Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Anne K. Voss"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
ING5 is a component of KAT6A and KAT7 histone lysine acetylation protein complexes. ING5 contains a PHD domain that binds to histone H3 lysine 4 when it is trimethylated, and so functions as a ‘reader’ and adaptor protein. KAT6A and KAT7 function
Externí odkaz:
https://doaj.org/article/5a0cf9e247bf49bda0abacad352fff70
Autor:
Johannes Wichmann, Catherine Pitt, Samantha Eccles, Alexandra L. Garnham, Connie S. N. Li-Wai-Suen, Rose May, Elizabeth Allan, Stephen Wilcox, Marco J. Herold, Gordon K. Smyth, Brendon J. Monahan, Tim Thomas, Anne K. Voss
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-13 (2022)
Abstract Histone acetylation is essential for initiating and maintaining a permissive chromatin conformation and gene transcription. Dysregulation of histone acetylation can contribute to tumorigenesis and metastasis. Using inducible cre-recombinase
Externí odkaz:
https://doaj.org/article/fa05505e61364d55b26a94489dc63e8d
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-6 (2022)
Programmed cell death, in particular the intrinsic apoptotic pathway, has been shown to play a critical role in the shaping of tissues during embryonic development. The multi-BCL-2 Homology (BH) domain effectors of apoptosis, BAX, BAK, and BOK, are e
Externí odkaz:
https://doaj.org/article/fac68ffed72f4a9c8e2a9daa6dcfa08a
Autor:
Andrew J. Kueh, Maria I. Bergamasco, Anna Quaglieri, Belinda Phipson, Connie S.N. Li-Wai-Suen, Ingrid M. Lönnstedt, Yifang Hu, Zhi-Ping Feng, Chris Woodruff, Rose E. May, Stephen Wilcox, Alexandra L. Garnham, Michael P. Snyder, Gordon K. Smyth, Terence P. Speed, Tim Thomas, Anne K. Voss
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111980- (2023)
Summary: In the conventional model of transcriptional activation, transcription factors bind to response elements and recruit co-factors, including histone acetyltransferases. Contrary to this model, we show that the histone acetyltransferase KAT7 (H
Externí odkaz:
https://doaj.org/article/4b0b1023c1f947b38cbb26ac1b1ba97c
Autor:
Brianna J. Klein, Suk Min Jang, Catherine Lachance, Wenyi Mi, Jie Lyu, Shun Sakuraba, Krzysztof Krajewski, Wesley W. Wang, Simone Sidoli, Jiuyang Liu, Yi Zhang, Xiaolu Wang, Becka M. Warfield, Andrew J. Kueh, Anne K. Voss, Tim Thomas, Benjamin A. Garcia, Wenshe R. Liu, Brian D. Strahl, Hidetoshi Kono, Wei Li, Xiaobing Shi, Jacques Côté, Tatiana G. Kutateladze
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Acetylation of histone H3K23 has emerged as an essential posttranslational modification, yet this epigenetic mark remains poorly understood. Here, the authors identify the native MORF complex as a histone H3K23-specific acetyltransferase and show tha
Externí odkaz:
https://doaj.org/article/78758c527c604e018605e9ed73ff1cd5
Autor:
Linhua Gan, Jingjing Sun, Shuo Yang, Xiaocui Zhang, Wu Chen, Yiyu Sun, Xiaohua Wu, Cheng Cheng, Jing Yuan, Anan Li, Mark A. Corbett, Mathew P. Dixon, Tim Thomas, Anne K. Voss, Jozef Gécz, Guang-Zhong Wang, Azad Bonni, Qian Li, Ju Huang
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3717-3728.e6 (2020)
Summary: Understanding the mechanisms of activity-dependent gene transcription underlying adaptive behaviors is challenging at neuronal-subtype resolution. Using cell-type specific molecular analysis in agouti-related peptide (AgRP) neurons, we revea
Externí odkaz:
https://doaj.org/article/d7c2fa9ecf73464dbbbdbbc44e5eea55
Autor:
Anne K. Voss, Andreas Strasser
Publikováno v:
F1000Research, Vol 9 (2020)
Apoptotic cells are commonly observed in a broad range of tissues during mammalian embryonic and fetal development. Specific requirements and functions of programmed cell death were inferred from early observations. These inferences did not hold up t
Externí odkaz:
https://doaj.org/article/6193ebf1a484406caa0ac85d867823fd
Autor:
Alex R.D. Delbridge, Andrew J. Kueh, Francine Ke, Natasha M. Zamudio, Farrah El-Saafin, Natasha Jansz, Gao-Yuan Wang, Megan Iminitoff, Tamara Beck, Sue Haupt, Yifang Hu, Rose E. May, Lachlan Whitehead, Lin Tai, William Chiang, Marco J. Herold, Ygal Haupt, Gordon K. Smyth, Tim Thomas, Marnie E. Blewitt, Andreas Strasser, Anne K. Voss
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 442-454.e5 (2019)
Summary: Neural tube defects (NTDs) are common birth defects in humans and show an unexplained female bias. Female mice lacking the tumor suppressor p53 display NTDs with incomplete penetrance. We found that the combined loss of pro-apoptotic BIM and
Externí odkaz:
https://doaj.org/article/09ca82a5c071461f8a7c7c4007a851a9
Autor:
Dane M. Newman, Shinya Sakaguchi, Aaron Lun, Simon Preston, Marc Pellegrini, Kseniya Khamina, Andreas Bergthaler, Stephen L. Nutt, Gordon K. Smyth, Anne K. Voss, Tim Thomas, Wilfried Ellmeier, Gabrielle T. Belz, Rhys S. Allan
Publikováno v:
Cell Reports, Vol 16, Iss 12, Pp 3311-3321 (2016)
How functionally diverse populations of pathogen-specific killer T cells are generated during an immune response remains unclear. Here, we propose that fine-tuning of CD8αβ co-receptor levels via histone acetylation plays a role in lineage fate. We
Externí odkaz:
https://doaj.org/article/c3c57588973b4e739d9d3cceeb66394a
Autor:
Stephanie Grabow, Andrew J. Kueh, Francine Ke, Hannah K. Vanyai, Bilal N. Sheikh, Michael A. Dengler, William Chiang, Samantha Eccles, Ian M. Smyth, Lynelle K. Jones, Frederic J. de Sauvage, Mark Scott, Lachlan Whitehead, Anne K. Voss, Andreas Strasser
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3285-3295.e4 (2018)
Summary: Apoptotic cell death removes unwanted cells and is regulated by interactions between pro-survival and pro-apoptotic members of the BCL-2 protein family. The regulation of apoptosis is thought to be crucial for normal embryonic development. A
Externí odkaz:
https://doaj.org/article/b958c8def9dc4e4eb7387f18421e59a4