Výsledky vyhledávání - "Anne L. Ashford"

Akademický článek

DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome

Autor: Sònia Najas, Juan Arranz, Pamela A. Lochhead, Anne L. Ashford, David Oxley, Jean M. Delabar, Simon J. Cook, María José Barallobre, Maria L. Arbonés

Publikováno v: EBioMedicine, Vol 2, Iss 2, Pp 120-134 (2015)

Alterations in cerebral cortex connectivity lead to intellectual disability and in Down syndrome, this is associated with a deficit in cortical neurons that arises during prenatal development. However, the pathogenic mechanisms that cause this defici

Externí odkaz: https://doaj.org/article/2e2616fe74d7438690f9863488a1d0a7

Zobrazit plný text záznamu

Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome

Autor: Kevin Hudson, Pamela A. Lochhead, Raffaella Gallo, Rachel Rowlinson, Mark Cockerill, Sylvie Guichard, Kathryn Balmanno, Richard A. Ward, Lisa M. Baak, Anne L. Ashford, Simon J. Cook, Tom Dunkley, Louise Goodwin

Publikováno v: Cellular and Molecular Life Sciences

The dual-specificity tyrosine-phosphorylation-regulated kinase, DYRK1B, is expressed de novo during myogenesis, amplified or mutated in certain cancers and mutated in familial cases of metabolic syndrome. DYRK1B is activated by cis auto-phosphorylati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c57d3f6de14c16894ea84a1d3bcc0a
https://doi.org/10.1007/s00018-015-2032-x

Zobrazit plný text záznamu

A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288)

Autor: Sylvie Guichard, Jason Grant Kettle, Kevin Hudson, David Oxley, Anne L. Ashford, Simon J. Cook, Pamela A. Lochhead

Publikováno v: The Biochemical journal. 457(1)

DYRK1B (dual-specificity tyrosine phosphorylation-regulated kinase 1B) is amplified in certain cancers and may be an oncogene; however, our knowledge of DYRK1B has been limited by the lack of selective inhibitors. In the present study we describe AZ1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2325341080ba6bfdf3df60ae91c3f39
https://pubmed.ncbi.nlm.nih.gov/24134204

Zobrazit plný text záznamu

DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome

Autor: David Oxley, Maria L. Arbonés, Pamela A. Lochhead, Anne L. Ashford, Maria Jose Barallobre, Juan Arranz, Sonia Najas, Jean M. Delabar, Simon J. Cook

Publikováno v: EBioMedicine, Vol 2, Iss 2, Pp 120-134 (2015)
EBioMedicine
Digital.CSIC. Repositorio Institucional del CSIC
instname

© 2015. Alterations in cerebral cortex connectivity lead to intellectual disability and in Down syndrome, this is associated with a deficit in cortical neurons that arises during prenatal development. However, the pathogenic mechanisms that cause th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8157959e7f566763d11e282160e94a

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání