Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Anne Le Digarcher"'
1
Akademický článek
Functional mapping of microRNA promoters with dCas9 fused to transcriptional regulators
Autor: Pradeep Kumar, Mathilde Courtes, Céline Lemmers, Anne Le Digarcher, Ilda Coku, Arnaud Monteil, Charles Hong, Annie Varrault, Runhua Liu, Lizhong Wang, Tristan Bouschet
Publikováno v: Frontiers in Genetics, Vol 14 (2023)
MicroRNAs are small non-coding RNAs that control gene expression during development, physiology, and disease. Transcription is a key factor in microRNA abundance and tissue-specific expression. Many databases predict the location of microRNA transcri
Externí odkaz: https://doaj.org/article/e5016ad41c2b4af986f6effad044b0df
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2
Akademický článek
Quantifying Genomic Imprinting at Tissue and Cell Resolution in the Brain
Autor: Annie Varrault, Emeric Dubois, Anne Le Digarcher, Tristan Bouschet
Publikováno v: Epigenomes, Vol 4, Iss 3, p 21 (2020)
Imprinted genes are a group of ~150 genes that are preferentially expressed from one parental allele owing to epigenetic marks asymmetrically distributed on inherited maternal and paternal chromosomes. Altered imprinted gene expression causes human b
Externí odkaz: https://doaj.org/article/a6c2e5b48aeb40d4a8cc9c9f1949b471
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3
Akademický článek
Expression at the imprinted dlk1-gtl2 locus is regulated by proneural genes in the developing telencephalon.
Autor: Julie Seibt, Olivier Armant, Anne Le Digarcher, Diogo Castro, Vidya Ramesh, Laurent Journot, François Guillemot, Pierre Vanderhaeghen, Tristan Bouschet
Publikováno v: PLoS ONE, Vol 7, Iss 11, p e48675 (2012)
Imprinting is an epigenetic mechanism that restrains the expression of about 100 genes to one allele depending on its parental origin. Several imprinted genes are implicated in neurodevelopmental brain disorders, such as autism, Angelman, and Prader-
Externí odkaz: https://doaj.org/article/11a74fbaaed240cb9bcaebc6c3dae780
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5
CRISPR Activation/Inhibition Experiments Reveal that Expression of Intronic MicroRNA miR-335 Depends on the Promoter Activity of its Host Gene Mest
Autor: Tristan Bouschet, Charles C. Hong, Ilda Coku, Céline Lemmers, Arnaud Monteil, Anne Le Digarcher, Mathilde Courtes, Annie Varrault
MicroRNAs are small non-coding RNAs that act as rheostats to modulate gene expression during development, physiology, and disease. Approximately half of mammalian microRNAs are intronic. It is unknown whether intronic miRNA transcription depends on t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f5e8275b6cd41051d54874122bf174e
https://doi.org/10.1101/2021.09.15.458166
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6
Quantifying Genomic Imprinting at Tissue and Cell Resolution in the Brain
Autor: Tristan Bouschet, Emeric Dubois, Anne Le Digarcher, Annie Varrault
Publikováno v: Epigenomes
Epigenomes, MDPI, 2020, 4 (3), pp.21. ⟨10.3390/epigenomes4030021⟩
Epigenomes, 2020, 4 (3), pp.21. ⟨10.3390/epigenomes4030021⟩
Epigenomes, Vol 4, Iss 21, p 21 (2020)
International audience; Imprinted genes are a group of ~150 genes that are preferentially expressed from one parental allele owing to epigenetic marks asymmetrically distributed on inherited maternal and paternal chromosomes. Altered imprinted gene e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29389ff64846fbf0e48b46860f84daae
https://hal.archives-ouvertes.fr/hal-03364539/document
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7
