Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Anne Landsem"'
Autor:
Anne Landsem, Åse Emblem, Corinna Lau, Dorte Christiansen, Alexandra Gerogianni, Bård Ove Karlsen, Tom Eirik Mollnes, Per H. Nilsson, Ole-Lars Brekke
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionPlatelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis
Externí odkaz:
https://doaj.org/article/0679ee2f1ecd4d07aa04f0face1e0719
Autor:
Benjamin S. Storm, Judith K. Ludviksen, Dorte Christiansen, Hilde Fure, Kristin Pettersen, Anne Landsem, Bent Aksel Nilsen, Knut Dybwik, Tonje Braaten, Erik W. Nielsen, Tom E. Mollnes
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionAir embolism may complicate invasive medical procedures. Bubbles trigger complement C3-mediated cytokine release, coagulation, and platelet activation in vitro in human whole blood. Since these findings have not been verified in vivo, we
Externí odkaz:
https://doaj.org/article/c0cd82a4cd91431ba31d6494add12eda
Autor:
Elin Storjord, Stella Airila-Månsson, Katarzyna Karlsen, Martin Madsen, Jim André Dahl, Anne Landsem, Hilde Fure, Judith Krey Ludviksen, Johannes Østrem Fjøse, Amy K. Dickey, Bård Ove Karlsen, Erik Waage Nielsen, Tom Eirik Mollnes, Ole-Lars Brekke
Publikováno v:
Life, Vol 12, Iss 8, p 1270 (2022)
In the inherited metabolic disorder acute intermittent porphyria (AIP), high sugar intake prevents porphyric attacks due to the glucose effect and the following high insulin levels that may lower AIP disease activity. Insulin resistance is a known ri
Externí odkaz:
https://doaj.org/article/5fef6f71f47042a78d11f5916cd4ef31
Autor:
Dorte Christiansen, Grethe Bergseth, S. Nymo, Terje Espevik, Tom Eirik Mollnes, Knut Tore Lappegård, J. Krey Ludviksen, Ole-Lars Brekke, Trent M. Woodruff, Anne Landsem, Hilde Fure, Corinna Lau, M. Mathisen
Publikováno v:
Clinical and Experimental Immunology
There is a close cross‐talk between complement, Toll‐like receptors (TLRs) and coagulation. The role of the central complement component 5 (C5) in physiological and pathophysiological hemostasis has not, however, been fully elucidated. This study
Autor:
Jean M. H. van den Elsen, Camilla Schjalm, Ole-Lars Brekke, Tom Eirik Mollnes, Soeren Erik Pischke, Grethe Bergseth, Oliver Durrant, Linda M. Haugaard-Kedström, Anne Landsem, Alex Macpherson, Quang Huy Quach, Per H. Nilsson, Hilde Fure, Markus Huber-Lang, Christina Johnson
Publikováno v:
J Immunol
Journal of Immunology
Nilsson, P H, Johnson, C, Quach, Q H, Macpherson, A, Durrant, O, Pischke, S E, Fure, H, Landsem, A, Bergseth, G, Schjalm, C, Haugaard-Kedström, L M, Huber-Lang, M, van den Elsen, J, Brekke, O L & Mollnes, T E 2021, ' A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity ', Journal of Immunology, vol. 207, no. 6, pp. 1641-1651 . https://doi.org/10.4049/jimmunol.2001471
Journal of Immunology
Nilsson, P H, Johnson, C, Quach, Q H, Macpherson, A, Durrant, O, Pischke, S E, Fure, H, Landsem, A, Bergseth, G, Schjalm, C, Haugaard-Kedström, L M, Huber-Lang, M, van den Elsen, J, Brekke, O L & Mollnes, T E 2021, ' A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity ', Journal of Immunology, vol. 207, no. 6, pp. 1641-1651 . https://doi.org/10.4049/jimmunol.2001471
Thrombin activation of C5 connects thrombosis to inflammation. Complement research in whole blood ex vivo necessitates anticoagulation, which potentially interferes with the inflammatory modulation by thrombin. We challenged the concept of thrombin a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b448dc19a64a17108672b963fe184bed
http://hdl.handle.net/10852/88977
http://hdl.handle.net/10852/88977
Autor:
Anne Landsem, Tom Eirik Mollnes, Jim André Dahl, Bård Ove Karlsen, Judith K Ludviksen, Erik Waage Nielsen, S. Goldbeck‐Wood, Hilde Fure, Ole-Lars Brekke, Elin Storjord, K. S. Berg
Publikováno v:
Clinical and Experimental Immunology. 187:466-479
Summary This study aimed to examine whether acute intermittent porphyria (AIP) is associated with systemic inflammation and whether the inflammation correlates with disease activity. A case–control study with 50 AIP cases and age-, sex- and place o
Autor:
Anne Mari Rokstad, Bente Halvorsen, Terje Espevik, Eva A. Jacobsen, Tom Eirik Mollnes, Bjørg Steinkjer, Caroline S. Gravastrand, John D. Lambris, Ole-Lars Brekke, Mona Skjelland, Anne Landsem, Trent M. Woodruff
Publikováno v:
Journal of Immunology
Cholesterol crystals (CC) are strong activators of complement and could potentially be involved in thromboinflammation through complement-coagulation cross-talk. To explore the coagulation-inducing potential of CC, we performed studies in lepirudin-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6bd85f115d783d86a6f5835d8cb162
https://hdl.handle.net/10037/18298
https://hdl.handle.net/10037/18298
Autor:
Anne Landsem, Terje Espevik, Dorte Christiansen, Jørgen Stenvik, Espen Waage Skjeflo, Tom Eirik Mollnes, Trent M. Woodruff, Erik Waage Nielsen
Publikováno v:
Molecular Immunology
Source at https://doi.org/10.1016/j.molimm.2019.03.014. Background - Sepsis is a dysregulated host response to infection. The aim of this study was to investigate the effects of complement- and CD14 inhibition on phagocytosis of live and dead Gram-ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64783421b8b0df80a2e5a8697559eef4
http://hdl.handle.net/11250/2632033
http://hdl.handle.net/11250/2632033
Autor:
Jim André Dahl, Bård Ove Karlsen, Anne Landsem, Judith K Ludviksen, Elin Storjord, Ole-Lars Brekke, Marlene Karlsen
Background Lifestyle factors, including a low intake of carbohydrates, dieting, alcohol consumption, cigarette smoking and stress are some of the possible triggers of attacks in acute intermittent porphyria (AIP). The influence of lifestyle factors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ebac6b83f11147d996040581377ea4
https://hdl.handle.net/10037/15306
https://hdl.handle.net/10037/15306
Autor:
Dorte Christiansen, Søren Erik Pischke, Anne Landsem, Terje Espevik, Tom Eirik Mollnes, John D. Lambris, Alice Gustavsen, Corinna Lau, Liv Ryan, Harald Husebye, Stig Haugset Nymo
Publikováno v:
The Journal of Infectious Diseases
Journal of Infectious Diseases
Journal of Infectious Diseases
Background. Single inhibition of the Toll-like receptor 4 (TLR4)–MD2 complex failed in treatment of sepsis. CD14 is a coreceptor for several TLRs, including TLR4 and TLR2. The aim of this study was to investigate the effect of single TLR4-MD2 inhib