Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Anne L. Thielke"'
Autor:
Fei Chang, Camilla Gunderstofte, Nicole Colussi, Mareena Pitts, Sonia R. Salvatore, Anne L. Thielke, Lucia Turell, Beatriz Alvarez, Raphaela Goldbach-Mansky, Luis Villacorta, Christian K. Holm, Francisco J. Schopfer, Anne Louise Hansen
Publikováno v:
Redox Biology, Vol 74, Iss , Pp 103202- (2024)
Stimulator of Interferon Genes (STING) is essential for the inflammatory response to cytosolic DNA. Despite that aberrant activation of STING is linked to an increasing number of inflammatory diseases, the development of inhibitors has been challengi
Externí odkaz:
https://doaj.org/article/cf3a9eefd90d46eca97eb23c61fe9d7d
Autor:
David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E. Jørgensen, Michelle Thomsen, Line S. Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H. Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G. Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Jakobsen, Esben B. Svenningsen, Thomas B. Poulsen, Lydia Bartsch, Anne L. Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcamí, John Hiscott, Trine H. Mogensen, Søren R. Paludan, Christian K. Holm
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Viral infections usually cause disease through direct cytopathogenic effects and excessive inflammatory responses. Here, Olagnier et al. show that two NRF2 agonists, 4-OI and DMF, possess broad IFN-independent antiviral activity and decrease host inf
Externí odkaz:
https://doaj.org/article/7eb1ed3741cc4fbfa366937b0037cc35
Autor:
David Olagnier, Aske M. Brandtoft, Camilla Gunderstofte, Nikolaj L. Villadsen, Christian Krapp, Anne L. Thielke, Anders Laustsen, Suraj Peri, Anne Louise Hansen, Lene Bonefeld, Jacob Thyrsted, Victor Bruun, Marie B. Iversen, Lin Lin, Virginia M. Artegoitia, Chenhe Su, Long Yang, Rongtuan Lin, Siddharth Balachandran, Yonglun Luo, Mette Nyegaard, Bernadette Marrero, Raphaela Goldbach-Mansky, Mona Motwani, Dylan G. Ryan, Katherine A. Fitzgerald, Luke A. O’Neill, Anne K. Hollensen, Christian K. Damgaard, Frank v. de Paoli, Hanne C. Bertram, Martin R. Jakobsen, Thomas B. Poulsen, Christian K. Holm
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Understanding how regulators of inflammation affect nucleic acid sensing is important for targeting research against inflammatory diseases and conditions. Here, the authors identify Nrf2 as an important negative regulator of STING and suggest a link
Externí odkaz:
https://doaj.org/article/5fc54bf6fbd8427c94401b47231854b6
Autor:
David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E. Jørgensen, Michelle Thomsen, Line S. Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H. Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G. Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Jakobsen, Esben B. Svenningsen, Thomas B. Poulsen, Lydia Bartsch, Anne L. Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcamí, John Hiscott, Trine H. Mogensen, Søren R. Paludan, Christian K. Holm
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/7a767ab0a50943a0a5a6e85eaa10ccfe
Autor:
Christian K. Holm, Anne L. Thielke, Rasmus Ottosen, Thomas B. Poulsen, Jinrong Huang, Alice Knudsen, Lydia Bartsch, Siddharth Balachandran, Marie B. Iversen, Camilla G. Nielsen, Victoria H. Gilchrist, Trine H. Mogensen, Huy-Dung Hoang, Alon Schneider Hait, Sofie E. Jørgensen, Line S. Reinert, Suraj Peri, Jan Rehwinkel, Michael Lappe, Charlotte Möller, Michelle M. Thomsen, John Hiscott, Demi van der Horst, Esben B. Svenningsen, Anne Louise Hansen, Yonglun Luo, Jacob Thyrsted, Manja Idorn, Antonio Alcami, Ensieh Farahani, Julia Blay-Cadanet, Martin R. Jakobsen, Bruno Hernáez, Mirjam Schilling, David Olagnier, Søren R. Paludan, Angela Herengt, Tommy Alain
