Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Anne M. Fourie"'
Autor:
Kevin M.-C. Lee, Tanya Lupancu, Leon Chang, Carl L. Manthey, Martha Zeeman, Anne M. Fourie, John A. Hamilton
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-13 (2024)
Abstract Objectives We have previously reported using gene-deficient mice that the interleukin (IL)-23p19 subunit is required for the development of innate immune-driven arthritic pain and disease. We aimed to explore here, using a number of in vivo
Externí odkaz:
https://doaj.org/article/888be7f191d14f12b7b922d2269b3be3
Autor:
Anne M. Fourie, Xiaoli Cheng, Leon Chang, Carrie Greving, Xinyi Li, Beverly Knight, David Polidori, Aaron Patrick, Trpta Bains, Ruth Steele, Samantha J. Allen, Raymond J. Patch, Chengzao Sun, Sandeep Somani, Ashok Bhandari, David Liu, Keith Huie, Shu Li, Michael A. Rodriguez, Xiaohua Xue, Arun Kannan, Teddy Kosoglou, Jonathan P. Sherlock, Jennifer Towne, M. Claire Holland, Nishit B. Modi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The interleukin (IL)-23 pathway is a pathogenic driver in psoriasis, psoriatic arthritis, and inflammatory bowel disease. Currently, no oral therapeutics selectively target this pathway. JNJ-77242113 is a peptide targeting the IL-23 receptor
Externí odkaz:
https://doaj.org/article/a5c225b49e4844578be75fc534d1282c
Autor:
Xiaohua Xue, Aimee De Leon-Tabaldo, Rosa Luna-Roman, Glenda Castro, Michael Albers, Freddy Schoetens, Samuel DePrimo, Damayanthi Devineni, Thomas Wilde, Steve Goldberg, Thomas Hoffmann, Anne M. Fourie, Robin L. Thurmond
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The nuclear receptor retinoid-related orphan receptor gamma t (RORγt) plays a critical role in driving Th17 cell differentiation and expansion, as well as IL-17 production in innate and adaptive immune cells. The IL-23/IL-17 axis is implica
Externí odkaz:
https://doaj.org/article/b41726b0e6ed4617b45bd45046be2ee9
Autor:
Xiaohua Xue, Aimee De Leon-Tabaldo, Rosa Luna-Roman, Glenda Castro, Michael Albers, Freddy Schoetens, Samuel DePrimo, Damayanthi Devineni, Thomas Wilde, Steve Goldberg, Olaf Kinzel, Thomas Hoffmann, Anne M. Fourie, Robin L. Thurmond
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/8350d4860faf488fa4942f7353c6f062
Autor:
Mariela L. Pauli, Xuejun Liu, Mio Nakamura, Richard Ahn, Michael Rosenblum, Tina Bhutani, Wai-Ping Fung-Leung, Anne M. Fourie, Shrishti Bhattarai, Wilson Liao, Hsin-Wen Chang, Kristen M. Beck, Isabelle M. Sanchez, J. Liu, Priscila Muñoz-Sandoval, Eric J. Yang, Zhi-Ming Huang, Jeffrey P. North, Sahil Sekhon, Sarah T. Arron, Ernesto Munoz
Publikováno v:
The Journal of allergy and clinical immunology, vol 147, iss 6
Background Psoriasis is an inflammatory, IL-17–driven skin disease in which autoantigen-induced CD8+ T cells have been identified as pathogenic drivers. Objective Our study focused on comprehensively characterizing the phenotypic variation of CD8+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8bac68f4ef347b989337f557936872
https://escholarship.org/uc/item/0tx1w67f
https://escholarship.org/uc/item/0tx1w67f
Autor:
Jared, Liu, Hsin-Wen, Chang, Zhi-Ming, Huang, Mio, Nakamura, Sahil, Sekhon, Richard, Ahn, Priscila, Munoz-Sandoval, Shrishti, Bhattarai, Kristen M, Beck, Isabelle M, Sanchez, Eric, Yang, Mariela, Pauli, Sarah T, Arron, Wai-Ping, Fung-Leung, Ernesto, Munoz, Xuejun, Liu, Tina, Bhutani, Jeffrey, North, Anne M, Fourie, Michael D, Rosenblum, Wilson, Liao
Publikováno v:
J Allergy Clin Immunol
