Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Anne M. Brodeur"'
Autor:
Judith L. Treadway, David W. Piotrowski, R. Kirk McPherson, Jana Polivkova, Anne M. Brodeur, Shenping Liu, Bernard Hulin, David D. Boyer, Stephen J. Orena, Xiayang Qiu, Maria A. Vanvolkenburg, Dennis E. Danley, Donald C. Wilder, Janice C. Parker, Shawn D. Doran, Carolyn B. Soglia, Mark Ammirati, Kim M. Andrews
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1991-1995
A series of 4-substituted proline amides was synthesized and evaluated as inhibitors of dipeptidyl pepdidase IV for the treatment of type 2 diabetes. (3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb8cf65715687f0bc8ee1e7e04655a6
https://doi.org/10.1016/j.bmcl.2009.02.041
https://doi.org/10.1016/j.bmcl.2009.02.041
Autor:
Hong Wang, Judith L. Treadway, Maria A. Vanvolkenburg, Anne M. Brodeur, L. D. Mcclure, Shawn D. Doran, Jay S. Lillquist, Kim M. Andrews, Stephen J. Orena, Stephen W. Wright, Donald C. Wilder, Jana Polivkova, R. Kirk McPherson, Mark Ammirati, Janice C. Parker, Thanh V. Olson, Walter C. Soeller, Xiayang Qiu, Carolyn B. Soglia, Dennis E. Danley
Publikováno v:
Journal of Medicinal Chemistry. 49:3068-3076
Inhibitors of the glucagon-like peptide-1 (GLP-1) degrading enzyme dipeptidyl peptidase IV (DPP-IV) have been shown to be effective treatments for type 2 diabetes in animal models and in human subjects. A novel series of cis-2,5-dicyanopyrrolidine al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7225566352cae2523ca6fd2fce0bf4d9
https://doi.org/10.1021/jm0600085
https://doi.org/10.1021/jm0600085
Autor:
Maria A. Vanvolkenburg, L. D. Mcclure, Stephen J. Orena, Kim M. Andrews, Benjamin N. Rocke, Jay S. Lillquist, Judith L. Treadway, Stephen W. Wright, Zhengrong Zhao, Thanh V. Olson, Janice C. Parker, Shawn D. Doran, Walter C. Soeller, R. Kirk McPherson, Anne M. Brodeur, Cox Eric David, Carolyn B. Soglia, Shenping Liu, Mark Ammirati, Dennis E. Danley
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(20)
A series of pyrrolidine based inhibitors of dipeptidyl peptidase IV were developed from a high throughput screening hit for the treatment of type 2 diabetes. Potency, selectivity, and pharmacokinetic properties were optimized resulting in the identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f927a94060b522e9278cf93b62b98b
https://pubmed.ncbi.nlm.nih.gov/17822893
https://pubmed.ncbi.nlm.nih.gov/17822893
Autor:
Jing Chen, Mary Theresa Didiuk, Nicole Barucci, Beijing Tan, Timothy P. Rolph, Peter J. Oates, Anne M. Brodeur, Leena Patel, Spiros Liras, Patricia Bourassa, Paul DaSilva-Jardine, Kevin J. Filipski, Laurel Sweet, Christopher S. Jones, John D. Knafels, Jeffrey A. Pfefferkorn, Nahor Haddish-Berhane, Karen Atkinson, Karki Kapil Kumar, Gary Erik Aspnes, David R. Derksen, Wei Song, David E. Perregaux, Joshua R. Dunetz, William M. Hungerford, Jeffrey W. Corbett, James Saenz, James A. Landro, Cong Huang, Francis Bourbounais, Margit MacDougall, Chulho Choi, Martin A. Berliner, Arindrajit Basak, Hud Lawrence Risley, Jian-Cheng Li, Xiayang Qiu, Jianwei Bian, Alan Robertson, Judith L. Treadway, John Litchfield, Angel Guzman-Perez, Shenping Liu, John William Benbow, John C. Pettersen, Theresa D’Aquila, Meihua Tu, Christian Perreault, Anthony Lai Ling, Rena Burbey, David A. Beebe, Kevin Daniel Freeman-Cook, Robert J. Aiello, Mark Ammirati, Xi Song, Amanda L. Lapworth
Publikováno v:
MedChemComm. 2:828
Glucokinase is a key regulator of glucose homeostasis and small molecule activators of this enzyme represent a promising opportunity for the treatment of Type 2 diabetes. Several glucokinase activators have advanced to clinical studies and demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acd44038e0dcaf826f1fe7dbf044dc84
https://doi.org/10.1039/c1md00116g
https://doi.org/10.1039/c1md00116g