Cardiac-Specific Deletion of Scn8a Mitigates Dravet Syndrome-Associated Sudden Death in Adults.

Autor: King DR; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA., Demirtas M; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA., Tarasov M; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA., Struckman HL; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA., Meng X; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA., Nassal D; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA., Moise N; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA., Miller A; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA., Min D; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA., Soltisz AM; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA., Anne MNK; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Neuroscience, College of Medicine, The Ohio State University, Columbus, Ohio, USA., Alves Dias PA; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Akademika Heyrovského Hradec Králové, Czech Republic., Wagnon JL; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Neuroscience, College of Medicine, The Ohio State University, Columbus, Ohio, USA., Weinberg SH; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA., Hund TJ; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA; Department of Internal Medicine, Division of Cardiovascular Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, USA., Veeraraghavan R; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA., Radwański PB; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA. Electronic address: radwanski.2@osu.edu.

Publikováno v: JACC. Clinical electrophysiology [JACC Clin Electrophysiol] 2024 May; Vol. 10 (5), pp. 829-842. Date of Electronic Publication: 2024 Feb 28.

Caspase-11 regulates lung inflammation in response to house dust mites.

Autor: Abu Khweek A; Department of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA; Department of Biology and Biochemistry, Birzeit University, West Bank, Palestine., Joldrichsen MR; Department of Veterinary Biosciences, The Ohio State University, Columbus OH 43210, USA., Kim E; Department of Veterinary Biosciences, The Ohio State University, Columbus OH 43210, USA., Attia Z; Department of Veterinary Biosciences, The Ohio State University, Columbus OH 43210, USA., Krause K; Department of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA., Daily K; Department of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA., Estfanous S; Department of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA., Hamilton K; Department of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA., Badr A; Department of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA., Anne MNK; Department of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA., Eltobgy M; Department of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA., Corps KN; Department of Veterinary Biosciences, The Ohio State University, Columbus OH 43210, USA., Carafice C; Department of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA., Zhang X; Center for Biostatistics, The Ohio State University, Columbus OH 43210, USA., Gavrilin MA; Department of Internal Medicine, The Ohio State University, Columbus OH 43210, USA., Boyaka PN; Department of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA; Department of Veterinary Biosciences, The Ohio State University, Columbus OH 43210, USA; Infectious Diseases Institute, The Ohio State University, Columbus OH 43210, USA. Electronic address: boyaka.1@osu.edu., Amer AO; Department of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA. Electronic address: amal.amer@osumc.edu.

Publikováno v: Cellular immunology [Cell Immunol] 2021 Dec; Vol. 370, pp. 104425. Date of Electronic Publication: 2021 Aug 29.

Defective immunometabolism pathways in cystic fibrosis macrophages.

Autor: Hamilton K; Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH 43210, USA., Krause K; Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH 43210, USA., Badr A; Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH 43210, USA., Daily K; Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH 43210, USA., Estfanous S; Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH 43210, USA., Eltobgy M; Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH 43210, USA., Khweek AA; Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH 43210, USA; Department of Biology and Biochemistry, Birzeit University, Birzeit, West Bank, Palestine., Anne MNK; Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH 43210, USA., Carafice C; Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH 43210, USA., Baetzhold D; Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH 43210, USA., Tonniges JR; Campus Microscopy and Imaging Facility, The Ohio State University, Columbus, OH 43210, USA., Zhang X; Center for Biostatistics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA., Gavrilin MA; Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43210, USA., Parinandi NL; Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43210, USA., Amer AO; Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH 43210, USA. Electronic address: Amal.Amer@osumc.edu.

Publikováno v: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2021 Jul; Vol. 20 (4), pp. 664-672. Date of Electronic Publication: 2020 Nov 15.

Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo.

Autor: Estfanous S; Department of Microbial Infection and Immunity, Infectious Diseases Institute, Ohio State University, Columbus, OH, USA.; Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt., Krause K; Department of Microbial Infection and Immunity, Infectious Diseases Institute, Ohio State University, Columbus, OH, USA.; Max Planck Unit for the Science of Pathogens, Berlin, Germany., Anne MNK; Department of Microbial Infection and Immunity, Infectious Diseases Institute, Ohio State University, Columbus, OH, USA., Eltobgy M; Department of Microbial Infection and Immunity, Infectious Diseases Institute, Ohio State University, Columbus, OH, USA., Caution K; Department of Microbial Infection and Immunity, Infectious Diseases Institute, Ohio State University, Columbus, OH, USA., Abu Khweek A; Department of Microbial Infection and Immunity, Infectious Diseases Institute, Ohio State University, Columbus, OH, USA.; Department of Biology and Biochemistry, Birzeit University, Birzeit, West Bank, Palestine., Hamilton K; Department of Microbial Infection and Immunity, Infectious Diseases Institute, Ohio State University, Columbus, OH, USA., Badr A; Department of Microbial Infection and Immunity, Infectious Diseases Institute, Ohio State University, Columbus, OH, USA., Daily K; Department of Microbial Infection and Immunity, Infectious Diseases Institute, Ohio State University, Columbus, OH, USA., Carafice C; Department of Microbial Infection and Immunity, Infectious Diseases Institute, Ohio State University, Columbus, OH, USA., Baetzhold D; Department of Microbial Infection and Immunity, Infectious Diseases Institute, Ohio State University, Columbus, OH, USA., Zhang X; Center for Biostatistics, Ohio State University, Columbus, OH, USA., Li T; Department of Microbial Infection and Immunity, Infectious Diseases Institute, Ohio State University, Columbus, OH, USA., Wen H; Department of Microbial Infection and Immunity, Infectious Diseases Institute, Ohio State University, Columbus, OH, USA., Gavrilin MA; Department of Internal Medicine, Ohio State University, Columbus, OH, USA., Haffez H; Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.; Center for Scientific Excellence 'Helwan Structural Biology Research' (HSBR), Helwan University, Cairo, Egypt., Soror S; Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.; Center for Scientific Excellence 'Helwan Structural Biology Research' (HSBR), Helwan University, Cairo, Egypt., Amer AO; Department of Microbial Infection and Immunity, Infectious Diseases Institute, Ohio State University, Columbus, OH, USA. amal.amer@osumc.edu.

Publikováno v: Scientific reports [Sci Rep] 2021 Jan 13; Vol. 11 (1), pp. 855. Date of Electronic Publication: 2021 Jan 13.