Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Anne M Verhagen"'
Autor:
Anton Zalewski, Arna Andrews, Isabelle Glauser, Marcel Mischnik, Matthew P. Hardy, Anne M Verhagen, Kerstin Emmrich, Sabine Pestel, Con Panousis, Philipp Claar, Victor Turnbull, Chao-Guang Chen, Michael J. Wilson, Gregory T. Bass, Elmar Raquet, Steve K. Dower, Jenny Chia, Thomas Weimer, Vesna Tomasetig
Publikováno v:
Journal of Thrombosis and Haemostasis. 19:2710-2725
BACKGROUND We have recently reported on a recombinant von Willebrand factor (VWF) D'D3 albumin fusion protein (rD'D3-FP) developed to extend the half-life of coagulation factor VIII (FVIII) for the treatment of hemophilia A. Based on predictive model
Autor:
Fiona J. Houghton, Anne M Verhagen, Elizabeth Hinde, Paul A. Gleeson, Steven K. Dower, Andreas Pannek
Publikováno v:
Molecular biology of the cell. 33(1)
The neonatal Fc receptor (FcRn) is responsible for the recycling of endocytosed albumin and IgG, and contributes to their long plasma half-life. We recently identified an FcRn-dependent recycling pathway from macropinosomes in macrophages; however, l
Autor:
Dale I. Godfrey, Jason Simmonds, Katherine Woods, Matthias Pelzing, Stephen J. Kent, Gino Vairo, Chris Hudson, Anne M Verhagen, Darryl N. Johnson, Andreas Behren, Bhupinder Pal, Marc Rigau, Adam P Uldrich, Simone Ostrouska, Andrew Hammet, Zheng Ruan, Hamish E G McWilliam, Andrew D. Nash, Candani Tutuka, Jose A Villadangos, Nicholas A Gherardin, Thomas S Fulford, Con Panousis, Eugene Maraskovsky, Christian Kurts, Adam K. Wheatley, Jonathan Cebon
Publikováno v:
Science. 367
A weird way to recognize phosphoantigens In contrast to the well-studied αβ T cells, which recognize peptide antigens presented by major histocompatibility complex (MHC) and MHC-like molecules, how γδ T cells recognize antigens remains largely a
Autor:
Paul A. Gleeson, Shirley Taylor, Jenny Chia, Isabelle Glauser, Jade Louber, Gregory T. Bass, Steve K. Dower, Anne M Verhagen
Publikováno v:
The Journal of Biological Chemistry
The neonatal Fc receptor (FcRn) has a pivotal role in albumin and IgG homeostasis. Internalized IgG captured by FcRn under acidic endosomal conditions is recycled to the cell surface where exocytosis and a shift to neutral pH promote extracellular Ig
Autor:
Alireza Rezvani-Sharif, Piet H. van der Graaf, Sabine Pestel, Oliver Ghobrial, Steve K. Dower, Eva Herzog, Anne M Verhagen, Ineke L. Muir, Markus Brechmann, Douglas Chung, Sivarmurthy Krupa
Publikováno v:
Blood. 138:4240-4240
Background and Aims: Replacement FIX therapy (rIX) is an effective treatment for hemophilia B even with undetectable levels in the blood 1. However, the mechanistic reason for hemostasis with low plasma levels is not well understood. There is growing
Autor:
Wei Hong Toh, Steve K. Dower, Jenny Chia, Gregory T. Bass, Anne M Verhagen, Paul A. Gleeson, Ismail S. Mahmoud, Jade Louber
Publikováno v:
Journal of Cell Science. 133
The neonatal Fc receptor (FcRn) rescues albumin and IgG from degradation following endocytosis and thereby extends the half-life of these plasma proteins. However, the pathways for the uptake of these soluble FcRn ligands, and the recycling itinerary
Autor:
Zuben E. Sauna, Miguel A. Escobar, John Blangero, Satish Kumar, Vincent P. Diego, Juan M. Peralta, Raja Rajalingam, Sarah Williams-Blangero, Jerry S. Powell, Marcio Almeida, Roberta Kellerman, Tom E. Howard, Paul V. Lehmann, Eugene Maraskovsky, Long V. Dinh, Nigel S. Key, Anne M Verhagen, Joanne E. Curran, Marco Hofmann, Huy Huynh, Bernadette W. Luu, Yara A. Park
Publikováno v:
Journal of thrombosis and haemostasis : JTHREFERENCES. 18(1)
Background Plasma-derived (pd) or recombinant (r) therapeutic factor VIII proteins (FVIIIs) are infused to arrest/prevent bleeding in patients with hemophilia A (PWHA). However, FVIIIs are neutralized if anti-FVIII-antibodies (inhibitors) develop. Ac
Autor:
Marc Rigau, Simone Ostrouska, Tom Fulford, Darryl Neil Johnson, Katherine Woods, Zheng Ruan, Hamish McWilliam, Christopher Hudson, Candani Tutuka, Adam K Wheatley, Stephen J Kent, Jose A Villadangos, Bhupinder Pal, Christian Kurts, Jason Simmonds, Matthias Pelzing, Andrew D Hammet, Anne M Verhagen, Gino Vairo, Eugene Maraskovsky, Con Panousis, Nicholas Anthony Gherardin, Jonathan Cebon, Dale Ian Godfrey, Andreas Behren, Adam Peter Uldrich
Publikováno v:
The Journal of Immunology. 204:140.12-140.12
Humans have a minor lymphocyte population of gamma-delta (γδ) T cells. The majority of these express a recombined Vγ9Vδ2 T cell receptor (TCR) attractive to immunotherapy. This distinct TCR conveys reactivity to phosphorylated antigens (pAg) that
Publikováno v:
European journal of cell biology. 96(5)
Many membrane cargoes undergo endocytosis and intracellular recycling to the plasma membrane via the early endosomes and the recycling endosomes. However whether specific sorting signals are required for transport from early endosomes to recycling en
Autor:
Martina Fuchsberger, Ankita Goradia, Tracy A. Willson, Robyn Starr, Anne M. Verhagen, Adam P Uldrich, Lei Shong Lau, Mark J. Smyth, Warren S. Alexander
Publikováno v:
The Journal of Immunology. 183:4537-4544
Suppressor of cytokine signaling (SOCS)-1 is a critical inhibitor of IFN-γ signal transduction in vivo, but the precise biochemical mechanism of action of SOCS-1 is unclear. Studies in vitro have shown that SOCS-1 binds to Jaks and inhibits their ca