Outstanding outcomes with two low intensity regimens in children with low-risk B-ALL: a report from COG AALL0932

Autor: Reuven J. Schore, Anne L. Angiolillo, John A. Kairalla, Meenakshi Devidas, Karen R. Rabin, Patrick Zweidler-McKay, Michael J. Borowitz, Brent Wood, Andrew J. Carroll, Nyla A. Heerema, Mary V. Relling, Johann Hitzler, Nina S. Kadan-Lottick, Kelly Maloney, Cindy Wang, William L. Carroll, Naomi J. Winick, Elizabeth A. Raetz, Mignon L. Loh, Stephen P. Hunger

Publikováno v: Leukemia.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ddfa816e82ca18b31e4973ca2be53ae
https://doi.org/10.1038/s41375-023-01870-8

Persistence of Chemotherapy-Induced Peripheral Neuropathy Despite Vincristine Reduction in Childhood B-Acute Lymphoblastic Leukemia

Autor: Rozalyn L Rodwin, John A Kairalla, Emily Hibbitts, Meenakshi Devidas, Moira K Whitley, Caroline E Mohrmann, Reuven J Schore, Elizabeth Raetz, Naomi J Winick, Stephen P Hunger, Mignon L Loh, Marilyn J Hockenberry, Anne L Angiolillo, Kirsten K Ness, Nina S Kadan-Lottick

Publikováno v: J Natl Cancer Inst

Background Children with B-acute lymphoblastic leukemia (B-ALL) are at risk for chemotherapy-induced peripheral neuropathy (CIPN). Children’s Oncology Group AALL0932 randomized reduction in vincristine and dexamethasone (every 4 weeks vs 12 weeks d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8b0e9b3e07f1cd941db9be7c358d38
https://pubmed.ncbi.nlm.nih.gov/35552709

The genomic landscape of pediatric acute lymphoblastic leukemia

Autor: Samuel W. Brady, Kathryn G. Roberts, Zhaohui Gu, Lei Shi, Stanley Pounds, Deqing Pei, Cheng Cheng, Yunfeng Dai, Meenakshi Devidas, Chunxu Qu, Ashley N. Hill, Debbie Payne-Turner, Xiaotu Ma, Ilaria Iacobucci, Pradyuamna Baviskar, Lei Wei, Sasi Arunachalam, Kohei Hagiwara, Yanling Liu, Diane A. Flasch, Yu Liu, Matthew Parker, Xiaolong Chen, Abdelrahman H. Elsayed, Omkar Pathak, Yongjin Li, Yiping Fan, J. Robert Michael, Michael Rusch, Mark R. Wilkinson, Scott Foy, Dale J. Hedges, Scott Newman, Xin Zhou, Jian Wang, Colleen Reilly, Edgar Sioson, Stephen V. Rice, Victor Pastor Loyola, Gang Wu, Evadnie Rampersaud, Shalini C. Reshmi, Julie Gastier-Foster, Jaime M. Guidry Auvil, Patee Gesuwan, Malcolm A. Smith, Naomi Winick, Andrew J. Carroll, Nyla A. Heerema, Richard C. Harvey, Cheryl L. Willman, Eric Larsen, Elizabeth A. Raetz, Michael J. Borowitz, Brent L. Wood, William L. Carroll, Patrick A. Zweidler-McKay, Karen R. Rabin, Leonard A. Mattano, Kelly W. Maloney, Stuart S. Winter, Michael J. Burke, Wanda Salzer, Kimberly P. Dunsmore, Anne L. Angiolillo, Kristine R. Crews, James R. Downing, Sima Jeha, Ching-Hon Pui, William E. Evans, Jun J. Yang, Mary V. Relling, Daniela S. Gerhard, Mignon L. Loh, Stephen P. Hunger, Jinghui Zhang, Charles G. Mullighan

Publikováno v: Nat Genet

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL, we find that, despite a generally low mutation burden, ALL cases harbor a media

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da28edb235a257ae47b26e5df446208d
https://pubmed.ncbi.nlm.nih.gov/36050548

Excellent Outcomes With Reduced Frequency of Vincristine and Dexamethasone Pulses in Standard-Risk B-Lymphoblastic Leukemia: Results From Children's Oncology Group AALL0932

Autor: Mignon L. Loh, Johann K. Hitzler, Naomi J. Winick, Reuven J. Schore, Andrew J. Carroll, Ashley R. Lane, Brent L. Wood, Patrick A. Zweidler-McKay, Anne L. Angiolillo, Elizabeth A. Raetz, Nyla A. Heerema, Cindy Wang, Karen R. Rabin, Michael J. Borowitz, John A. Kairalla, Mary V. Relling, Meenakshi Devidas, William L. Carroll, Mylene Bassal, Kelly W. Maloney, Stephen P. Hunger

Publikováno v: J Clin Oncol

Purpose: AALL0932 evaluated two randomized maintenance interventions to optimize disease-free survival (DFS) while reducing the burden of therapy in children with newly diagnosed NCI standard-risk (SR) B-acute lymphoblastic leukemia (B-ALL). Methods:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::322001c7ded19d32e488655d4b478db4
https://pubmed.ncbi.nlm.nih.gov/33411585

Intravenous Anakinra for Treatment of Icans/HLH-like Complications of Tisagenlecleucel

Autor: Evelio Perez-Albuerne, Elizabeth Wells, Birte Wistinghausen, Anant Vatsayan, Anne L. Angiolillo, Erica Wyche, Shelby Smith, David A. Jacobsohn, Reuven J. Schore, Mellisa Wills, Hema Dave, Radha Rohatgi

Publikováno v: Transplantation and Cellular Therapy. 27:S206-S207

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c489c21d970820cca509be41d18bb1f
https://doi.org/10.1016/s2666-6367(21)00253-0