Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Anne Laure Vallier"'
Autor:
Petra Mlcochova, Dami Collier, Allyson Ritchie, Sonny M. Assennato, Myra Hosmillo, Neha Goel, Bo Meng, Krishna Chatterjee, Vivien Mendoza, Nigel Temperton, Leo Kiss, Leo C. James, Katarzyna A. Ciazynska, Xiaoli Xiong, John A.G. Briggs, James A. Nathan, Federica Mescia, Laura Bergamaschi, Hongyi Zhang, Petros Barmpounakis, Nikos Demeris, Richard Skells, Paul A. Lyons, John Bradley, Steven Baker, Jean Pierre Allain, Kenneth G.C. Smith, Rachel Bousfield, Michael Wilson, Dominic Sparkes, Glenn Amoroso, Effrosyni Gkrania-Klotsas, Susie Hardwick, Adrian Boyle, Ian Goodfellow, Ravindra K. Gupta, Stephen Baker, Gordon Dougan, Ravi Gupta, Paul J. Lehner, Paul Lyons, Nicholas J. Matheson, Mark Toshner, Michael P. Weekes, Nick Brown, Martin Curran, Surendra Palmar, David Enoch, Daniel Chapman, Ashley Shaw, Sherly Jose, Areti Bermperi, Julie Ann Zerrudo, Evgenia Kourampa, Laura Watson, Jieniean Worsley, Caroline Saunders, Ranalie de Jesus, Jason Domingo, Ciro Pasquale, Bensi Vergese, Phoebe Vargas, Marivic Fabiculana, Marlyn Perales, Lee Mynott, Elizabeth Blake, Amy Bates, Anne-Laure Vallier, Alexandra Williams, David Phillips, Edmund Chiu, Alex Overhill, Nicola Ramenatte, Jamal Sipple, Steven Frost, Helena Knock, Richard Hardy, Emily Foster, Fiona Davidson, Viona Rundell, Purity Bundi, Richmond Abeseabe, Sarah Clark, Isabel Vicente, Anne Elmer, Carla Ribeiro, Jenny Kourampa, Jane Kennet, Jane Rowlands, Anne Meadows, Criona O’Brien, Rebecca Rastall, Cherry Crucusio, Sarah Hewitt, Jane Price, Jo Calder, Laura Canna, Ashlea Bucke, Hugo Tordesillas, Julie Harris, Valentina Ruffolo, Barbara Graves, Helen Butcher, Daniela Caputo, Emma Le Gresley, Benjamin J. Dunmore, Jennifer Martin, Ekaterina Legchenko, Carmen Treacy, Christopher Huang, Jennifer Wood, Rachel Sutcliffe, Josh Hodgson, Joy Shih, Stefan Graf, Zhen Tong, Tobias Tilly, Ciara O’Donnell, Kelvin Hunter, Linda Pointon, Nicole Pond, Marta Wylot, Emma Jones, Stuart Fawke, Ben Bullman, Lori Turner, Isobel Jarvis, Ommar Omarjee, Aloka De Sa, Joe Marsden, Ariana Betancourt, Marianne Perera, Maddie Epping, Nathan Richoz, Georgie Bower, Rahul Sharma, Francesca Nice, Oisin Huhn, Natalia Savoinykh Yarkoni, Nika Romashova, Daniel Lewis, Andrew Hinch, Chiara Cossetti, Mateusz Strezlecki, Richard Grenfell, Hannah Stark, Neil Walker, Kathy Stirrups, Nigel Ovington, Eleanor Dewhust, Emily Li, Sofia Papadia, Nathalie Kingston, Andrew Lever, Estee Torok, William Hamilton, Grant Hall, Aminu Jahun, Yasmin Chaudhry, Malte Pinckert, Iliana Georgana, Anna Yakovleva, Laura Caller, Sarah Caddy, Theresa Feltwell, Fahad Khokhar, Luke Meredith, Charlotte Holdcroft, Surendra Parmar
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 6, Pp 100099- (2020)
Summary: Rapid COVID-19 diagnosis in the hospital is essential, although this is complicated by 30%–50% of nose/throat swabs being negative by SARS-CoV-2 nucleic acid amplification testing (NAAT). Furthermore, the D614G spike mutant dominates the p
Externí odkaz:
https://doaj.org/article/f56b9ae7c1d24d12996d40bd0463ae07
Autor:
