Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Anne L'Hernault"'
Autor:
Manivel Lodha, Ihsan Muchsin, Christopher Jürges, Vanda Juranic Lisnic, Anne L'Hernault, Andrzej J Rutkowski, Bhupesh K Prusty, Arnhild Grothey, Andrea Milic, Thomas Hennig, Stipan Jonjic, Caroline C Friedel, Florian Erhard, Lars Dölken
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1010992 (2023)
The genomes of both human cytomegalovirus (HCMV) and murine cytomegalovirus (MCMV) were first sequenced over 20 years ago. Similar to HCMV, the MCMV genome had initially been proposed to harbor ≈170 open reading frames (ORFs). More recently, omics
Externí odkaz:
https://doaj.org/article/ea5dbdd681fa4ad6a528c084c981f79a
Autor:
Adam W. Whisnant, Christopher S. Jürges, Thomas Hennig, Emanuel Wyler, Bhupesh Prusty, Andrzej J. Rutkowski, Anne L’hernault, Lara Djakovic, Margarete Göbel, Kristina Döring, Jennifer Menegatti, Robin Antrobus, Nicholas J. Matheson, Florian W. H. Künzig, Guido Mastrobuoni, Chris Bielow, Stefan Kempa, Chunguang Liang, Thomas Dandekar, Ralf Zimmer, Markus Landthaler, Friedrich Grässer, Paul J. Lehner, Caroline C. Friedel, Florian Erhard, Lars Dölken
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Here, using computational integration of multi-omics data, the authors provide a detailed transcriptome and translatome of herpes simplex virus 1 (HSV-1), including previously unidentified ORFs and N-terminal extensions. The study also provides a HSV
Externí odkaz:
https://doaj.org/article/2bc69e036d254f1f89647997e0dbd0b2
Autor:
Weimin Li, Ross Stewart, Thomas Powles, Joaquim Bellmunt, Feng Xiao, Ashok Gupta, Jill Walker, Melissa de los Reyes, Matthew Galsky, Sophie Wildsmith, Anne L’Hernault, Hannah Bye, Philip He, Qu Zhang, Rajiv Raja, Wendy Levin, Alexandra Drakaki, Michiel van der Heijden
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/bfecfa2ec4564ebcbea8a373a6c1ea02
Autor:
Thomas Hennig, Marco Michalski, Andrzej J Rutkowski, Lara Djakovic, Adam W Whisnant, Marie-Sophie Friedl, Bhaskar Anand Jha, Marisa A P Baptista, Anne L'Hernault, Florian Erhard, Lars Dölken, Caroline C Friedel
Publikováno v:
PLoS Pathogens, Vol 14, Iss 3, p e1006954 (2018)
Lytic herpes simplex virus 1 (HSV-1) infection triggers disruption of transcription termination (DoTT) of most cellular genes, resulting in extensive intergenic transcription. Similarly, cellular stress responses lead to gene-specific transcription d
Externí odkaz:
https://doaj.org/article/0b734ce74d4b448b8f8c6a89158cb1cf
Autor:
Stefanie Herb, Jelena Zeleznjak, Thomas Hennig, Anne L'Hernault, Manivel Lodha, Christopher Jürges, Tihana Trsan, Vanda Juranic Lisnic, Stipan Jonjic, Florian Erhard, Astrid Krmpotic, Lars Dölken
Publikováno v:
Journal of General Virology
Volume 103
Issue 11
Volume 103
Issue 11
Human cytomegalovirus is responsible for morbidity and mortality in immune compromised patients and is the leading viral cause of congenital infection. Virus-encoded microRNAs (miRNAs) represent interesting targets for novel antiviral agents. While m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e545e1e2462c1cc37092587b08ab857
https://doi.org/10.1099/jgv.0.001804
https://doi.org/10.1099/jgv.0.001804
Autor:
Solange Peters, Hisani Madison, Kelly Oliner, Anne L’Hernault, Marianne Ratcliffe, Karen Barrett, Xiaojin Shi, Edward B. Garon, Tony Mok, Melissa L. Johnson
Publikováno v:
Cancer Research. 83:CT080-CT080
