Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Anne M. King"'
Autor:
Beni B. Wolf, Ulrik B. Nielsen, Jonathan B. Fitzgerald, Anne M. King, Callum M. Sloss, Olga Burenkova, Neeraj Kohli, Shannon L. Werner, Nastaran Gerami-Moayed, Gege Tan, Mark Sevecka, Raghida Bukhalid, Jeffrey D. Kearns
Supplementary Methods, Figures S1-S11, and Table Legends. Supplementary Methods: description of methods used in the Supplementary figures, expanded description of ELISA assays, and description of the computational model of multiple EGFR ligand antago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0589dd9379473a98d20e9845ac6751
https://doi.org/10.1158/1535-7163.22501833.v1
https://doi.org/10.1158/1535-7163.22501833.v1
Autor:
Beni B. Wolf, Ulrik B. Nielsen, Jonathan B. Fitzgerald, Anne M. King, Callum M. Sloss, Olga Burenkova, Neeraj Kohli, Shannon L. Werner, Nastaran Gerami-Moayed, Gege Tan, Mark Sevecka, Raghida Bukhalid, Jeffrey D. Kearns
Supplementary Tables S2, S3, S4. Structure of the computational model of multiple ligand antagonists: species (Table S2), parameters (Table S3), and Reactions (Table S4).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c534d560032452e0b5101eea8d16d10b
https://doi.org/10.1158/1535-7163.22501827
https://doi.org/10.1158/1535-7163.22501827
Autor:
Beni B. Wolf, Ulrik B. Nielsen, Jonathan B. Fitzgerald, Anne M. King, Callum M. Sloss, Olga Burenkova, Neeraj Kohli, Shannon L. Werner, Nastaran Gerami-Moayed, Gege Tan, Mark Sevecka, Raghida Bukhalid, Jeffrey D. Kearns
Supplementary Table S1. Cell lines and cell culture conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0501a563d004db70756494b7092751e4
https://doi.org/10.1158/1535-7163.22501830
https://doi.org/10.1158/1535-7163.22501830
Autor:
Beni B. Wolf, Ulrik B. Nielsen, Jonathan B. Fitzgerald, Anne M. King, Callum M. Sloss, Olga Burenkova, Neeraj Kohli, Shannon L. Werner, Nastaran Gerami-Moayed, Gege Tan, Mark Sevecka, Raghida Bukhalid, Jeffrey D. Kearns
Supplementary Tables S5, S6, S7, S8. mRNA expression data for EGFR ligands as measured by RNAseq from The Cancer Genome Atlas (TCGA) across 14 cancer indications or by RT-qPCR of colorectal cancer FFPE samples. Table S5: Summary of TCGA datasets incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5782fe1fa8c256671852ceadb513a3f4
https://doi.org/10.1158/1535-7163.22501824
https://doi.org/10.1158/1535-7163.22501824
Autor:
Neeraj Kohli, Olga Burenkova, Mark Sevecka, Ulrik B. Nielsen, Nastaran Gerami-Moayed, Callum M. Sloss, Raghida Bukhalid, Jonathan Fitzgerald, Beni B. Wolf, Shannon L. Werner, Jeffrey D. Kearns, Gege Tan, Anne M. King
Publikováno v:
Molecular Cancer Therapeutics. 14:1625-1636
Although EGFR is a validated therapeutic target across multiple cancer indications, the often modest clinical responses to current anti-EGFR agents suggest the need for improved therapeutics. Here, we demonstrate that signal amplification driven by h
Publikováno v:
Mechanisms of Ageing and Development. 130:384-392
E2A encoded proteins, key transcriptional regulators in B lineage specification and commitment, have been shown to decrease in B cell precursors in old age. E2A regulates genes encoding the surrogate light chain proteins lambda5 and VpreB. In old age
Autor:
Nizar J. Bahlis, Howard R. Terebelo, Hong Yu Liu, Lawrence H. Boise, Anne M. King, Gerald E. Byrne, Despina Kolonias, Kelvin P. Lee, Louise M. Carlson, Bruce L. Levine, Mohamad A. Hussein
Publikováno v:
Blood. 109:5002-5010
Although interactions with bone marrow stromal cells are essential for multiple myeloma (MM) cell survival, the specific molecular and cellular elements involved are largely unknown, due in large part to the complexity of the bone marrow microenviron
Publikováno v:
The Journal of Immunology. 178:3521-3529
The transcriptional regulator E47, encoded by the E2A gene, is crucial to B lymphopoiesis. In BALB/c senescent mice (∼2 years old), the incidence of E47-expressing pro-B cells in vivo and E47 protein steady state levels in B cell precursors in vitr
Publikováno v:
Oncogene. 24:6354-6366
Proapoptotic Bcl-2 family members alter mitochondrial permeability resulting in the release of apoptogenic factors that initiate a caspase cascade. These changes are well described; however, the effects of caspases on mitochondrial function are less
Publikováno v:
European Journal of Immunology. 33:3398-3408
We have observed that immature B cells (IgM(low)IgD(-)) in the bone marrow of adult BALB/c mice exhibit heterogeneity, with a distinct subpopulation ( approximately 4-10%) expressing the CD43/S7 surface protein. These CD43/S7(+) immature B cells ofte