Mouse parthenogenetic embryonic stem cells with biparental-like expression of imprinted genes generate cortical-like neurons that integrate into the injured adult cerebral cortex
Autor: Armen Badalyan, Laurent Journot, Annie Varrault, Chantal Ripoll, Benoit Girard, Federica Bertaso, Anne Le Digarcher, Sigrid Eckardt, Isabelle Sassetti, Céline Meusnier, K. John McLaughlin, Tristan Bouschet
Publikováno v: STEM CELLS
STEM CELLS, AlphaMed Press, 2018, 36 (2), pp.192-205. ⟨10.1002/stem.2721⟩
One strategy for stem cell-based therapy of the cerebral cortex involves the generation and transplantation of functional, histocompatible cortical-like neurons from embryonic stem cells (ESCs). Diploid parthenogenetic Pg-ESCs have recently emerged a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac01a8684127998a354f0454f226e96
https://europepmc.org/articles/PMC5785436/
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8
In Vitro Corticogenesis from Embryonic Stem Cells Recapitulates the In Vivo Epigenetic Control of Imprinted Gene Expression
Autor: Vincent Demolombe, Robert Sabatier, Laurent Journot, Satya K. Kota, Chloé Maurizy, Philippe Arnaud, Stéphanie Rialle, Anne Le Digarcher, Stéphanie Maupetit-Mehouas, Emeric Dubois, Annie Varrault, Patricia Cavelier, Robert Feil, Mikael Pezet, Céline Meusnier, Christelle Reynes, Sabine Nidelet, Tristan Bouschet
Publikováno v: Cerebral Cortex
Cerebral Cortex, Oxford University Press (OUP), 2017, 〈10.1093/cercor/bhw102〉
Cerebral Cortex, Oxford University Press (OUP), 2017, ⟨10.1093/cercor/bhw102⟩
Cerebral Cortex, Oxford University Press (OUP), 2016, 〈10.1093/cercor/bhw102〉
Cerebral Cortex, 2017, ⟨10.1093/cercor/bhw102⟩
International audience; In vitro corticogenesis from embryonic stem cells (ESCs) is an attractive model of cortical development and a promising tool for corticaltherapy. It is unknown to which extent epigenetic mechanisms crucial for cortex developme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbc0dce06e9c2c5b544a04bbc53ae29
https://hal.archives-ouvertes.fr/hal-01934516
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9
A systems-level approach to parental genomic imprinting: the imprinted gene network includes extracellular matrix genes and regulates cell cycle exit and differentiation
Autor: Hala, Al Adhami, Brendan, Evano, Anne, Le Digarcher, Charlotte, Gueydan, Emeric, Dubois, Hugues, Parrinello, Christelle, Dantec, Tristan, Bouschet, Annie, Varrault, Laurent, Journot
Publikováno v: Genome research. 25(3)
Genomic imprinting is an epigenetic mechanism that restrains the expression of ∼ 100 eutherian genes in a parent-of-origin-specific manner. The reason for this selective targeting of genes with seemingly disparate molecular functions is unclear. In
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a960a9bae43e0e8453793114e36ef777
https://pubmed.ncbi.nlm.nih.gov/25614607
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10
Genome-wide profiling of G protein-coupled receptors in cerebellar granule neurons using high-throughput, real-time PCR
Autor: Benjamin Maurel, Christelle Dantec, Anne Le Digarcher, Laurent Journot
Publikováno v: BMC Genomics, Vol 12, Iss 1, p 241 (2011)
BMC Genomics
BMC Genomics, BioMed Central, 2011, 12 (1), pp.241. ⟨10.1186/1471-2164-12-241⟩
BMC Genomics, 2011, 12 (1), pp.241. ⟨10.1186/1471-2164-12-241⟩
Background G protein-coupled receptors (GPCRs) are major players in cell communication, regulate a whole range of physiological functions during development and throughout adult life, are affected in numerous pathological situations, and constitute s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ffae57156ac06c953b21dca9bbe2158
https://doi.org/10.1186/1471-2164-12-241
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