Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Anne M. van Harten"'
Autor:
Anne M. van Harten, Ronak Shah, D. Vicky de Boer, Marijke Buijze, Maaike Kreft, Ji-Ying Song, Lisa M. Zürcher, Heinz Jacobs, Ruud H. Brakenhoff
Publikováno v:
Oncogenesis, Vol 13, Iss 1, Pp 1-10 (2024)
Abstract Fanconi anemia (FA) is a rare hereditary disease resulting from an inactivating mutation in the FA/BRCA pathway, critical for the effective repair of DNA interstrand crosslinks (ICLs). The disease is characterized by congenital abnormalities
Externí odkaz:
https://doaj.org/article/a37c66cfac3e4d369e5284cf90649cbc
Autor:
Anne M. van Harten, Ruud H. Brakenhoff
Publikováno v:
van Harten, A M & Brakenhoff, R H 2021, ' Targeted treatment of head and neck (Pre)cancer : Preclinical target identification and development of novel therapeutic applications ', Cancers, vol. 13, no. 11, 2774 . https://doi.org/10.3390/cancers13112774
Cancers, Vol 13, Iss 2774, p 2774 (2021)
Cancers
Cancers, Vol 13, Iss 2774, p 2774 (2021)
Cancers
Simple Summary Head and neck squamous cell carcinomas (HNSCCs) develop from mucosal cells in the oral cavity, pharynx and larynx after either prolonged exposure to tobacco and alcohol, or a transforming infection with high-risk human papillomavirus (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29972e02c97cbcc04ba17c21d32ad0e6
https://research.vumc.nl/en/publications/41ed7df8-ccaf-4b37-a10e-97491bc5942b
https://research.vumc.nl/en/publications/41ed7df8-ccaf-4b37-a10e-97491bc5942b
Autor:
Sanne R. Martens-de Kemp, Victor W. van Beusechem, Renée X. de Menezes, C. René Leemans, Rob M. F. Wolthuis, Ruud H. Brakenhoff, Sonja H. Ganzevles, Keith D. Hunter, D. Vicky de Boer, Marijke Buijze, Anne M. van Harten
Publikováno v:
van Harten, A M, de Boer, D V, Martens-de Kemp, S R, Buijze, M, Ganzevles, S H, Hunter, K D, Leemans, C R, van Beusechem, V W, Wolthuis, R M F, de Menezes, R X & Brakenhoff, R H 2020, ' Chemopreventive targeted treatment of head and neck precancer by Wee1 inhibition ', Scientific Reports, vol. 10, no. 1, 2330 . https://doi.org/10.1038/s41598-020-58509-2
Scientific Reports
Scientific Reports, 10(1):2330. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports, 10(1):2330. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
HPV-negative head and neck squamous cell carcinomas (HNSCCs) develop in precancerous changes in the mucosal lining of the upper-aerodigestive tract. These precancerous cells contain cancer-associated genomic changes and cause primary tumors and local
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2163abab03671df2bd56d3e5e6bf641
https://research.vumc.nl/en/publications/40b478b3-d3e6-450d-8553-84ffc856ca86
https://research.vumc.nl/en/publications/40b478b3-d3e6-450d-8553-84ffc856ca86
Autor:
Anne M. van Harten, Martin A. Rooimans, Richard van der Mast, Marijke Stigter-van Walsum, Marijke Buijze, Arjen Brink, Sanne R. Martens-de Kemp, Ruud H. Brakenhoff, Rob M. F. Wolthuis, Costa Bachas
Publikováno v:
Oncogenesis, 8(7):38. Nature Publishing Group
Oncogenesis
Oncogenesis, Vol 8, Iss 7, Pp 1-16 (2019)
van Harten, A M, Buijze, M, van der Mast, R, Rooimans, M A, Martens-de Kemp, S R, Bachas, C, Brink, A, Stigter-van Walsum, M, Wolthuis, R M F & Brakenhoff, R H 2019, ' Targeting the cell cycle in head and neck cancer by Chk1 inhibition: a novel concept of bimodal cell death ', Oncogenesis, vol. 8, no. 7, 38 . https://doi.org/10.1038/s41389-019-0147-x, https://doi.org/10.1038/s41389-019-0147-x
Oncogenesis
Oncogenesis, Vol 8, Iss 7, Pp 1-16 (2019)
van Harten, A M, Buijze, M, van der Mast, R, Rooimans, M A, Martens-de Kemp, S R, Bachas, C, Brink, A, Stigter-van Walsum, M, Wolthuis, R M F & Brakenhoff, R H 2019, ' Targeting the cell cycle in head and neck cancer by Chk1 inhibition: a novel concept of bimodal cell death ', Oncogenesis, vol. 8, no. 7, 38 . https://doi.org/10.1038/s41389-019-0147-x, https://doi.org/10.1038/s41389-019-0147-x
Head and neck squamous cell carcinomas (HNSCCs) coincide with poor survival rates. The lack of driver oncogenes complicates the development of targeted treatments for HNSCC. Here, we follow-up on two previous genome-wide RNA and microRNA interference
Autor:
Susanne I. Wells, Ruud H. Brakenhoff, Jos B. Poell, Rob M. F. Wolthuis, Marijke Buijze, Anne M. van Harten, C. René Leemans, Arjen Brink
Publikováno v:
Oral Oncol
van Harten, A M, Poell, J B, Buijze, M, Brink, A, Wells, S I, René Leemans, C, Wolthuis, R M F & Brakenhoff, R H 2019, ' Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass ', Oral Oncology, vol. 98, pp. 53-61 . https://doi.org/10.1016/j.oraloncology.2019.09.004
Oral Oncology, 98, 53-61. Elsevier Limited
van Harten, A M, Poell, J B, Buijze, M, Brink, A, Wells, S I, René Leemans, C, Wolthuis, R M F & Brakenhoff, R H 2019, ' Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass ', Oral Oncology, vol. 98, pp. 53-61 . https://doi.org/10.1016/j.oraloncology.2019.09.004
Oral Oncology, 98, 53-61. Elsevier Limited
Introduction Head and neck squamous cell carcinomas (HNSCC) arise in the mucosal lining of the upper aerodigestive tract. Risk factors are exogenous carcinogen exposure, human papillomavirus (HPV) infection, and genetic predisposition such as Fanconi
Autor:
Marijke Buijze, Marijke Stigter-van Walsum, Boudewijn J.M. Braakhuis, Anne M. van Harten, Ruud H. Brakenhoff
Publikováno v:
Cancer Research. 76:4637-4637
Over 90% of all malignant tumors in the head and neck region are squamous cell carcinomas (HNSCC), ranking within the top 10 of most common cancers worldwide. HNSCC arise in the mucosal linings of the upper aerodigestive tract, and known risk factors