Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Anne Lyne Schmitz"'
Autor:
Alexy Promonet, Ismaël Padioleau, Yaqun Liu, Lionel Sanz, Anna Biernacka, Anne-Lyne Schmitz, Magdalena Skrzypczak, Amélie Sarrazin, Clément Mettling, Maga Rowicka, Krzysztof Ginalski, Frédéric Chedin, Chun-Long Chen, Yea-Lih Lin, Philippe Pasero
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
While R-loops can alter cell homeostasis, it is unclear what determines their toxicity. Here, the authors, by using Top1 knockdown as a tool to enhance the formation of R-loops at certain genomic sites, reveal and characterize a proportion of R-loops
Externí odkaz:
https://doaj.org/article/bd1932962b864455ac3b032015f1a0ac
Autor:
Julien N. Bianco, Valérie Bergoglio, Yea-Lih Lin, Marie-Jeanne Pillaire, Anne-Lyne Schmitz, Julia Gilhodes, Amelie Lusque, Julien Mazières, Magali Lacroix-Triki, Theodoros I. Roumeliotis, Jyoti Choudhary, Jérôme Moreaux, Jean-Sébastien Hoffmann, Hélène Tourrière, Philippe Pasero
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Oncogene-induced replication stress (RS) promotes cancer development. Here, the authors report that cancer cells adapt to oncogene-induced RS by overexpressing downstream components of ATR-CHK1 pathway, Claspin and Timeless, which have protective rol
Externí odkaz:
https://doaj.org/article/fdf314771754477295f673e54990011e
Autor:
Anna Biernacka, Philippe Pasero, Chun-Long Chen, Maga Rowicka, Krzysztof Ginalski, Ismael Padioleau, Lionel A. Sanz, Frédéric Chédin, Yaqun Liu, Magdalena Skrzypczak, Clément Mettling, Amélie Sarrazin, Anne Lyne Schmitz, Alexy Promonet, Yea-Lih Lin
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-17858-2⟩
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-17858-2⟩
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
R-loops have both positive and negative impacts on chromosome functions. To identify toxic R-loops in the human genome, here, we map RNA:DNA hybrids, replication stress markers and DNA double-strand breaks (DSBs) in cells depleted for Topoisomerase I
Autor:
Yea-Lih Lin, Vincenzo Costanzo, Karina Zadorozhny, Anne-Lyne Schmitz, Flavie Coquel, Alexandra Cribier, Maria Joao Silva, Philippe Pasero, Bernard S. Lopez, Hervé Técher, Clément Mettling, Amélie Sarrazin, Antoine Barthe, Andrei Chabes, Elodie Dardillac, Jadwiga Nieminuszczy, Monsef Benkirane, Alexy Promonet, L. Krejci, Wojciech Niedzwiedz, Sushma Sharma
Publikováno v:
Comptes Rendus Biologies
Comptes Rendus Biologies, Elsevier, 2020, 343 (1), pp.9-21. ⟨10.5802/crbiol.10⟩
Comptes Rendus Biologies, Elsevier, 2020, 343 (1), pp.9-21. ⟨10.5802/crbiol.10⟩
International audience; DNA replication is an extremely complex process, involving thousands of replication forks progressing along chromosomes. These forks are requently slowed down or stopped by various obstacles, such as secondary DNA structures,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d55e0061a47b221acde166cb0f1fb4
https://hal.archives-ouvertes.fr/hal-03083188/document
https://hal.archives-ouvertes.fr/hal-03083188/document
Autor:
Theodoros I. Roumeliotis, Jérôme Moreaux, Julia Gilhodes, Julien Mazieres, Marie-Jeanne Pillaire, Hélène Tourrière, Valérie Bergoglio, Julien N Bianco, Jean-Sébastien Hoffmann, Yea-Lih Lin, Amélie Lusque, Anne-Lyne Schmitz, Jyoti S. Choudhary, Magali Lacroix-Triki, Philippe Pasero
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.910. ⟨10.1038/s41467-019-08886-8⟩
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, 2019, 10 (1), pp.910. ⟨10.1038/s41467-019-08886-8⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.910. ⟨10.1038/s41467-019-08886-8⟩
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, 2019, 10 (1), pp.910. ⟨10.1038/s41467-019-08886-8⟩
Oncogene-induced replication stress (RS) promotes cancer development but also impedes tumor growth by activating anti-cancer barriers. To determine how cancer cells adapt to RS, we have monitored the expression of different components of the ATR-CHK1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9bd9dd19f534d15b2c9e730aad4259
https://hal.archives-ouvertes.fr/hal-02047561
https://hal.archives-ouvertes.fr/hal-02047561
Autor:
Philippe Pasero, Maria-Joao Silva, Anne-Lyne Schmitz, Alexandra Cribier, Hervé Técher, Amélie Sarrazin, Elodie Dardillac, Clément Mettling, Antoine Barthe, Jadwiga Nieminuszczy, Bernard S. Lopez, Andrei Chabes, Yea-Lih Lin, Flavie Coquel, Lumir Krejci, Sushma Sharma, Vincenzo Costanzo, Karina Zadorozhny, Wojciech Niedzwiedz, Monsef Benkirane, Alexy Promonet
Publikováno v:
Nature
Nature, Nature Publishing Group, 2018, 557 (7703), pp.57-61. ⟨10.1038/s41586-018-0050-1⟩
Comptes Rendus Biologies
Comptes Rendus Biologies, Elsevier, 2020, 343 (1), pp.9-21. ⟨10.5802/crbiol.10⟩
Nature, Nature Publishing Group, 2018, 557 (7703), pp.57-61. ⟨10.1038/s41586-018-0050-1⟩
Comptes Rendus Biologies
Comptes Rendus Biologies, Elsevier, 2020, 343 (1), pp.9-21. ⟨10.5802/crbiol.10⟩
International audience; DNA replication is an extremely complex process, involving thousands of replication forks progressing along chromosomes. These forks are requently slowed down or stopped by various obstacles, such as secondary DNA structures,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdceae5a70236e3ddce41e110a40ce9
https://hal.archives-ouvertes.fr/hal-01791237
https://hal.archives-ouvertes.fr/hal-01791237