Dami A. Collier, Sonny M. Assennato, Ben Warne, Nyarie Sithole, Katherine Sharrocks, Allyson Ritchie, Pooja Ravji, Matthew Routledge, Dominic Sparkes, Jordan Skittrall, Anna Smielewska, Isobel Ramsey, Neha Goel, Martin Curran, David Enoch, Rhys Tassell, Michelle Lineham, Devan Vaghela, Clare Leong, Hoi Ping Mok, John Bradley, Kenneth G.C. Smith, Vivienne Mendoza, Nikos Demiris, Martin Besser, Gordon Dougan, Paul J. Lehner, Mark J. Siedner, Hongyi Zhang, Claire S. Waddington, Helen Lee, Ravindra K. Gupta, Stephen Baker, Ian Goodfellow, Paul Lyons, Nicholas J. Matheson, Mark Toshner, Michael P. Weekes, Nick Brown, Surendra Palmar, Daniel Chapman, Ashley Shaw, Vivien Mendoza, Sherly Jose, Areti Bermperi, Julie Ann Zerrudo, Evgenia Kourampa, Caroline Saunders, Ranalie de Jesus, Jason Domingo, Ciro Pasquale, Bensi Vergese, Phoebe Vargas, Marivic Fabiculana, Marlyn Perales, Richard Skells, Lee Mynott, Elizabeth Blake, Amy Bates, Anne-laure Vallier, Alexandra Williams, David Phillips, Edmund Chiu, Alex Overhill, Nicola Ramenante, Jamal Sipple, Steven Frost, Helena Knock, Richard Hardy, Emily Foster, Fiona Davidson, Viona Rundell, Purity Bundi, Richmond Abeseabe, Sarah Clark, Isabel Vicente
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 5, Pp 100062- (2020)
Summary: There is an urgent need for rapid SARS-CoV-2 testing in hospitals to limit nosocomial spread. We report an evaluation of point of care (POC) nucleic acid amplification testing (NAAT) in 149 participants with parallel combined nasal and throa
Externí odkaz:
https://doaj.org/article/618dc2c7482d47aeb29159bc9e1875ff
Autor:
Helena Earl, Louise Hiller, Anne-Laure Vallier, Shrushma Loi, Karen McAdam, Luke Hughes-Davies, Daniel Rea, Donna Howe, Kerry Raynes, Helen B Higgins, Maggie Wilcox, Chris Plummer, Betania Mahler-Araujo, Elena Provenzano, Anita Chhabra, Sophie Gasson, Claire Balmer, Jean E Abraham, Carlos Caldas, Peter Hall, Bethany Shinkins, Christopher McCabe, Claire Hulme, David Miles, Andrew M Wardley, David A Cameron, Janet A Dunn
Publikováno v:
Health Technology Assessment, Vol 24, Iss 40 (2020)
Background: The addition of adjuvant trastuzumab to chemotherapy has significantly improved outcomes for people with human epidermal growth factor receptor 2 (HER2)-positive, early, potentially curable breast cancer. Twelve months’ trastuzumab, tes
Externí odkaz:
https://doaj.org/article/66820d8dae1b478ea55fa5063313fffe
Autor:
Louise Hiller, Janet A. Dunn, Shrushma Loi, Anne-Laure Vallier, Donna L. Howe, David A. Cameron, David Miles, Andrew M. Wardley, Helena M. Earl
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-7 (2018)
Abstract Background Twelve months treatment is the current standard of care for adjuvant trastuzumab in patients with HER2 positive early breast cancer however the optimal duration is not known. Persephone is a non-inferiority randomised controlled t
Externí odkaz:
https://doaj.org/article/3428b56c983c4bb691972bfa1e9a8297
Autor:
Helena M. Earl, Paul P.D. Pharoah, Carlos Caldas, Christopher J. Poole, Janet A. Dunn, Sarah J. Bowden, Linda Jones, Russell Burns, Louise Hiller, Anne-Laure Vallier, Richard Hardy, Susan Ingle, Jonathan Tyrer, Leila Dorling, Qi Guo, Jean E. Abraham
Purpose: Associations between taxane-related sensory neuropathy (TRSN) and single-nucleotide polymorphisms (SNP) have previously been reported, but few have been replicated in large, independent validation studies. This study evaluates the associatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910ca8484e173bc19a9b74cffea65744
https://doi.org/10.1158/1078-0432.c.6522995
https://doi.org/10.1158/1078-0432.c.6522995
Autor:
Helena M. Earl, Paul P.D. Pharoah, Carlos Caldas, Christopher J. Poole, Janet A. Dunn, Sarah J. Bowden, Linda Jones, Russell Burns, Louise Hiller, Anne-Laure Vallier, Richard Hardy, Susan Ingle, Jonathan Tyrer, Leila Dorling, Qi Guo, Jean E. Abraham