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Olagnier, D, Farahani, E, Thyrsted, J, Blay-Cadanet, J, Herengt, A, Idorn, M, Hait, A, Hernaez, B, Knudsen, A, Iversen, M B, Schilling, M, Jørgensen, S E, Thomsen, M, Reinert, L S, Lappe, M, Hoang, H-D, Gilchrist, V H, Hansen, A L, Ottosen, R, Nielsen, C G, Møller, C, van der Horst, D, Peri, S, Balachandran, S, Huang, J, Jakobsen, M, Svenningsen, E B, Poulsen, T B, Bartsch, L, Thielke, A L, Luo, Y, Alain, T, Rehwinkel, J, Alcamí, A, Hiscott, J, Mogensen, T H, Paludan, S R & Holm, C K 2020, ' SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate ', Nature Communications, vol. 11, no. 1, 4938 . https://doi.org/10.1038/s41467-020-18764-3
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Olagnier, D P C, Farahani, E, Jensen, J T, Blay Cadanet, J, Herengt, A A P V, Idorn, M, Schneider Hait, A I, Hernaez, B, Knudsen, A, Iversen, M B, Schilling, M, Jørgensen, S E, Thomsen, M M, Reinert, L S, Lappe, M, Hoang, H D, Gilchrist, V H, Hansen, A L, Ottosen, R, Nielsen, C G, Møller, C, van der Horst, D, Peri, S, Balachandran, S, Huang, J, Jakobsen, M, Svenningsen, E B, Poulsen, T B, Bartsch, L, Thielke, A L, Luo, Y, Alain, T, Rehwinkel, J, Alcamí, A, Hiscott, J, Mogensen, T H, Paludan, S R & Holm, C K 2020, ' SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate ', Nature Communications, vol. 11, 4938 . https://doi.org/10.1038/s41467-020-18764-3
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Olagnier, D, Farahani, E, Thyrsted, J, Blay-Cadanet, J, Herengt, A, Idorn, M, Hait, A, Hernaez, B, Knudsen, A, Iversen, M B, Schilling, M, Jørgensen, S E, Thomsen, M, Reinert, L S, Lappe, M, Hoang, H-D, Gilchrist, V H, Hansen, A L, Ottosen, R, Nielsen, C G, Møller, C, van der Horst, D, Peri, S, Balachandran, S, Huang, J, Jakobsen, M, Svenningsen, E B, Poulsen, T B, Bartsch, L, Thielke, A L, Luo, Y, Alain, T, Rehwinkel, J, Alcamí, A, Hiscott, J, Mogensen, T H, Paludan, S R & Holm, C K 2020, ' SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate ', Nature Communications, vol. 11, no. 1, 4938 . https://doi.org/10.1038/s41467-020-18764-3
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Olagnier, D P C, Farahani, E, Jensen, J T, Blay Cadanet, J, Herengt, A A P V, Idorn, M, Schneider Hait, A I, Hernaez, B, Knudsen, A, Iversen, M B, Schilling, M, Jørgensen, S E, Thomsen, M M, Reinert, L S, Lappe, M, Hoang, H D, Gilchrist, V H, Hansen, A L, Ottosen, R, Nielsen, C G, Møller, C, van der Horst, D, Peri, S, Balachandran, S, Huang, J, Jakobsen, M, Svenningsen, E B, Poulsen, T B, Bartsch, L, Thielke, A L, Luo, Y, Alain, T, Rehwinkel, J, Alcamí, A, Hiscott, J, Mogensen, T H, Paludan, S R & Holm, C K 2020, ' SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate ', Nature Communications, vol. 11, 4938 . https://doi.org/10.1038/s41467-020-18764-3
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Versiones preprint disponibles en: http://hdl.handle.net/10261/216920 y http://hdl.handle.net/10261/217161
Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 ar
Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 ar
Autor:
Stefania Crotta, Christian K. Holm, Anne L. Thielke, Alexander Heinz, Julia Blay-Cadanet, Jacob Thyrsted, Karsten Hiller, Anne Louise Hansen, David Olagnier, Andreas Wack, Jacob Storgaard, Frank Vincenzo de Paoli
Publikováno v:
iScience
Aarhus University
Thyrsted, J, Storgaard, J, Blay Cadanet, J, Heinz, A, Thielke, A L, Crotta, S, de Paoli, F V, Olagnier, D P C, Wack, A, Hiller, K, Hansen, A L & Holm, C K 2021, ' Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium ', iScience .
Thyrsted, J, Storgaard, J, Blay-Cadanet, J, Heinz, A, Thielke, A L, Crotta, S, de Paoli, F, Olagnier, D, Wack, A, Hiller, K, Hansen, A L & Holm, C K 2021, ' Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium ', iScience, vol. 24, no. 11, pp. 103300 . https://doi.org/10.1016/j.isci.2021.103300
iScience, Vol 24, Iss 11, Pp 103300-(2021)
Aarhus University
Thyrsted, J, Storgaard, J, Blay Cadanet, J, Heinz, A, Thielke, A L, Crotta, S, de Paoli, F V, Olagnier, D P C, Wack, A, Hiller, K, Hansen, A L & Holm, C K 2021, ' Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium ', iScience .
