Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Anne M Pruznak"'
Autor:
Jennifer L Steiner, Anne M Pruznak, Gina Deiter, Maithili Navaratnarajah, Lydia Kutzler, Scot R Kimball, Charles H Lang
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99582 (2014)
Sepsis decreases skeletal muscle protein synthesis in part by impairing mTOR activity and the subsequent phosphorylation of 4E-BP1 and S6K1 thereby controlling translation initiation; however, the relative importance of changes in these two downstrea
Externí odkaz:
https://doaj.org/article/cc23a4fbb4b94a558fbeb6766d0c17fe
Publikováno v:
Journal of Orthopaedic Research. 33:1846-1853
Fatty degeneration of the rotator cuff muscles is an irreversible change resulting from chronic rotator cuff tear and is associated with poor clinical outcomes following rotator cuff repair. We evaluated the effect of Tamoxifen, a competitive estroge
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 304:R887-R898
The present study sought to determine whether the protein catabolic response in skeletal muscle produced by chronic alcohol feeding was exaggerated in aged rats. Adult (3 mo) and aged (18 mo) female F344 rats were fed a nutritionally complete liquid
Publikováno v:
Metabolism. 58:787-797
The present study tests the hypotheses that local bioavailability of insulin-like growth factor I (IGF-I) is capable of regulating muscle protein balance and that muscle-directed IGF-I can selectively maintain muscle mass during bacterial infection.
Publikováno v:
The Journal of Nutrition. 138:1887-1894
Several stress conditions are characterized by activation of 5'-AMP-activated protein kinase (AMPK) and the development of leucine resistance in skeletal muscle. In the present study, we determined whether direct activation of the AMPK by 5-aminoimid
Autor:
Robert A. Frost, Pengxiang She, Anne M. Pruznak, Rachel Lantry, Ly Q. Hong-Brown, Charles H. Lang, Thomas C. Vary
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 295:E964-E973
The mechanism by which human immunodeficiency virus (HIV)-1 infection in humans leads to the erosion of lean body mass is poorly defined. Therefore, the purpose of the present study was to determine whether transgenic (Tg) rats that constitutively ov
Publikováno v:
Alcoholism, clinical and experimental research. 39(8)
Background The production of fibrosis in response to chronic alcohol abuse is well recognized in liver but has not been fully characterized in striated muscle and may contribute to functional impairment. Therefore, the purpose of this study was to us
Publikováno v:
Journal of Cellular Biochemistry. 94:419-431
Decreased translation initiation adversely impacts protein synthesis and contributes to the myocardial dysfunction produced by sepsis. Therefore, the purpose of the present study was to identify sepsis-induced changes in signal transduction pathways
Autor:
Margaret M. Palopoli, Charles H. Lang, Anne M. Pruznak, Robert A. Frost, Nobuko Deshpande, Thomas C. Vary
Publikováno v:
Alcoholism: Clinical & Experimental Research. 28:1758-1767
Background: The purpose of this study was to characterize the ability of alcohol to suppress insulin-like growth factor (IGF)-I stimulation of ribosomal S6 kinase 1 (S6K1) and 4E-BP1 phosphorylation, which are central elements in the signal transduct
Autor:
Charles H. Lang, Maithili Navaratnarajah, Anne M. Pruznak, Gina Deiter, Scot R. Kimball, Lydia Kutzler, Jennifer L. Steiner
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 6, p e99582 (2014)
PLoS ONE, Vol 9, Iss 6, p e99582 (2014)
Sepsis decreases skeletal muscle protein synthesis in part by impairing mTOR activity and the subsequent phosphorylation of 4E-BP1 and S6K1 thereby controlling translation initiation; however, the relative importance of changes in these two downstrea