Zobrazeno 1 - 10
of 572
pro vyhledávání: '"Anne M Fagan"'
Autor:
Peter R Millar, Brian A Gordon, Patrick H Luckett, Tammie LS Benzinger, Carlos Cruchaga, Anne M Fagan, Jason J Hassenstab, Richard J Perrin, Suzanne E Schindler, Ricardo F Allegri, Gregory S Day, Martin R Farlow, Hiroshi Mori, Georg Nübling, The Dominantly Inherited Alzheimer Network, Randall J Bateman, John C Morris, Beau M Ances
Publikováno v:
eLife, Vol 12 (2023)
Background: Estimates of ‘brain-predicted age’ quantify apparent brain age compared to normative trajectories of neuroimaging features. The brain age gap (BAG) between predicted and chronological age is elevated in symptomatic Alzheimer disease (
Externí odkaz:
https://doaj.org/article/9106fa4debe1403fbea1c9196d43eb90
Autor:
Muhammad Ali, Yun Ju Sung, Fengxian Wang, Maria V Fernández, John C Morris, Anne M Fagan, Kaj Blennow, Henrik Zetterberg, Amanda Heslegrave, Per M Johansson, Johan Svensson, Bengt Nellgård, Alberto Lleó, Daniel Alcolea, Jordi Clarimon, Lorena Rami, José Luis Molinuevo, Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Christian Haass, Michael Ewers, Johannes Levin, Martin R Farlow, Richard J Perrin, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dominantly Inherited Alzheimer Network (DIAN), Carlos Cruchaga
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0267298 (2022)
Two genetic variants in strong linkage disequilibrium (rs9536314 and rs9527025) in the Klotho (KL) gene, encoding a transmembrane protein, implicated in longevity and associated with brain resilience during normal aging, were recently shown to be ass
Externí odkaz:
https://doaj.org/article/40df32b713724f238a80e782ea644465
Autor:
John C Morris, Susan L Stark, Rebecca M Bollinger, Audrey Keleman, Regina Thompson, Elizabeth Westerhaus, Anne M Fagan, Tammie LS Benzinger, Suzanne E Schindler, Chengjie Xiong, David Balota, Beau M Ances
Publikováno v:
BMJ Open, Vol 11, Iss 9 (2021)
Introduction Progression to symptomatic Alzheimer disease (AD) occurs slowly over a series of preclinical stages. Declining functional mobility may be an early indicator of loss of brain network integration and may lead to an increased risk of experi
Externí odkaz:
https://doaj.org/article/48f5aaf10d1c432faa119e41b4653dbe
Autor:
Marc Suárez‐Calvet, Anja Capell, Miguel Ángel Araque Caballero, Estrella Morenas‐Rodríguez, Katrin Fellerer, Nicolai Franzmeier, Gernot Kleinberger, Erden Eren, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Katrina Paumier, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Mathias Jucker, Colin L Masters, Martin N Rossor, John M Ringman, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers, Christian Haass, the Dominantly Inherited Alzheimer Network, the Alzheimer's Disease Neuroimaging Initiative
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 12, Pp 1-21 (2018)
Abstract Progranulin (PGRN) is predominantly expressed by microglia in the brain, and genetic and experimental evidence suggests a critical role in Alzheimer's disease (AD). We asked whether PGRN expression is changed in a disease severity‐specific
Externí odkaz:
https://doaj.org/article/1fe5940f23884dd28924de1e2c522e1d
Autor:
Seonjoo Lee, Molly E Zimmerman, Atul Narkhede, Sara E Nasrabady, Giuseppe Tosto, Irene B Meier, Tammie L S Benzinger, Daniel S Marcus, Anne M Fagan, Nick C Fox, Nigel J Cairns, David M Holtzman, Virginia Buckles, Bernardino Ghetti, Eric McDade, Ralph N Martins, Andrew J Saykin, Colin L Masters, John M Ringman, Stefan Fӧrster, Peter R Schofield, Reisa A Sperling, Keith A Johnson, Jasmeer P Chhatwal, Stephen Salloway, Stephen Correia, Clifford R Jack, Michael Weiner, Randall J Bateman, John C Morris, Richard Mayeux, Adam M Brickman, Dominantly Inherited Alzheimer Network
