Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response.

Autor: Edubiel A Alpizar-Sosa, Nur Raihana Binti Ithnin, Wenbin Wei, Andrew W Pountain, Stefan K Weidt, Anne M Donachie, Ryan Ritchie, Emily A Dickie, Richard J S Burchmore, Paul W Denny, Michael P Barrett

Publikováno v: PLoS Neglected Tropical Diseases, Vol 16, Iss 9, p e0010779 (2022)

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin.

Externí odkaz: https://doaj.org/article/d236c07b263b428594e99eab4248e1b2

Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response

Autor: Edubiel A. Alpizar-Sosa, Nur Raihana Binti Ithnin, Wenbin Wei, Andrew W. Pountain, Stefan K. Weidt, Anne M. Donachie, Ryan Ritchie, Emily A. Dickie, Richard J. S. Burchmore, Paul W. Denny, Michael P. Barrett

Publikováno v: PLOS Neglected Tropical Diseases, 2022, Vol.16(9), pp.e0010779 [Peer Reviewed Journal]

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211f168830cff69dc45cb173585a9956
http://dro.dur.ac.uk/37233/

Sialylation of Campylobacter jejuni lipo-oligosaccharides: impact on phagocytosis and cytokine production in mice.

Autor: Ruth Huizinga, Alistair S Easton, Anne M Donachie, Jim Guthrie, Wouter van Rijs, Astrid Heikema, Louis Boon, Janneke N Samsom, Bart C Jacobs, Hugh J Willison, Carl S Goodyear

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e34416 (2012)

Guillain-Barré syndrome (GBS) is a post-infectious polyradiculoneuropathy, frequently associated with antecedent Campylobacter jejuni (C. jejuni) infection. The presence of sialic acid on C. jejuni lipo-oligosaccharide (LOS) is considered a risk fac

Externí odkaz: https://doaj.org/article/a38e1a9a0b294a259dadfed98e6c5ecd

Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages

Autor: Sanaa S. Botros, Harry P. de Koning, Geert Jan Sterk, Titilola D. Kalejaiye, Sheng Xiang Huang, Zainab Abbasi, Jane C. Munday, Samia William, Susanne Schroeder, David G. Brown, Marco Siderius, Abdel-Nasser A. Sabra, Ali H. Alghamdi, Anne M. Donachie, Stefan Kunz, Daniel Paape, Rob Leurs, Charles S. Hoffman

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008447 (2020)
PLoS Neglected Tropical Diseases
Munday, J C, Kunz, S, Kalejaiye, T D, Siderius, M, Schroeder, S, Paape, D, Alghamdi, A H, Abbasi, Z, Huang, S X, Donachie, A M, William, S, Sabra, A N, Sterk, G J, Botros, S S, Brown, D G, Hoffman, C S, Leurs, R & de Koning, H P 2020, ' Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages ', PLoS Neglected Tropical Diseases, vol. 14, no. 7, e0008447, pp. 1-29 . https://doi.org/10.1371/journal.pntd.0008447
PLoS Neglected Tropical Diseases, 14(7):e0008447, 1-29. Public Library of Science

Only a single drug against schistosomiasis is currently available and new drug development is urgently required but very few drug targets have been validated and characterised. However, regulatory systems including cyclic nucleotide metabolism are em

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23253a9acc0ed8a32f771fdc86c2bd3
https://doi.org/10.1371/journal.pntd.0008447

Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense

Autor: Marcel Kaiser, Kiyoshi Kita, Godwin U. Ebiloma, Emmanuel Oluwadare Balogun, Tomoo Shiba, Christophe Dardonville, Anne M. Donachie, Lucía Abad Gil, Shigeharu Harada, Harry P. de Koning, Daniel Ken Inaoka, Tomás Herraiz, Teresa Díaz Ayuga

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

African trypanosomiasis is a neglected parasitic disease that is still of great public health relevance, and a severe impediment to agriculture in endemic areas. The pathogens possess certain unique metabolic features that can be exploited for the de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05df7a3b7103b2ec92dbacda39a93302
http://hdl.handle.net/10261/167649