BACKGROUND: Psoriasis is an inflammatory, IL-17-driven skin disease in which autoantigen-induced CD8(+) T cells have been identified as pathogenic drivers. OBJECTIVE: Our study focused on comprehensively characterizing the phenotypic variation of CD8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7e55bbe151feb378468972bdc8d5f7b
https://pubmed.ncbi.nlm.nih.gov/33309739
https://pubmed.ncbi.nlm.nih.gov/33309739
Autor:
Anne M. Fourie, Steven D. Goldberg, Maxwell D. Cummings, Christoph Steeneck, Thomas Hoffmann, Xiaohua Xue, Michael Albers, Christian Gege, John Spurlino, Kristi A. Leonard, Marina I. Nelen, Cindy Milligan, James P. Edwards, Gerald Kleymann, Olaf Kinzel, Thomas Schlüter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1446-1455
The nuclear receptor retinoic acid receptor-related orphan receptor gamma t (RORγt) is a transcription factor that drives Th17 cell differentiation and IL-17 production in both innate and adaptive immune cells. The IL-23/IL-17 pathway is implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26717ddfdaa64c66ae493163cdbd20a
https://doi.org/10.1016/j.bmcl.2018.03.093
https://doi.org/10.1016/j.bmcl.2018.03.093
Autor:
Anne M. Fourie, Glenda Castro, John Spurlino, Rachel Nishimura, Xiaohua Xue, Maxwell D. Cummings, Maud Urbanski, Kevin D. Kreutter, Umar Maharoof, Aihua Wang, David A. Kummer, J. Kent Barbay, James P. Edwards, Kristi A. Leonard, Ronald L. Wolin, Hariharan Venkatesan, Marta Cristina Abad, Celine Schalk-Hihi, Craig R. Woods, Cynthia M. Milligan, Joan Pierce, Virginia M. Tanis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:5277-5283
We identified 6-substituted quinolines as modulators of the retinoic acid receptor-related orphan receptor gamma t (RORγt). The synthesis of this class of RORγt modulators is reported, and optimization of the substituents at the quinoline 6-positio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa2690b51b17762744f29691e68c6d5
https://doi.org/10.1016/j.bmcl.2017.10.027
https://doi.org/10.1016/j.bmcl.2017.10.027
Autor:
Maxwell D. Cummings, Thomas Schlueter, David A. Kummer, J. Kent Barbay, Krystal Herman, Craig R. Woods, John Spurlino, Kristi A. Leonard, Cynthia M. Milligan, Hariharan Venkatesan, Rachel Nishimura, Michael Albers, Ronald L. Wolin, James P. Edwards, Marina I. Nelen, Xiaohua Xue, Anne M. Fourie, Virginia M. Tanis, Brian Scott
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(12)
We have previously reported the syntheses of a series of 3,6-disubstituted quinolines as modulators of the retinoic acid receptor-related orphan receptor gamma t (RORγt). These molecules are potent binders but are high molecular weight and they exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9ffb81bdf736a1e085c1c3d7cca302
https://pubmed.ncbi.nlm.nih.gov/31010722
https://pubmed.ncbi.nlm.nih.gov/31010722
Autor:
Xiaohua Xue, Christian Gege, Christoph Steeneck, Andreas Schulz, Kristi A. Leonard, Gerald Kleymann, Michael Albers, Steven D. Goldberg, Olaf Kinzel, Thomas J. Hoffmann, Thomas Schlüter, Maxwell D. Cummings, James P. Edwards, Anne M. Fourie, Brian Scott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127174
Starting from previously identified thiazole-2-carboxamides exemplified by compound 1/6, two new series of RORγt inverse agonists with significantly improved aqueous solubility, ADME parameters and oral PK properties were discovered. These scaffolds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71298a25d93e2b8353b18c097db7f1f9
https://doi.org/10.1016/j.bmcl.2020.127174
https://doi.org/10.1016/j.bmcl.2020.127174