Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Anne Marie, Hickey"'
Autor:
Luciana Meli, Hélder S.C. Barbosa, Anne Marie Hickey, Leyla Gasimli, Gregory Nierode, Maria Margarida Diogo, Robert J. Linhardt, Joaquim M.S. Cabral, Jonathan S. Dordick
Publikováno v:
Stem Cell Research, Vol 13, Iss 1, Pp 36-47 (2014)
We developed a three-dimensional (3D) cellular microarray platform for the high-throughput (HT) analysis of human neural stem cell (hNSC) growth and differentiation. The growth of an immortalized hNSC line, ReNcell VM, was evaluated on a miniaturized
Externí odkaz:
https://doaj.org/article/2dd9aa8b576d447d8ac41d0564d53fc4
Autor:
Kelley W. Moremen, Robert J. Linhardt, Bo Yang, Alison V. Nairn, Leyla Gasimli, Jonathan S. Dordick, Anne Marie Hickey, Mitche dela Rosa, Michael Kulik, Stephen Dalton, Guoyun Li
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1840:1993-2003
Proteoglycans are found on the cell surface and in the extracellular matrix, and serve as prime sites for interaction with signaling molecules. Proteoglycans help regulate pathways that control stem cell fate, and therefore represent an excellent too
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cee00e35fb0dace53cdb1e9e555a881
https://doi.org/10.1016/j.bbagen.2014.01.007
https://doi.org/10.1016/j.bbagen.2014.01.007
Autor:
Anne Marie Hickey, Peter M. Tessier, Ali Reza A. Ladiwala, Jonathan S. Dordick, Joseph M. Perchiacca, Moumita Bhattacharya, Bonnie G. Domigan, Zachary S. Fishman
Publikováno v:
Biotechnology and Bioengineering. 109:1869-1874
Protein aggregation is a common problem during the purification and formulation of therapeutic proteins. Here we report that polyphenolic disaccharides are unusually effective at preventing protein aggregation. We find that two polyphenolic glycoside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916fb679e6ca97e76aaf1c7818a9b38a
https://doi.org/10.1002/bit.24460
https://doi.org/10.1002/bit.24460
Autor:
Toshihiko Toida, Fuming Zhang, Jonathan S. Dordick, Zhenyu Wang, Sayaka Masuko, Robert J. Linhardt, Ujjwal Bhaskar, Anne Marie Hickey, Kyohei Higashi
Publikováno v:
Carbohydrate Research. 346:1962-1966
Ozone is known to add across and cleave carbon-carbon double bonds. Ozonolysis is widely used for the preparation of pharmaceuticals, for bleaching substances and for killing microorganisms in air and water sources. Some polysaccharides and oligosacc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acd5b9b8bd715a77e390c1a4c579570
https://doi.org/10.1016/j.carres.2011.06.004
https://doi.org/10.1016/j.carres.2011.06.004
Autor:
Robert J. Linhardt, Jonathan S. Dordick, Anne Marie Hickey, Fuming Zhang, Amy Suen, Zhenyu Wang, Mellisa Ly, Weihong Zhong
Publikováno v:
Biotechnology and Bioengineering. 107:964-973
Heparosan is an acidic polysaccharide natural product, which serves as the critical precursor in heparin biosynthesis and in the chemoenzymatic synthesis of bioen- gineered heparin. Heparosan is also the capsular polysac- charide of Escherichia coli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e816e6e002e63a0a445062c7a7e0f37b
https://doi.org/10.1002/bit.22898
https://doi.org/10.1002/bit.22898
Autor:
Bongkot Ngamsom, Anne Marie Hickey, Charlotte Wiles, Jennifer A. Littlechild, Gillian M. Greenway, Paul Watts
Publikováno v:
Biotechnology Journal. 4:510-516
A (+)-gamma-lactamase was precipitated, cross-linked and the resulting solid crushed prior to immobilisation within a capillary column microreactor. The microreactor was subsequently used to study enzyme stability, activity, kinetics and substrate sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aeaa10f56ea55d00b210033f91aafe0b
https://doi.org/10.1002/biot.200800302
https://doi.org/10.1002/biot.200800302
Autor:
Anne Marie Hickey, Robert J. Linhardt, Ruchir V. Mundra, Guoyun Li, Ujjwal Bhaskar, Fuming Zhang, Chao Cai, Zhimin Ou, Li Fu, Jonathan S. Dordick
Publikováno v:
Biotechnology progress. 31(5)
The contamination crisis of 2008 has brought to light several risks associated with use of animal tissue derived heparin. Because the total chemical synthesis of heparin is not feasible, a bioengineered approach has been proposed, relying on recombin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed46b6df8ae9f046035b2f37a0246a4
https://pubmed.ncbi.nlm.nih.gov/26147064
https://pubmed.ncbi.nlm.nih.gov/26147064
Effect of eliminase gene (elmA) deletion on heparosan production and shedding in Escherichia coli K5
Publikováno v:
Journal of biotechnology. 165(3-4)
Escherichia coli K5 produces heparosan and sheds it into the growth medium in a temperature dependent manner. The shedding is believed to be controlled, at least in part, by enzyme action on the cell-associated capsular polysaccharide, heparosan. One
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61616c9cb2585d30fe861db7fe742885
https://pubmed.ncbi.nlm.nih.gov/23583654
https://pubmed.ncbi.nlm.nih.gov/23583654
Autor:
Akihiro Onishi, Anne Marie Hickey, Fuming Zhang, Robert J. Linhardt, Eric Sterner, Ujjwal Bhaskar, Jonathan S. Dordick
Publikováno v:
Applied microbiology and biotechnology. 93(1)
Anticoagulant heparin has been shown to possess important biological functions that vary according to its fine structure. Variability within heparin's structure occurs owing to its biosynthesis and animal tissue-based recovery, and adds another dimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d730f3a56795e7e3eca3491006fdfd
https://pubmed.ncbi.nlm.nih.gov/22048616
https://pubmed.ncbi.nlm.nih.gov/22048616
Publikováno v:
Advances in applied microbiology. 65
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fcac10cc97f926dbea699a369493ae7a
https://pubmed.ncbi.nlm.nih.gov/19026861
https://pubmed.ncbi.nlm.nih.gov/19026861