xiao Fang Ha
Publikováno v:
Diabetes. 50:1302-1310
In pancreatic beta-cells, glucose metabolism signals insulin secretion by altering the cellular array of messenger molecules. ATP is particularly important, given its role in regulating cation channel activity, exocytosis, and events dependent upon i
Publikováno v:
Molecular Endocrinology. 13:1305-1317
Glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone with powerful antidiabetogenic effects that are thought to be mediated by adenylyl cyclase (AC). Recently, we generated two GLP-1 receptor mutant isoforms (IC3-1 and DM-1) that displayed ef
Publikováno v:
Gastroenterology. 104:810-818
Background; The aim of this study was to investigate the inhibitory innervation of the lower esophageal sphincter in the presence of esophagitis. Methods: Esophagitis was produced in five anesthetized cats with intraesophageal perfusion of HCl. Sphin
Autor:
Anne Marie F Salapatek, James A. Gow, Timothy R. McNamara, Shannon L McCue, Sharon M Klier, J.I. Williams
Publikováno v:
Current medical research and opinion. 26(10)
The purpose of this review is to examine published non-clinical literature on the antihistamine bepotastine besilate, including pharmacokinetic and pharmacologic properties.Standard literature searches using diverse databases were used to find articl