PDF file - 237KB, Supplementary Table 1: Published Studies of Putative Functional SNPs Supplementary Table 2a: Drug Regimens and Doses of Taxanes by Study Supplementary Table 2b: Comparison of Toxicity grades/rates by recruiting trial in PGSNPS inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508c9a46258ea6b32495d0b31edfa9e8
https://doi.org/10.1158/1078-0432.22455335
https://doi.org/10.1158/1078-0432.22455335
Autor:
Sabine C. Linn, Carlos Caldas, Javier Cortès, William Gallagher, Cristina Saura, René Bernards, Aurelia de Vries Schultink, Margaret Schot, Petra Nederlof, Else Platte, Hilde Rosing, José-Manuel Perez-Garcia, Emma Beddowes, Maurizio Callari, Harm van Tinteren, Sanjeev Kumar, Constanza Linossi, Erik van Werkhoven, Greig Dougall, Anne-Laure Vallier, Javier Garcia-Corbacho, Ingrid A.M. Mandjes, Mariette Schrier, Meiling Gao, Karin Beelen, Mafalda Oliveira, Annelot G.J. van Rossum, Richard D. Baird
Pharmacokinetics: Z-endoxifen levels per taselisib dose level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8c3ce186a1e98a096fd80e837ef085
https://doi.org/10.1158/1078-0432.22471986.v1
https://doi.org/10.1158/1078-0432.22471986.v1
Autor:
Sabine C. Linn, Carlos Caldas, Javier Cortès, William Gallagher, Cristina Saura, René Bernards, Aurelia de Vries Schultink, Margaret Schot, Petra Nederlof, Else Platte, Hilde Rosing, José-Manuel Perez-Garcia, Emma Beddowes, Maurizio Callari, Harm van Tinteren, Sanjeev Kumar, Constanza Linossi, Erik van Werkhoven, Greig Dougall, Anne-Laure Vallier, Javier Garcia-Corbacho, Ingrid A.M. Mandjes, Mariette Schrier, Meiling Gao, Karin Beelen, Mafalda Oliveira, Annelot G.J. van Rossum, Richard D. Baird
Purpose:The strategy of combining endocrine therapy with PI3K-mTOR inhibition has shown promise in estrogen receptor (ER)–positive breast cancer, but new agents and combinations with a better therapeutic index are urgently needed. Taselisib is a po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38dbcd046b3ffe289c7694d6875e0bdd
https://doi.org/10.1158/1078-0432.c.6528075
https://doi.org/10.1158/1078-0432.c.6528075
Autor:
Sabine C. Linn, Carlos Caldas, Javier Cortès, William Gallagher, Cristina Saura, René Bernards, Aurelia de Vries Schultink, Margaret Schot, Petra Nederlof, Else Platte, Hilde Rosing, José-Manuel Perez-Garcia, Emma Beddowes, Maurizio Callari, Harm van Tinteren, Sanjeev Kumar, Constanza Linossi, Erik van Werkhoven, Greig Dougall, Anne-Laure Vallier, Javier Garcia-Corbacho, Ingrid A.M. Mandjes, Mariette Schrier, Meiling Gao, Karin Beelen, Mafalda Oliveira, Annelot G.J. van Rossum, Richard D. Baird
Supplementary Methods Text
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1182c2cadec2b5dc324fec46d078953
https://doi.org/10.1158/1078-0432.22471977.v1
https://doi.org/10.1158/1078-0432.22471977.v1
Autor:
Lynsey M Drewett, Karen A Pinilla, Louise Grybowicz, Jerome Wulff, Alimu Dayimu, Nikolaos Demiris, Jessica Martin, Camila Maida de Pontes, Nicola Johnson, Caron Harvey, Erdem Demir, Kimberley St John Green, James Jones, Gemma Young, Anne-Laure Vallier, Wendi Qian, Andrea Machin, Karen McAdam, Rebecca Roylance, Ellen R Copson, Anne Armstrong, Nicola Levitt, Elena Provenzano, Marc Tischkowitz, Emma McMurtry, Helena Earl, Jean E Abraham
Publikováno v:
Cancer Research. 82:OT2-24
Background: Triple Negative Breast Cancers (TNBC) are a biologically diverse and aggressive subgroup lacking targeted therapy. Germline BRCA (gBRCA) breast cancer and TNBC share some phenotypic and molecular similarities, with 10%-20% of TNBC patient