Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Anne L. Crews"'
Autor:
Shijing Fang, Joungjoa Park, Qi Yin, Kenneth B. Adler, Anne L. Crews, Indu Parikh, Brian Dickson, Mary Katherine Sheats
Publikováno v:
American journal of respiratory cell and molecular biology. 60(1)
MARCKS (myristoylated alanine-rich C kinase substrate) is a prominent PKC substrate expressed in all eukaryotic cells. It is known to bind to and cross-link actin filaments, to serve as a bridge between Ca(2+)/calmodulin and PKC signaling, and to seq
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 304:L511-L518
Myristoylated alanine-rich C kinase substrate (MARCKS) protein has been recognized as a key regulatory molecule controlling mucin secretion by airway epithelial cells in vitro and in vivo. We recently showed that two intracellular chaperones, heat sh
Publikováno v:
Open Journal of Respiratory Diseases. :89-96
Hypersecretion of mucus characterizes many inflammatory airway diseases, including asthma, chronic bronchitis, and cystic fibrosis. Excess mucus causes airway obstruction, reduces pulmonary function, and can lead to increased morbidity and mortality.
Publikováno v:
American journal of respiratory cell and molecular biology. 55(5)
Intratracheal instillation of bacterial LPS is a well-established model of acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). Because the myristoylated alanine-rich C kinase substrate (MARCKS) protein is involved in neutrophil
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1810:1110-1113
Background A major characteristic of asthmatic airways is an increase in mucin (the glycoprotein component of mucus) producing and secreting cells, which leads to increased mucin release that further clogs constricted airways and contributes markedly
Autor:
Janet Talbert, Anastasia L. Wise, James E. Loyd, Ivana V. Yang, Kenneth B. Adler, Marvin I. Schwarz, Roland M. du Bois, Kevin K. Brown, Christopher M. Evans, Steve D. Groshong, Corinne E. Hennessy, Michelle G. Roy, Anne L. Crews, Joungjoa Park, David A. Schwartz, Susan Slifer, Max A. Seibold, Mark P. Steele, Gunnar Gudmundsson, Aretha Herron, Marcy C. Speer, Tasha E. Fingerlin, Burton F. Dickey, Stavros Garantziotis, Cheryl Markin, Scott S. Auerbach, Jia Lin, Weiming Zhang, Dolly Kervitsky
Publikováno v:
New England Journal of Medicine. 364:1503-1512
A b s t r ac t Background The mutations that have been implicated in pulmonary fibrosis account for only a small proportion of the population risk. Methods Using a genomewide linkage scan, we detected linkage between idiopathic interstitial pneumonia
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 43:131-136
We have shown previously that myristoylated alanine-rich C kinase substrate (MARCKS) is a key regulatory molecule in the process of mucin secretion by airway epithelial cells, and that part of the secretory mechanism involves intracellular associatio
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 39:68-76
We have reported previously that myristoylated alanine-rich C kinase substrate (MARCKS) is a key regulatory molecule controlling mucin secretion by airway epithelial cells in vitro and in vivo. The results of those studies supported a mechanism where
Autor:
Jennifer L. Ingram, Monica Kraft, Anne L. Crews, Kenneth B. Adler, D. C. Krause, Charles B. Cairns, T. P. Atkinson, Hong Wei Chu
Publikováno v:
European Respiratory Journal. 31:43-46
As excess mucin expression can contribute to the exacerbation of asthma, the present authors hypothesised that Mycoplasma pneumoniae significantly induces MUC5AC (the major airway mucin) expression in airway epithelial cells isolated directly from as
Publikováno v:
Journal of Clinical Oncology. 35:e23017-e23017
e23017 Background: We have previously reported that administration of peptides that inhibit the function of MARCKS (myristoylated alanine-rich C Kinase Substrate) inhibit metastasis of human lung cancer cells orthotopically-injected into the left lun