Thyrsted, J, Storgaard, J, Blay-Cadanet, J, Heinz, A, Thielke, A L, Crotta, S, de Paoli, F, Olagnier, D, Wack, A, Hiller, K, Hansen, A L & Holm, C K 2021, ' Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium ', iScience, vol. 24, no. 11, pp. 103300 . https://doi.org/10.1016/j.isci.2021.103300
iScience, Vol 24, Iss 11, Pp 103300-(2021)
Summary Pathogenic viruses induce metabolic changes in host cells to secure the availability of biomolecules and energy to propagate. Influenza A virus (IAV) and severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) both infect the human airw
Autor:
Andreas Wack, Christian K. Holm, Julia Blay-Cadanet, Stefania Crotta, Jacob Thyrsted, David Olagnier, Karsten Hiller, Jacob Storgaard, Anne Louise Hansen, Anne L. Thielke, Frank Vincenzo de Paoli, Alexander Heinz
Publikováno v:
SSRN Electronic Journal.
Pathogenic viruses induce metabolic changes in host cells to secure availability of biomolecules and energy to propagate. Influenza A virus and SARS-CoV-2 both infect the human airway epithelium and are important human pathogens. The metabolic change
Autor:
Jinrong Huang, Demi van der Horst, Lydia Bartsch, Marie B. Iversen, Line S. Reinert, Camilla Gunderstofte, Esben B. Svenningsen, Anne Louise Hansen, Anne L. Thielke, Tommy Alain, Bruno Hernáez, Huy-Dung Hoang, John Hiscott, Thomas B. Poulsen, Charlotte Möller, Julia Blay Cadanet, Sofie E. Jørgensen, Christian K. Holm, Michael Lappe, Alon Schneider Hait, Jan Rehwinkel, Yonglun Luo, Jacob Thyrsted, Martin R. Jakobsen, Rasmus Ottosen, Michelle M. Thomsen, Søren R. Paludan, Manja Idorn, Antonio Alcami, Suraj Peri, Ensieh Farahani, Angela Herengt, Mirjam Schilling, David Olagnier, Trine H. Mogensen, Alice Knudsen, Siddharth Balachandran, Victoria H. Gilchrist
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 are urgently required. Here we demonstrate that the NRF2 anti-oxidant gene expression pathway is suppressed in bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78d0c8a4ddfb8c2f90f5fcc79fbd2a4
https://doi.org/10.1101/2020.07.16.206458
https://doi.org/10.1101/2020.07.16.206458
Autor:
Aske M Brandtoft, David Olagnier, Christian K. Holm, Mette Nyegaard, Anne L. Thielke, Anne Louise Hansen
Publikováno v:
Hansen, A L, Brandtoft, A M, Nyegaard, M, Thielke, A L, Olagnier, D & Holm, C K 2018, ' Global transcriptional changes in response to cGAMP depend on STING in human THP-1 cells ', Cellular & molecular immunology, vol. 15, pp. 983-985 . https://doi.org/10.1038/s41423-018-0035-x
Autor:
Marie B. Iversen, Siddharth Balachandran, Camilla Gunderstofte, Christian K. Holm, David Olagnier, Anne L. Thielke, Suraj Peri
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Gunderstofte, C, Iversen, M B, Peri, S, Thielke, A, Balachandran, S, Holm, C K & Olagnier, D 2019, ' Nrf2 Negatively Regulates Type I Interferon Responses and Increases Susceptibility to Herpes Genital Infection in Mice ', Frontiers in Immunology, vol. 10, 2101 . https://doi.org/10.3389/fimmu.2019.02101
Frontiers in Immunology
Gunderstofte, C, Iversen, M B, Peri, S, Thielke, A, Balachandran, S, Holm, C K & Olagnier, D 2019, ' Nrf2 Negatively Regulates Type I Interferon Responses and Increases Susceptibility to Herpes Genital Infection in Mice ', Frontiers in Immunology, vol. 10, 2101 . https://doi.org/10.3389/fimmu.2019.02101
Frontiers in Immunology
Herpes simplex virus-2 (HSV-2) is a leading cause of sexually transmitted infections for which no effective vaccines or prophylactic treatment currently exist. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor involved in t