Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Anne L. Killam"'
Autor:
Xin-Jun Liu, Yinghong Gao, Zhiqiang Guo, Martin W. Rowbottom, Timothy D. Gross, Anne L Killam Bonneville, Acevedo O, Caroline W. Chen, Struthers Rs, Haig Bozigian, Greg J. Reinhart, Ta-Kung Chen, Fabio C. Tucci, Nicholas Ling, John Saunders, Qui Xie, Yun-Fei Zhu
Publikováno v:
Journal of Medicinal Chemistry. 48:1169-1178
Further structure-activity relationship studies of a series of substituted uracils at the 1, 3, and 5 positions resulted in the discovery of several potent antagonists of the human gonadotropin-releasing hormone receptor. Uracils bearing a side chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87529259eebd56ca0c42b5b5375da127
https://doi.org/10.1021/jm049218c
https://doi.org/10.1021/jm049218c
Autor:
Patrick J. Connors, Liping Jin, Haig Bozigian, Timothy D. Gross, Fabio C. Tucci, Ta Kung Chen, R. Scott Struthers, Chen Chen, Greg J. Reinhart, John Saunders, Qiu Xie, Martin W. Rowbottom, Yinghong Gao, Zhiqiang Guo, Anne L Killam Bonneville, Andrew Fisher, Yun-Fei Zhu
Publikováno v:
Journal of Medicinal Chemistry. 47:3483-3486
Uracils possessing N-3 side chains derived from various amino alcohols were designed and synthesized as potent human gonadotropin releasing hormone receptor antagonists. The compounds herein presented displayed superior metabolic stability than their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a763114ebf99451c3177008485abea
https://doi.org/10.1021/jm049791w
https://doi.org/10.1021/jm049791w
Autor:
Julie K. Doerr Stevens, Yigal Greener, Harald Becher, Anne L. Killam, Sheila Podell, Klaus Tiemann, Teri Kuvelas, Howard C. Dittrich, Jon Goenechea, Jeffrey John Miller
Publikováno v:
Journal of the American Society of Echocardiography. 12:1027-1034
Traditionally, performing myocardial contrast echocardiography with OPTISON required maximal bolus dosing. However, sustained and consistent opacification of the myocardium would be preferable for perfusion imaging. Methods: Images of 5 anesthetized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd7a4ec181796ee888d9aa2a20b5ed4
https://doi.org/10.1016/s0894-7317(99)70098-2
https://doi.org/10.1016/s0894-7317(99)70098-2
Autor:
Paul A. Zavorskas, Britta A. McFerran, Howard C. Dittrich, Edward G. Jablonski, Leslie Anderson, Anne L. Killam, Paige M. Mehlhaff, Jeffrey John Miller, Yigal Greener, Cindy Burrascano
Publikováno v:
International Journal of Toxicology. 18:49-63
OPTISON, an agent being developed as an intravenous (IV) ultrasound contrast agent, consists of a suspension of octafluoro-propane(OFP)-containing albumin microspheres. The distribution and elimination of the albumin component and the elimination kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16819757cf007eae035f8020a785c329
https://doi.org/10.1080/109158199225800
https://doi.org/10.1080/109158199225800
Publikováno v:
International Journal of Toxicology. 17:631-662
OPTISON (FS069), an ultrasonic diagnostic contrast agent, is a suspension of perfluoropropane (PFP)-filled album in microspheres of 2.0-4.5 microns average diameter and 5.0-8.O x 108 microspheresl ml. The following non clinical safety assessment stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bed1409a0b069c50c61e2861af95f891
https://doi.org/10.1080/109158198225892
https://doi.org/10.1080/109158198225892
Autor:
Anne L. Killam
Publikováno v:
Hematology/Oncology Clinics of North America. 7:1143-1151
After decades of focus on the effects of cocaine abuse on the central nervous system (CNS), the cardiovascular toxicity of cocaine is just beginning to be appreciated. The most common cardiovascular pathologies associated with cocaine use include: ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bf256bd37bb13236594eed9a9a05054
https://doi.org/10.1016/s0889-8588(18)30203-x
https://doi.org/10.1016/s0889-8588(18)30203-x
Publikováno v:
Thrombosis and Haemostasis. 66:355-360
SummaryThe present study was designed to evaluate the effectiveness of the ergoline 5HT2 receptor antagonist, LY53857 in a rabbit model of vascular arterial occlusion. LY53857 (1 and 10 εM) inhibited serotonin amplified platelet aggregation response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21a734e7a04ab2b8b54a4f0b90fb725c
https://doi.org/10.1055/s-0038-1646420
https://doi.org/10.1055/s-0038-1646420
Autor:
Greg J. Reinhart, Ta-Kung Chen, Trudy A. Kohout, R. Scott Struthers, Haig Bozigian, Anne L Killam Bonneville, Chen Chen, Qui Xie, Susan K. Sullivan, Weidong Yang, Yun-Fei Zhu, Xin-Jun Liu, Nicholas Ling, Richard A. Maki
Publikováno v:
Endocrinology. 148(2)
Suppression of the hypothalamic-pituitary-gonadal axis by peptides that act at the GnRH receptor has found widespread use in clinical practice for the management of sex-steroid-dependent diseases (such as prostate cancer and endometriosis) and reprod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12695b92817331b283ba628d8cd202b6
https://pubmed.ncbi.nlm.nih.gov/17095587
https://pubmed.ncbi.nlm.nih.gov/17095587
Autor:
Patrick J. Connors, Greg J. Reinhart, Ta Kung Chen, Yinghong Gao, Chen Chen, Fabio C. Tucci, Yongsheng Chen, Zhiqiang Guo, and Anne L. Killam Bonneville, John Saunders, Qiu Xie, Yun-Fei Zhu, R. Scott Struthers, Manisha Moorjani, Timothy D. Gross, Martin W. Rowbottom
Publikováno v:
Journal of medicinal chemistry. 47(5)
Based on the SAR from bicyclic gonadotropin-releasing hormone (GnRH) antagonists such as 6-aminomethyl-7-aryl-pyrrolo[1,2-a]pyrimid-4-ones (5) and 2-aryl-3-aminomethyl-imidazolo[1,2-a]pyrimid-5-ones (6a,b), a series of novel uracil compounds (8) were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e3ad1f0157cc8d81d313b17dfd4357
https://pubmed.ncbi.nlm.nih.gov/14971906
https://pubmed.ncbi.nlm.nih.gov/14971906
Autor:
Yigal Greener, Makoto Suematsu, Geert W. Schmid-Schönbein, Edward G. Jablonski, Anne L. Killam, Shinichiro J. Tojo, Takanori Yasu, Shunichi Fukuda
Publikováno v:
International journal of cardiology. 98(2)
To characterize the flow dynamics of albumin ultrasound contrast microspheres containing perfluoropropane (PFP) in normal and inflamed microvasculature.Mesenteric microvessels of rats were examined after an intravenous injection of fluorocein-labeled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702348fd0417cec52b6518757209fedb
https://pubmed.ncbi.nlm.nih.gov/15686774
https://pubmed.ncbi.nlm.nih.gov/15686774