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0195838 (2018)
INTRODUCTION:White matter hyperintensity (WMH) volume on MRI is increased among presymptomatic individuals with autosomal dominant mutations for Alzheimer's disease (AD). One potential explanation is that WMH, conventionally considered a marker of ce
Externí odkaz:
https://doaj.org/article/ed7c9a6ecadf43f2bcdf1faf91145ddd
Publikováno v:
Frontiers in Neurology, Vol 6 (2015)
Our understanding of the pathogenesis of Alzheimer disease (AD) has been greatly influenced by investigation of rare families with autosomal dominant mutations that cause early onset AD. Mutations in the genes coding for Amyloid Precursor Protein (AP
Externí odkaz:
https://doaj.org/article/eccc6b5eeb7b43afb55f79947c8e4e0f
Autor:
John S K Kauwe, Matthew H Bailey, Perry G Ridge, Rachel Perry, Mark E Wadsworth, Kaitlyn L Hoyt, Lyndsay A Staley, Celeste M Karch, Oscar Harari, Carlos Cruchaga, Benjamin J Ainscough, Kelly Bales, Eve H Pickering, Sarah Bertelsen, Alzheimer's Disease Neuroimaging Initiative, Anne M Fagan, David M Holtzman, John C Morris, Alison M Goate
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004758 (2014)
Cerebrospinal fluid (CSF) 42 amino acid species of amyloid beta (Aβ42) and tau levels are strongly correlated with the presence of Alzheimer's disease (AD) neuropathology including amyloid plaques and neurodegeneration and have been successfully use
Externí odkaz:
https://doaj.org/article/80123cca0e78463c93754376f1acd06d
Autor:
Bruno A Benitez, Celeste M Karch, Yefei Cai, Sheng Chih Jin, Breanna Cooper, David Carrell, Sarah Bertelsen, Lori Chibnik, Julie A Schneider, David A Bennett, Alzheimer's Disease Neuroimaging Initiative, Genetic and Environmental Risk for Alzheimer's Disease Consortium GERAD, Anne M Fagan, David Holtzman, John C Morris, Alison M Goate, Carlos Cruchaga
Publikováno v:
PLoS Genetics, Vol 9, Iss 8, p e1003685 (2013)
The primary constituents of plaques (Aβ42/Aβ40) and neurofibrillary tangles (tau and phosphorylated forms of tau [ptau]) are the current leading diagnostic and prognostic cerebrospinal fluid (CSF) biomarkers for AD. In this study, we performed deep
Externí odkaz:
https://doaj.org/article/ded5243138e04b93b067beebc377bbd0
Autor:
Richard J Perrin, Jacqueline E Payton, James P Malone, Petra Gilmore, Alan E Davis, Chengjie Xiong, Anne M Fagan, R Reid Townsend, David M Holtzman
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64314 (2013)
Biomarkers are required for pre-symptomatic diagnosis, treatment, and monitoring of neurodegenerative diseases such as Alzheimer's disease. Cerebrospinal fluid (CSF) is a favored source because its proteome reflects the composition of the brain. Idea
Externí odkaz:
https://doaj.org/article/18320a1706b94b3aab85df95fd4776fb
Autor:
Rebecca Craig-Schapiro, Max Kuhn, Chengjie Xiong, Eve H Pickering, Jingxia Liu, Thomas P Misko, Richard J Perrin, Kelly R Bales, Holly Soares, Anne M Fagan, David M Holtzman
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18850 (2011)
Clinicopathological studies suggest that Alzheimer's disease (AD) pathology begins ∼10-15 years before the resulting cognitive impairment draws medical attention. Biomarkers that can detect AD pathology in its early stages and predict dementia onse
Externí odkaz:
https://doaj.org/article/e976640c1c5a4ccea2c12642381fa6f5