Background: In the Phase 3 POSEIDON study (NCT03164616), 1L T plus D and platinum-based CT demonstrated statistically significant improvements in both PFS (HR, 0.72; 95% CI, 0.60-0.86; p=0.0003; data cutoff [DCO] July 24, 2019) and OS (HR, 0.77; 95%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11b90c2c498607349aac5017887a4ac1
https://doi.org/10.1158/1538-7445.am2023-ct080
https://doi.org/10.1158/1538-7445.am2023-ct080
Autor:
Thomas Powles, Qu Zhang, Weimin Li, Feng Xiao, Matthew D. Galsky, Jill Walker, Anne L’Hernault, Alexandra Drakaki, Michiel S. van der Heijden, Wendy Levin, Ross Stewart, Sophie Wildsmith, Melissa de los Reyes, Ashok K. Gupta, Joaquim Bellmunt, Hannah Bye, Rajiv Raja, Philip He
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background The phase III DANUBE study assessed the efficacy of the PD-L1 inhibitor durvalumab (D), alone or in combination with the CTLA-4 inhibitor tremelimumab (T), versus standard of care chemotherapy (SoC) for the first-line treatment of unresect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f94b7e15ef9840082710723cb95d13
https://doaj.org/article/bfecfa2ec4564ebcbea8a373a6c1ea02
https://doaj.org/article/bfecfa2ec4564ebcbea8a373a6c1ea02
Autor:
Mathilde Cancel, Toni K. Choueiri, Zsolt Szijgyarto, Sabina Signoretti, Jae-Lyun Lee, Remy B. Verheijen, Laurence Albiges, Anders Mellemgaard, Anne L’Hernault, Melanie M. Frigault, Daniel Y.C. Heng, Lone Ottesen
Publikováno v:
JAMA oncology. 6(8)
Importance Papillary renal cell carcinoma (PRCC) is the most common type of non-clear cell RCC. Because some cases of PRCC are MET-driven, MET inhibition could be a targeted treatment approach. In previous studies, savolitinib (AZD6094, HMPL-504, vol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87dcc43ce8336a219e6fc86f1d8d0957
https://pubmed.ncbi.nlm.nih.gov/32653414
https://pubmed.ncbi.nlm.nih.gov/32653414
Autor:
Anne L’Hernault, Vanda Juranić Lisnić, Marina Babić, Alec J. Redwood, Berislav Lisnić, Jelena Železnjak, Stipan Jonjić, Astrid Krmpotić, Silvia M. Vidal, Branka Popović, Florian Erhard, Hartmut Hengel, Tihana Lenac Rovis, Anne Halenius, Lars Dölken
Publikováno v:
The Journal of Experimental Medicine
Volume 216
Issue 8
Volume 216
Issue 8
Železnjak et al. demonstrate that two MCMV-encoded proteins interact with MHC I molecules, forming an altered-self complex that prevents missing self recognition by increasing specificity for inhibitory Ly49 receptors. This led to the evolution of C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5cac9e0e7c4bf3e0dde5a6772623257
https://urn.nsk.hr/urn:nbn:hr:184:650034
https://urn.nsk.hr/urn:nbn:hr:184:650034
Autor:
Florian W. H. Künzig, Thomas Hennig, Markus Landthaler, Paul J. Lehner, Stefan Kempa, Chunguang Liang, Caroline C. Friedel, Christopher S. Jürges, Thomas Dandekar, Florian Erhard, Margarete Göbel, Robin Antrobus, Adam W. Whisnant, Emanuel Wyler, Kristina Döring, Lars Dölken, Chris Bielow, Bhupesh K. Prusty, Anne L’Hernault, Ralf Zimmer, Nicholas J Matheson, Friedrich A. Grässer, Jennifer Menegatti, Guido Mastrobuoni, Andrzej J. Rutkowski
SummarySince the genome of herpes simplex virus 1 (HSV-1) was first sequenced more than 30 years ago, its predicted 80 genes have been intensively studied. Here, we unravel the complete viral transcriptome and translatome during lytic infection with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f611cb225490ef6d491008256de7d4f5
https://doi.org/10.1101/603654
https://doi.org/10.1101/603654