Výsledky vyhledávání - "Anne Laure, Huber"

Supplementary Tables from Therapeutic Enhancement of ER Stress by Insulin-Like Growth Factor I Sensitizes Myeloma Cells to Proteasomal Inhibitors

Autor: Charles Dumontet, Serge Manié, Kamel Chettab, Anne-Laure Huber, Eva-Laure Matera, Stéphanie Herveau, Lars Petter Jordheim, Inès Tagoug

PDF file - 106K, Supplemental table 1. Antibodies used in the study; Supplemental table 2. Genes differentially expressed in MM1.S cells exposed to IGF-1 (200 ng/mL) and bortezomib (10 nM). The list indicate genes with at least a 2-fold difference in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a8048f0811f4ed4c8df09f2484280f9
https://doi.org/10.1158/1078-0432.22450773.v1

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Data from Therapeutic Enhancement of ER Stress by Insulin-Like Growth Factor I Sensitizes Myeloma Cells to Proteasomal Inhibitors

Autor: Charles Dumontet, Serge Manié, Kamel Chettab, Anne-Laure Huber, Eva-Laure Matera, Stéphanie Herveau, Lars Petter Jordheim, Inès Tagoug

Purpose: Multiple myeloma is a clonal plasma cell disorder in which growth and proliferation are linked to a variety of growth factors, including insulin-like growth factor type I (IGF-I). Bortezomib, the first-in-class proteasome inhibitor, has disp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468cab445f5339e830e7545d438511e3
https://doi.org/10.1158/1078-0432.c.6522021

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Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress

Publikováno v: Life Science Alliance
Life Science Alliance, 2023, 6 (4), pp.e202201494. ⟨10.26508/lsa.202201494⟩

International audience; NLRP3 is a pattern recognition receptor with a well-documented role in inducing inflammasome assembly in response to cellular stress. Deregulation of its activity leads to many inflammatory disorders including gouty arthritis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b709990c74738977d3e066c44624153a
https://doi.org/10.26508/lsa.202201494

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Akademický článek

DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization

Autor: Stephanie J Papp, Anne-Laure Huber, Sabine D Jordan, Anna Kriebs, Madelena Nguyen, James J Moresco, John R Yates III, Katja A Lamia

Publikováno v: eLife, Vol 4 (2015)

The circadian transcriptional repressors cryptochrome 1 (Cry1) and 2 (Cry2) evolved from photolyases, bacterial light-activated DNA repair enzymes. In this study, we report that while they have lost DNA repair activity, Cry1/2 adapted to protect geno

Externí odkaz: https://doaj.org/article/0a9aa928dda64b9dac1ff996dfe76662

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The circadian E3 ligase complex SCFFBXL3+CRY targets TLK2

Autor: John R. Yates, Norjin Zolboot, Megan Vaughan, Katja A. Lamia, Valerie Perea, Stephanie Papp Correia, Alanna B. Chan, Anna Kriebs, James J. Moresco, Anne Laure Huber

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)

We recently demonstrated that the circadian clock component CRY2 is an essential cofactor in the SCFFBXL3-mediated ubiquitination of c-MYC. Because our demonstration that CRY2 recruits phosphorylated substrates to SCFFBXL3 was unexpected, we investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7813aac4e22da664dce94991c0591e51
http://link.springer.com/article/10.1038/s41598-018-36618-3

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NLRP3 controls ATM activation in response to DNA damage

Autor: Nadege Goutagny, Sylvie Lantuejoul, Sabine Hacot, Yohann Couté, Benedicte F. Py, Elise Ballot, Annabelle Ballesta, Laetitia Gerossier, Virginie Pétrilli, Baptiste Guey, Janet E. Hall, Birke Bartosch, François Ghiringhelli, Julie Gorry, Mélanie Bodnar-Wachtel, Anne-Laure Huber

Publikováno v: bioRxiv
BioRxiv

The DNA damage response (DDR) is essential to preserve genomic integrity and acts as abarrier to cancer. The ATM pathway orchestrates the cellular response to DNA double strandbreaks (DSBs), and its attenuation is frequent during tumorigenesis. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2194518eb798b324f486dfed7f72ab00
https://hal.science/hal-03093041/document

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Akademický článek

Pdro, a protein associated with late endosomes and lysosomes and implicated in cellular cholesterol homeostasis.

Autor: Patricia Guillaumot, Céline Luquain, Mouhannad Malek, Anne-Laure Huber, Sabine Brugière, Jérome Garin, Didier Grunwald, Daniel Régnier, Virginie Pétrilli, Etienne Lefai, Serge N Manié

Publikováno v: PLoS ONE, Vol 5, Iss 6, p e10977 (2010)

BACKGROUND: Cellular cholesterol is a vital component of the cell membrane. Its concentration is tightly controlled by mechanisms that remain only partially characterized. In this study, we describe a late endosome/lysosomes-associated protein whose

Externí odkaz: https://doaj.org/article/5cb58bc3fa154c9db2845b192e031dc0

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The Liver Circadian Clock Modulates Biochemical and Physiological Responses to Metformin

Autor: Drew Duglan, Erin Soto, Katja A. Lamia, Megan E. Afetian, Anne Laure Huber, Megan Vaughan, Anna Kriebs, Madelena Nguyen, Emma Henriksson, Stephanie J. Papp, Alanna B. Chan

Publikováno v: Journal of Biological Rhythms. 32:345-358

Metformin is widely used in the treatment of type 2 diabetes to lower blood glucose. Although metformin is a relatively safe and effective drug, its clinical efficacy is variable and under certain circumstances it may contribute to life-threatening l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ec3d9a6859b55c94c9202a195b505b
https://doi.org/10.1177/0748730417710348

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