Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Anne K. Woodbrey"'
Autor:
Justin T. Cruite, Gabriela Kovacikova, Kenzie A. Clark, Anne K. Woodbrey, Karen Skorupski, F. Jon Kull
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-9 (2019)
The AraC/XylS-family transcriptional regulator ToxT is the master virulence activator of Vibrio cholerae, the gram-negative bacterial pathogen that causes the diarrheal disease cholera. Unsaturated fatty acids (UFAs) found in bile inhibit the activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb91d484d416a3132dc8fb3429d63fc
https://doi.org/10.1038/s42003-019-0686-x
https://doi.org/10.1038/s42003-019-0686-x
Autor:
Justin T, Cruite, Gabriela, Kovacikova, Kenzie A, Clark, Anne K, Woodbrey, Karen, Skorupski, F Jon, Kull
Publikováno v:
Communications Biology
The AraC/XylS-family transcriptional regulator ToxT is the master virulence activator of Vibrio cholerae, the gram-negative bacterial pathogen that causes the diarrheal disease cholera. Unsaturated fatty acids (UFAs) found in bile inhibit the activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4e37ef1287755d4b677e871688a25f64
https://pubmed.ncbi.nlm.nih.gov/31815195
https://pubmed.ncbi.nlm.nih.gov/31815195
We have previously designed and synthesized small-molecule inhibitors that reduce Vibrio cholerae virulence in vitro by targeting the transcription factor ToxT. Here we report the synthesis and biological activity of derivatives of our previous bicyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e2e77766bf09a2727b4969e8a67069
https://europepmc.org/articles/PMC6528795/
https://europepmc.org/articles/PMC6528795/
Autor:
Evans O. Onyango, Ronald K. Taylor, Gabriela Kovacikova, Anne K Woodbrey, F. Jon Kull, Maria Pellegrini, Gordon W. Gribble
Publikováno v:
Scientific Reports
Vibrio cholerae is responsible for the diarrheal disease cholera that infects millions of people worldwide. While vaccines protecting against cholera exist, and oral rehydration therapy is an effective treatment method, the disease will remain a glob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4e3f974d9d3d99ddc8c338f14042f7
https://doi.org/10.1038/srep45011
https://doi.org/10.1038/srep45011