Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Anne M. Galea"'
Autor:
Anne M. Galea, Vincent Murray
Publikováno v:
Cancer Informatics, Vol 6, Pp 315-355 (2008)
Cisplatin is a DNA-damaging anti-cancer agent that is widely used to treat a range of tumour types. Despite its clinical success, cisplatin treatment is still associated with a number of dose-limiting toxic side effects. The purpose of this study was
Externí odkaz:
https://doaj.org/article/b1ef5334671a4e8bb1d8acd3124ce728
Publikováno v:
Bioorganic & Medicinal Chemistry. 40:116191
Cisplatin analogues with an attached DNA-binding moiety represent a potentially effective class of DNA-damaging anti-tumour agents because they possess higher affinities for DNA and different DNA damage profiles compared with cisplatin. In this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acce38d494c25ed82400058ff3606123
https://doi.org/10.1016/j.bmc.2021.116191
https://doi.org/10.1016/j.bmc.2021.116191
Autor:
Anne M. Galea, James D. Mills, John Wilson, Rebecca LeBard, Geoff Kornfeld, Karen J. Gibson, Bill Ashraf, Sven K Delaney
Publikováno v:
Medical Science Educator. 27:673-684
Threshold concepts have a transformative effect on student understanding and are often difficult or ‘troublesome’. Students in undergraduate Medicine and Science must understand many threshold concepts, but are often presented with these ideas in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97ead3c1a5e5c6a90fbc3bf5c00c9f2f
https://doi.org/10.1007/s40670-017-0453-x
https://doi.org/10.1007/s40670-017-0453-x
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 769:93-99
The anti-tumour agent, bleomycin, cleaves DNA to give 3′-phosphoglycolate and 5′-phosphate termini. The removal of 3′-phosphoglycolate to give 3′-OH ends is a very important step in the DNA repair of these lesions. In this study, next-generat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb8c6136b5aae2ccc1f305691f131bb
https://doi.org/10.1016/j.mrfmmm.2014.06.006
https://doi.org/10.1016/j.mrfmmm.2014.06.006
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 14:695-705
There has been a concerted attempt to produce more effective anti-tumour agents based on the widely-used cancer chemotherapeutic agent, cisplatin. One interesting approach is to attach a DNA-affinic chemical group to the cisplatin molecule. This coul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51b3e0b4f249a5f5e8062a4097fd3551
https://doi.org/10.2174/18715206113136660361
https://doi.org/10.2174/18715206113136660361
Publikováno v:
Current Opinion in Cell Biology. 24:509-516
Recent advances have transformed our understanding of lipid droplets (LDs). Once regarded as inert lipid storage granules, LDs are now recognized as multi-functional organelles that affect many aspects of cell biology and metabolism. However, fundame
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49bfde23eedc60d78638fbd829e3f67
https://doi.org/10.1016/j.ceb.2012.05.012
https://doi.org/10.1016/j.ceb.2012.05.012
Autor:
Vincent Murray, Anne M. Galea
Publikováno v:
Chemical Biology & Drug Design. 75:578-589
The interaction of anti-tumour drugs with reconstituted chromatin has been investigated using defined nucleosomal complexes. This allowed the effect of nucleosome cores on drug-induced DNA damage to be assessed for four nitrogen mustard analogues, di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e81372e303eb1e5bf904a91700ac914
https://doi.org/10.1111/j.1747-0285.2010.00969.x
https://doi.org/10.1111/j.1747-0285.2010.00969.x
Autor:
Anne M. Galea, Andrew J. Brown
Publikováno v:
Free Radical Biology and Medicine. 47:880-889
A fascinating link between sterols and molecular oxygen (O(2)) has been a common thread running through the fundamental work of Konrad Bloch, who elucidated the biosynthetic pathway for cholesterol, to recent work supporting a role of sterols in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e5c85d6aef7d9b06659883b0de59a7
https://doi.org/10.1016/j.freeradbiomed.2009.06.027
https://doi.org/10.1016/j.freeradbiomed.2009.06.027
Autor:
Vincent Murray, Anne M. Galea
Publikováno v:
Cancer Informatics, Vol 6, Pp 315-355 (2008)
Cancer Informatics
Cancer Informatics, Vol 6 (2008)
Cancer Informatics
Cancer Informatics, Vol 6 (2008)
Cisplatin is a DNA-damaging anti-cancer agent that is widely used to treat a range of tumour types. Despite its clinical success, cisplatin treatment is still associated with a number of dose-limiting toxic side effects. The purpose of this study was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e3180de3fd668b31a258a2250035a0
http://la-press.com/article.php?article_id=854
http://la-press.com/article.php?article_id=854
Publikováno v:
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 19(6)
In this study, the DNA sequence specificity of four DNA-targeted 9-aminoacridine carboxamide Pt complexes was compared with cisplatin, using two specially constructed plasmid templates. One plasmid contained 5'-CG and 5'-GA insert sequences while the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e93506c906a78f365b37207d4ffae9
https://pubmed.ncbi.nlm.nih.gov/24827388
https://pubmed.ncbi.nlm.nih.gov/24827388