Comparative analysis of transcriptome remodeling in plaque-associated and plaque-distant microglia during amyloid-β pathology progression in mice

Autor: Anne-Laure Hemonnot-Girard, Cédric Meersseman, Manuela Pastore, Valentin Garcia, Nathalie Linck, Catherine Rey, Amine Chebbi, Freddy Jeanneteau, Stephen D. Ginsberg, Joël Lachuer, Christelle Reynes, François Rassendren, Hélène Hirbec

Publikováno v: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-26 (2022)

Abstract Background Research in recent years firmly established that microglial cells play an important role in the pathogenesis of Alzheimer's disease (AD). In parallel, a series of studies showed that, under both homeostatic and pathological condit

Externí odkaz: https://doaj.org/article/9574a05f72834460ae566069892f4b65

RNA Profiling of Mouse Ependymal Cells after Spinal Cord Injury Identifies the Oncostatin Pathway as a Potential Key Regulator of Spinal Cord Stem Cell Fate

Autor: Robert Chevreau, Hussein Ghazale, Chantal Ripoll, Chaima Chalfouh, Quentin Delarue, Anne Laure Hemonnot-Girard, Daria Mamaeva, Helene Hirbec, Bernard Rothhut, Shalaka Wahane, Florence Evelyne Perrin, Harun Najib Noristani, Nicolas Guerout, Jean Philippe Hugnot

Publikováno v: Cells, Vol 10, Iss 12, p 3332 (2021)

Ependymal cells reside in the adult spinal cord and display stem cell properties in vitro. They proliferate after spinal cord injury and produce neurons in lower vertebrates but predominantly astrocytes in mammals. The mechanisms underlying this glia

Externí odkaz: https://doaj.org/article/ef696616b508457b9892ce999055cce1

De nouvelles techniques pour dévoiler le rôle des cellules gliales du cerveau

Autor: Hélène Hirbec, Carole Escartin, Lucile Ben Haim, Anne-Laure Hemonnot-Girard

Publikováno v: médecine/sciences
médecine/sciences, 2021, 37 (1), pp.59-67. ⟨10.1051/medsci/2020253⟩
médecine/sciences, EDP Sciences, 2021, 37 (1), pp.59-67. ⟨10.1051/medsci/2020253⟩

Brain function relies on complex interactions between neurons and different types of glial cells, such as astrocytes, microglia and oligodendrocytes. The relatively young field of "gliobiology" is thriving. Thanks to various technical innovations, it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7285679b30dfe8d074dbcfd1ce0642
https://doi.org/10.1051/medsci/2020253

Relative Contribution of Amyloid-β Plaque Associated And Plaque Distant Microglia To Alzheimer’s Disease (AD) Progression

Autor: Anne-Laure Hemonnot-Girard, Catherine Rey, Joël Lachuer, Manuela Pastore, Cédric Meersseman, Nathalie Linck, Christelle Reynes, Hélène Hirbec, François Rassendren

Background: Research in recent years firmly established that microglial cells play an important role in the pathogenesis of Alzheimer's disease (AD). In parallel, a series of studies showed that, under both homeostatic and pathological conditions, mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a143f01ff70de911dd9854d8288ed6
https://doi.org/10.21203/rs.3.rs-876995/v1

Analysis of CX3CR1 haplodeficiency in male and female APPswe/PSEN1dE9 mice along Alzheimer disease progression

Autor: Audrey J. Valverde, Tangui Maurice, Charlene Delaygue, Anne-Laure Hemonnot-Girard, Jennifer Hua, Nathalie Linck, Hélène Hirbec, François Rassendren

Publikováno v: Brain, Behavior, and Immunity
Brain, Behavior, and Immunity, Elsevier, 2020, 91, pp.404-417. ⟨10.1016/j.bbi.2020.10.021⟩
Brain, Behavior, and Immunity, Elsevier, 2021, 91, pp.404-417. ⟨10.1016/j.bbi.2020.10.021⟩

International audience; Microglia, the resident immune cells of the brain, have recently emerged as key players in Alzheimer Disease (AD) pathogenesis, but their roles in AD remain largely elusive and require further investigation. Microglia function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0360ca09b20768675836f0f0303a70e
https://hal.archives-ouvertes.fr/hal-03011578