The Shank3Venus/Venus knock in mouse enables isoform-specific functional studies of Shank3a

Autor: Nathalie Bouquier, Sophie Sakkaki, Fabrice Raynaud, Anne-Laure Hemonnot-Girard, Vincent Seube, Vincent Compan, Federica Bertaso, Julie Perroy, Enora Moutin

Publikováno v: Frontiers in Neuroscience. 16

BackgroundShank3 is a scaffolding protein essential for the organization and function of the glutamatergic postsynapse. Monogenic mutations in SHANK3 gene are among the leading genetic causes of Autism Spectrum Disorders (ASD). The multiplicity of Sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4651b55bf24b858b7eb9fc123ae7323b
https://doi.org/10.3389/fnins.2022.1081010

De nouvelles techniques pour dévoiler le rôle des cellules gliales du cerveau

Autor: Hélène Hirbec, Carole Escartin, Lucile Ben Haim, Anne-Laure Hemonnot-Girard

Publikováno v: médecine/sciences
médecine/sciences, 2021, 37 (1), pp.59-67. ⟨10.1051/medsci/2020253⟩
médecine/sciences, EDP Sciences, 2021, 37 (1), pp.59-67. ⟨10.1051/medsci/2020253⟩

Brain function relies on complex interactions between neurons and different types of glial cells, such as astrocytes, microglia and oligodendrocytes. The relatively young field of "gliobiology" is thriving. Thanks to various technical innovations, it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7285679b30dfe8d074dbcfd1ce0642
https://doi.org/10.1051/medsci/2020253

Relative Contribution of Amyloid-β Plaque Associated And Plaque Distant Microglia To Alzheimer’s Disease (AD) Progression

Autor: Anne-Laure Hemonnot-Girard, Catherine Rey, Joël Lachuer, Manuela Pastore, Cédric Meersseman, Nathalie Linck, Christelle Reynes, Hélène Hirbec, François Rassendren

Background: Research in recent years firmly established that microglial cells play an important role in the pathogenesis of Alzheimer's disease (AD). In parallel, a series of studies showed that, under both homeostatic and pathological conditions, mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a143f01ff70de911dd9854d8288ed6
https://doi.org/10.21203/rs.3.rs-876995/v1

Analysis of CX3CR1 haplodeficiency in male and female APPswe/PSEN1dE9 mice along Alzheimer disease progression

Autor: Audrey J. Valverde, Tangui Maurice, Charlene Delaygue, Anne-Laure Hemonnot-Girard, Jennifer Hua, Nathalie Linck, Hélène Hirbec, François Rassendren

Publikováno v: Brain, Behavior, and Immunity
Brain, Behavior, and Immunity, Elsevier, 2020, 91, pp.404-417. ⟨10.1016/j.bbi.2020.10.021⟩
Brain, Behavior, and Immunity, Elsevier, 2021, 91, pp.404-417. ⟨10.1016/j.bbi.2020.10.021⟩

International audience; Microglia, the resident immune cells of the brain, have recently emerged as key players in Alzheimer Disease (AD) pathogenesis, but their roles in AD remain largely elusive and require further investigation. Microglia function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0360ca09b20768675836f0f0303a70e
https://hal.archives-ouvertes.fr/hal-03011578

Comparative analysis of transcriptome remodeling in plaque-associated and plaque-distant microglia during amyloid-β pathology progression in mice

Autor: Anne-Laure Hemonnot-Girard, Cédric Meersseman, Manuela Pastore, Valentin Garcia, Nathalie Linck, Catherine Rey, Amine Chebbi, Freddy Jeanneteau, Stephen D. Ginsberg, Joël Lachuer, Christelle Reynes, François Rassendren, Hélène Hirbec

Publikováno v: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-26 (2022)

Abstract Background Research in recent years firmly established that microglial cells play an important role in the pathogenesis of Alzheimer's disease (AD). In parallel, a series of studies showed that, under both homeostatic and pathological condit

Externí odkaz: https://doaj.org/article/9574a05f72834460ae566069892f4b65