Elevated miR-615-3p Expression Predicts Adverse Clinical Outcome and Promotes Proliferation and Migration of Prostate Cancer Cells

Autor: Karina Dalsgaard Sørensen, Michael Borre, Jacob Fredsøe, Hein Vincent Stroomberg, Gitte Kristensen, Helle Kristensen, Linnéa Schmidt, Martin Andreas Røder, Klaus Brasso, Anne K.I. Rasmussen, Tina Fuglsang Daugaard, Siri H. Strand, Emma B. Laursen, Søren Høyer, Peter Mouritzen

Publikováno v: Laursen, E B, Fredsøe, J, Schmidt, L, Strand, S, Kristensen, H, Ildor Rasmussen, A K, Daugaard, T F, Mouritzen, P, Høyer, S, Kristensen, G, Stroomberg, H V, Brasso, K, Røder, M A, Borre, M & Sørensen, K D 2019, ' Elevated miR-615-3p Expression Predicts Adverse Clinical Outcome and Promotes Proliferation and Migration of Prostate Cancer Cells ', The American Journal of Pathology, vol. 189, no. 12, pp. 2377-2388 . https://doi.org/10.1016/j.ajpath.2019.08.007
Laursen, E B, Fredsøe, J, Schmidt, L, Strand, S H, Kristensen, H, Rasmussen, A K I, Daugaard, T F, Mouritzen, P, Høyer, S, Kristensen, G, Stroomberg, H V, Brasso, K, Røder, M A, Borre, M & Sørensen, K D 2019, ' Elevated miR-615-3p Expression Predicts Adverse Clinical Outcome and Promotes Proliferation and Migration of Prostate Cancer Cells ', The American Journal of Pathology, vol. 189, no. 12, pp. 2377-2388 . https://doi.org/10.1016/j.ajpath.2019.08.007

miR-615-3p has previously been described as up-regulated in prostate cancer (PC) tissue samples compared with nonmalignant controls; however, its prognostic potential and functional role in PC remain largely unknown. In this study, we investigated th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75aa93fa4597a2c0838afc4de5b64f2a
https://doi.org/10.1016/j.ajpath.2019.08.007

Diagnostic and Prognostic MicroRNA Biomarkers for Prostate Cancer in Cell-free Urine

Autor: Søren Høyer, Anne K.I. Rasmussen, Karina Dalsgaard Sørensen, Peter Mouritzen, Anni R. Thomsen, Michael Borre, Jacob Fredsøe, Torben F. Ørntoft

Publikováno v: Fredsøe, J, Rasmussen, A K I, Thomsen, A R, Mouritzen, P, Høyer, S, Borre, M, Ørntoft, T F & Sørensen, K D 2018, ' Diagnostic and Prognostic MicroRNA Biomarkers for Prostate Cancer in Cell-free Urine ', European Urology Focus, vol. 4, no. 6, pp. 825-833 . https://doi.org/10.1016/j.euf.2017.02.018

BACKGROUND: Widespread use of prostate-specific antigen (PSA) testing for prostate cancer (PC) detection has led to extensive overdiagnosis and overtreatment. Urine-based microRNA (miRNA) biomarkers could be useful in PC diagnosis and prognosis.OBJEC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e588c867c76a34fc39c7409316725b
https://doi.org/10.1016/j.euf.2017.02.018

A novel combined miRNA and methylation marker panel (miMe) for prediction of prostate cancer outcome after radical prostatectomy

Autor: Søren Besenbacher, Karina Dalsgaard Sørensen, Torben F. Ørntoft, Anne K.I. Rasmussen, Michael Borre, Siri H. Strand, Helle Kristensen, Elham Bavafaye‐Haghighi, Søren Høyer, Peter Mouritzen

Publikováno v: Strand, S H, Bavafaye-Haghighi, E, Kristensen, H, Rasmussen, A K, Hoyer, S, Borre, M, Mouritzen, P, Besenbacher, S, Orntoft, T F & Sorensen, K D 2019, ' A novel combined miRNA and methylation marker panel (miMe) for prediction of prostate cancer outcome after radical prostatectomy ', International Journal of Cancer, vol. 145, no. 12, pp. 3445-3452 . https://doi.org/10.1002/ijc.32427

Improved prognostic biomarkers are needed to guide personalized prostate cancer (PC) treatment decisions. Due to the prominent molecular heterogeneity of PC, multimarker panels may be more robust. Here, 25 selected top-candidate miRNA and methylation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754668211d857071505f27c64e6174b4
https://pubmed.ncbi.nlm.nih.gov/31125115