Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Anne M. Byford"'
Autor:
G. Paul Matherne, Marguerite M. Crawford, Amy R. Lankford, Rachael J. Cerniway, Sara E. Regan, Anne M. Byford
Publikováno v:
Drug Development Research. 58:439-446
Myocardial damage from ischemia/reperfusion injury can be minimized through endogenous protective mechanisms, including activation of A 1 adenosine receptors. Transgenic mice with cardiac-specific A 1 adenosine receptor overexpression (A 1 AR Trans)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7581456807714a8959ceeefea5c65a5
https://doi.org/10.1002/ddr.10189
https://doi.org/10.1002/ddr.10189
Autor:
Amy R. Lankford, Anne M. Byford, Sara E. Regan, Marty W. Mayo, G. Paul Matherne, Rachael J. Cerniway, Michael Broad
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 284:H859-H866
We tested the hypothesis that myocardial ischemia-reperfusion (I/R)-induced apoptosis is attenuated in transgenic mice overexpressing cardiac A1 adenosine receptors. Isolated hearts from transgenic (TG, n = 19) and wild-type (WT, n = 22) mice underwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe397c771f925bcc455198446b4ccc0
https://doi.org/10.1152/ajpheart.00251.2002
https://doi.org/10.1152/ajpheart.00251.2002
Autor:
Racheel J. Cerniway, David G. L. Van Wylen, Amy R. Lankford, Anne M. Byford, R. Ray Morrison, G. Paul Matherne, John P. Headrick
Publikováno v:
Basic Research in Cardiology. 97:232-238
Myocardial A1 adenosine receptor (A1AR) overexpression protects hearts from ischemia-reperfusion injury; however, the effects during anoxia are unknown. We evaluated responses to anoxia-reoxygenation in wild-type (WT) and transgenic (Trans) hearts wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7466b938867a7e3a8d3cd8d1616957
https://doi.org/10.1007/s003950200016
https://doi.org/10.1007/s003950200016
Autor:
G. Paul Matherne, Anne M. Byford, John P. Headrick, R. Ray Morrison, Naomi S. Gauthier, R Jones
Publikováno v:
Drug Development Research. 45:402-409
The advent of transgenic techniques provides a unique opportunity to study adenosine receptor-mediated cardioprotection. Transgenic A 1 receptor overexpression increases myocardial protection without impairing intrinsic function, but at the expense o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::615b4f399335e5f94fd69980294842ec
https://doi.org/10.1002/(sici)1098-2299(199811/12)45:3/4<402::aid-ddr41>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199811/12)45:3/4<402::aid-ddr41>3.0.co
Publikováno v:
Proceedings of the National Academy of Sciences. 94:6541-6546
Activation of myocardial A 1 adenosine receptors (A 1 AR) protects the heart from ischemic injury. In this study transgenic mice were created using the cardiac-specific α-myosin heavy chain promoter and rat A 1 AR cDNA. Heart membranes from two tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca948993f0ac3581499f3f4ce96df1d7
https://doi.org/10.1073/pnas.94.12.6541
https://doi.org/10.1073/pnas.94.12.6541
Autor:
Rachael J. Cerniway, Brent A. French, Stuart S. Berr, Zequan Yang, G. Paul Matherne, Anne M. Byford
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 282(3)
Previous studies have shown that high-level (300-fold normal) cardiac overexpression of A1-adenosine receptors (A1-ARs) in transgenic (TG) mice protects isolated hearts against ischemia-reperfusion injury. However, this high level of overexpression i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbb0822cf606cd2848d283f576f8c4e
https://pubmed.ncbi.nlm.nih.gov/11834491
https://pubmed.ncbi.nlm.nih.gov/11834491
Autor:
Jason Nigel John Peart, Alyssa R. Stell, R. Ray Morrison, G. Paul Matherne, R Jones, John P. Headrick, Anne M. Byford
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 279(3)
The role of A1adenosine receptors (A1AR) in ischemic preconditioning was investigated in isolated crystalloid-perfused wild-type and transgenic mouse hearts with increased A1AR. The effect of preconditioning on postischemic myocardial function, lacta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1048c7c62072f0ef6eee2c80510bec
https://pubmed.ncbi.nlm.nih.gov/10993769
https://pubmed.ncbi.nlm.nih.gov/10993769
Publikováno v:
Anesthesiology, 93(2), 497-509. Lippincott Williams and Wilkins
Background Local anesthetics inhibit lipid mediator signaling (lysophosphatidate, thromboxane) by acting on intracellular domains of the receptor or on the G protein. On receptors for polar agonists, the ligand-binding pocket could form an additional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34abcf98a1c219ccda2a47cb4fb80a4d
https://pubmed.ncbi.nlm.nih.gov/10910501
https://pubmed.ncbi.nlm.nih.gov/10910501
Publikováno v:
Pediatric Research. 43:24-24
“Preconditioning” the heart with brief periods of ischemia protects it from sustained ischemia such as can occur during surgical correction of congenital heart disease. One possible mechanism of this protection involves the activation of A1 adeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::719783726d4c825fb6c3216d0b909fdf
https://doi.org/10.1203/00006450-199804001-00148
https://doi.org/10.1203/00006450-199804001-00148
Publikováno v:
Pediatric Research. 39:32-32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f2dee11557893c5868a829bfa3e13b1
https://doi.org/10.1203/00006450-199604001-00196
https://doi.org/10.1203/00006450-199604001-00196